We investigated injury-induced heat shock protein 27 (HSP27) expression and its association to axonal outgrowth after injury and different nerve repair models in healthy Wistar and diabetic Goto-Kakizaki rats. By immunohistochemistry, expression of HSP27 in sciatic nerves and DRG and axonal outgrowth (neurofilaments) in sciatic nerves were analyzed after no, immediate, and delayed (7-day delay) ne

Cisplatin is one of the most commonly used drugs for the treatment of various solid cancers. However, its efficacy is restricted by severe side effects, especially dose-limiting nephrotoxicity. New platinum-based compounds are designed to overcome this limitation. Previous investigations showed that the platinum(IV)–nitroxyl complex PN149 is highly cytotoxic in various tumor cell lines. In the pre

Chapter about the reactions to and reception of the arrival of refugees in Octover and November 1943 and during the spring of 1945 in the south of Sweden.

ScopeAccurate numerical modeling of fluid transport is essential in reservoir management. Higher-order methods help to improve accuracy by reducing the numerical diffusion, which is common for all first order methods. In this paper, we present an implementation of a MUSCL-type second-order finite volume method and demonstrate its capabilities on 2D and 3D unstructured grids. This includes corner p

This Data in Brief article describes data on the movement behaviour of four species of grassland butterflies collected over three years and at four sites in southern England. The datasets consist of the movement tracks of Maniola jurtina, Aricia agestis, Pyronia tithonus, and Melanargia galathea, recorded using standard methods and presented as steps distances and turning angles. Sites consisted o

BACKGROUND: Per- and polyfluoroalkyl substances (PFAS) exposure has been linked to metabolic health outcomes such as obesity, and changes in adipokine hormones may be one of the underlying biological mechanisms. We prospectively evaluated the associations between prenatal and early childhood exposures to PFASs and adipokines in children.MATERIAL AND METHODS: PFAS concentrations were measured in se

Numerous studies have reported a positive association between ambient fine particles and daily mortality, but little is known about the particle properties or environmental factors that may contribute to these effects. This study assessed potential modification of radon on PM2.5 (particulate matter with an aerodynamic diameter

BACKGROUND: Improvements in surgery, imaging, adjuvant treatment, and management of metastatic disease have led to modification of previous approaches regarding the risk of recurrence and prognosis in colorectal cancer. The aims of this study were to map patterns, risk factors, and the possibility of curative treatment of recurrent colorectal cancer in a multimodal setting. METHODS: This was a coh

Background: Changes in grey matter covariance networks have been reported in preclinical and clinical stages of Alzheimer’s disease (AD) and have been associated with amyloid-β (Aβ) deposition and cognitive decline. However, the role of tau pathology on grey matter networks remains unclear. Based on previously reported associations between tau pathology, synaptic density and brain structural measu

We present a global atlas of 4,728 metagenomic samples from mass-transit systems in 60 cities over 3 years, representing the first systematic, worldwide catalog of the urban microbial ecosystem. This atlas provides an annotated, geospatial profile of microbial strains, functional characteristics, antimicrobial resistance (AMR) markers, and genetic elements, including 10,928 viruses, 1,302 bacteria

The 5G Edge Intelligence for Vertical Experimentation (5G-DIVE) project aims at demonstrating the technical merits and business value proposition of 5G technologies in two vertical pilots, namely the Industry 4.0 (I4.0) and Autonomous Drones Scout (ADS) pilots. This paper presents an overview of the overall 5G-DIVE solution and reports the results of the initial validation campaign of the selected