Exhaled breath temperature has been suggested to reflect airway inflammation, and it would be plausible to measure the peripheral airway temperature as a correlate to peripheral airway inflammation. This study aims to explore the relative peripheral airway temperature in patients with asthma, chronic obstructive pulmonary disease (COPD) or systemic sclerosis (SSc) compared to healthy controls, and

Background: A psychosocial dementia care programme for challenging behaviour (DEMBASE®) was developed in collaboration with a Swedish BPSD-registry team for in-home care services use in Japan. The programme consisted of a web-based tool for the continued assessment of challenging behaviours and interdisciplinary discussion meetings. Effectiveness of the adapted programme was verified through a clu

The article examines the relationship between third-party countermeasures and the Security Council's powers to adopt measures under Chapter vii of the United Nations Charter in response to breaches of obligations erga omnes. It is shown that the resort to third-party countermeasures is neither precluded nor subject to limitations as a result of the relationship to the Security Council's Chapter vi

Purpose: The study aimed to investigate expression of epithelial-to-mesenchymal transition (EMT)-related proteins and phenotypes during breast cancer progression and to relate this to patient outcome. Methods: Protein expression patterns of E-cadherin, N-cadherin, twist, and vimentin were examined by immunohistochemistry on formalin-fixed paraffin-embedded samples from primary tumors (PTs) (n = 41

Large-Eddy Simulations (LES) based on scale-selective implicit filtering are carried out in order to study the effect of nozzle pressure ratios on the characteristics of highly underexpanded jets. Pressure ratios ranging from 3 to 9 with Reynolds numbers of the order 70000 to 150000 are considered. The studied configuration agrees well with the classical picture of the structure of highly underexp

Background: Pediatric asthma remains a public health challenge with enormous impact worldwide. Objective: The aim of this study was to identify and prioritize unmet clinical needs in pediatric asthma, which could be used to guide future research and policy activities. Methods: We first identified unmet needs through an open-question survey administered to international experts in pediatric asthma

A channel sounder is an advanced measurement system to estimate the behavior of wireless propagation channels. In this paper, we present the antenna array design for a 28GHz massive multiple-input multiple-output system, capable of measuring 256×128 dual-polarized channels, including dynamic properties of angular, delay, Doppler, and polarization parameters, respectively. Unique in comparison to o

Previously, intragenic CAMTA1 copy number variants (CNVs) have been shown to cause non-progressive, congenital ataxia with or without intellectual disability (OMIM#614756). However, ataxia, intellectual disability, and dysmorphic features were all incompletely penetrant, even within families. Here, we describe four patients with de novo nonsense, frameshift or missense CAMTA1 variants. All four pa

Objective Atrial fibrillation (AF) is the most common arrhythmia and associated with increased morbidity and mortality. Its increasing prevalence calls for novel biomarkers to identify underlying pathophysiological mechanisms as well as patients at risk. Methods Plasma samples from 1694 individuals from the Swedish population-based Malmö Preventive Project (mean age 69.5 years; 29.3% female; mean

The western Antarctic Peninsula is an extreme low temperature environment that is warming rapidly due to global change. Little is known, however, on the temperature sensitivity of growth of microbial communities in Antarctic soils and in the surrounding oceanic waters. This is the first study that directly compares temperature adaptation of adjacent marine and terrestrial bacteria in a polar envir

Several lines of evidence point to an increase in the activity of the terrestrial biosphere over recent decades, impacting the global net land carbon sink (NLS) and its control on the growth of atmospheric carbon dioxide (ca). Global terrestrial gross primary production (GPP)—the rate of carbon fixation by photosynthesis—is estimated to have risen by (31 ± 5)% since 1900, but the relative contribu

Parkinsons sjukdom är den näst vanligaste neurodegenerativa sjukdomen. Lewykroppar med alfa-synuklein som huvudbeståndsdel och förlust av dopaminerga nervceller i substantia nigra är neuropatologiska kännetecken. Diagnosen baseras på förekomst av bradykinesi och rigiditet eller vilotremor. Sjukdomen är också förknippadmed många icke-motoriska symtom. Behandlingen baserar sig främst på farmakologisParkinson's disease is the second most common neurodegenerative disease. Lewy bodies with alpha-synuclein as the major component and loss of dopaminergic nerve cells in substantia nigra are neuropathological features. The diagnosis of Parkinson's disease is based on the occurrence of bradykinesia, rigidity and resting tremor. The disease is also associated with several non-motor symptoms. The ther

In scrutinizing a scene, the eyes alternate between fixations and saccades. During a fixation, two component processes can be distinguished: visual encoding and selection of the next fixation target. We aimed to distinguish the neural correlates of these processes in the electrical brain activity prior to a saccade onset. Participants viewed color photographs of natural scenes, in preparation for

In the next 24 years, the Malawian population is expected to double, a development that will inevitably affect access to land and land holding sizes. As access to land is already limited, securing food for the growing population will require policy shifts including the promotion of agricultural intensification. Malawi’s economy depends on the agricultural sector, and this paper addresses the gener

This article reports a Swedish research project designed to study the impact of a cyclic light system, sound absorbents, and selected interior design changes in rooms within an intensive care unit. The authors describe the limitations of many previously reported intensive care unit (ICU) design research projects, and believe that much more knowledge is needed, which reflects a multidisciplinary pe

The BGOOD experiment at the ELSA facility in Bonn has been commissioned within the framework of an international collaboration. The experiment pursues a systematic investigation of non-strange and strange meson photoproduction, in particular t-channel processes at low momentum transfer. The setup uniquely combines a central almost 4 π acceptance BGO crystal calorimeter with a large aperture forwar

BACKGROUND: Postural orthostatic tachycardia syndrome (POTS) is a variant of cardiovascular (CV) autonomic disorder of unknown etiology characterized by an excessive heart rate increase on standing and orthostatic intolerance. In this study we sought to identify novel CV biomarkers potentially implicated in POTS pathophysiology.METHODS: We conducted a nested case-control study within the Syncope S

Gel formation by surfactant molecules is generally controlled by thermodynamics rather than kinetics. Mixtures of long-chain alcohols and surfactants are widely used in various cosmetic and pharmaceutical products. The cooling rate used to produce the products is known to be a key parameter to control the rheological properties and the final texture. However, the physical-chemistry links between t

AbstractThe building sector in Sweden and Europe is a major energy consumer, accounting for around 40% of total energy use. It is a challenge to optimize available technical and social strategies for the fragmented construction industry. Professionals such as architects and different building engineers play a crucial role in the technology adoption process.This study aims to contribute to the unde