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Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed-lineage kinase pathway
Models of Parkinson's disease (PD) based on selective neuronal death have been used to study pathogenic mechanisms underlying nigral cell death and in some instances to develop symptomatic therapies. For validation of putative neuroprotectants, a model is desirable in which the events leading to neurodegeneration replicate those occurring in the disease. We developed a human in vitro model of PD b
Varför är svensk popmusik så populär utomlands? Synpunkter på det ”svenska musikundret” och på det spontana i popmusikens musikaliska språk
This paper discusses the reasons for the recent success of Swedish popular music abroad. It departs from recent Swedish economic reports showing that the increase in exports of Swedish music per capita is comparable to, and even exceeds, those of the United Kingdom and the United States, and presents theories about why Swedish popular music exports have grown during the last years. A method of mu
Platination of the siRNA sense-strand modulates both efficacy and selectivity in vitro
The use of short interfering RNAs (siRNA) for selective suppression of protein production has rapidly become a commonly used technique for transient modulation of protein levels. In the present paper, we investigate whether introduction of platinated bases in the sense strand can be used to modulate the efficacy of siRNAs. Four different siRNAs were studied, all targeting the initial AU-rich 3' UT
TAS-20 alexithymia in obesity, and its links to personality
We studied the association between alexithymia (20-item Toronto Alexithymia Scale, TAS-20) and obesity, and also assessed the construct validity of the TAS-20 in terms of personality dimensions in obese patients. The TAS-20 and its subscales were analysed for their correlations with the NEO Personality Inventory - Revised (NEO PI-R) in an obese sample of 259 patients. Obesity was associated with h
Kinetics of the coupled reaction catalysed by a fusion protein of yeast mitochondrial malate dehydrogenase and citrate synthase: Kinetics of a fusion protein of MDH and CS
The mechanistic implications of the kinetic behaviour of a fusion protein of mitochondrial malate dehydrogenase and citrate synthase have been reanalysed in view of predictions based on experimentally determined kinetic parameter values for the dehydrogenase and synthase activities of the protein. The results show that the time-course of citrate formation from malate in the coupled reaction cataly
Sexual conflict over floral receptivity
In flowering plants, the onset and duration of female receptivity vary among species. In several species the receptive structures wilt upon pollination. Here we explore the hypothesis that postpollination wilting may be influenced by pollen and serve as a general means to secure paternity of the pollen donor at the expense of female fitness. Taking a game-theoretical approach, we examine the poten
Traffic-generated emissions of ultrafine particles from pavement-tire interface
In a road simulator study, a significant source of sub-micrometer fine particles produced by the road-tire interface was observed. Since the particle size distribution and source strength is dependent on the type of tire used, it is likely that these particles largely originate from the tires, and not the road pavement. The particles consisted most likely of mineral oils from the softening filler
Reliability of isokinetic ankle dorsiflexor strength measurements in healthy young men and women
The purposes of this study were: (i) to determine the test-retest reliability of isokinetic ankle dorsiflexor strength measurements in young healthy adults using the Biodex dynamometer, and (ii) to examine several statistical measures for the interpretation of reliability. Thirty men and women (mean age 23 +/- 3 years) performed three maximal concentric contractions at 30 degrees/s, 60 degrees/s,
Suicide Rates in the Lundby Cohort before and after the Introduction of Tricyclic Antidepressant Drugs.
Intracellular lipids and inflammatory activity in macrophage foam cells
Popular Abstract in Swedish Kardiovaskulär sjukdom karaktäriseras av lipid accumulering och inflammation i artärerna. Sjukdomen startar tidigt med att monocyter vandrar ut i kärlväggen där de differentierar till makrofager, tar upp modifierade lipoproteiner och utvecklas till skumceller. En samtidig inflammation bidrar till att fler celler och mer lipider ansamlas och ett aterosklerotiskt plack böCardiovascular disease (CVD) is characterized by lipid accumulation and inflammation in arteries. The disease starts early in life with migration of monocytes into the arterial wall where they engulf entrapped lipoproteins and become macrophage foam cell. A simultaneous inflammatory response further enhances lipid and cell accumulation at sites of lesion development, resulting in progression of at
Bryophytes on loess cliffs in Bulgaria – a preliminary study
alpha-Ketoglutarate in biological hydroxylations
The Lund concept: is this logical?
Microarray analysis of gliomas reveals chromosomal position-associated gene expression patterns and identifies potential immunotherapy targets.
Gliomas are among the most aggressive malignant tumors and the most refractory to therapy, in part due to the propensity for malignant cells to disseminate diffusely throughout the brain. Here, we have used 27 K cDNA microarrays to investigate global gene expression changes between normal brain and high-grade glioma (glioblastoma multiforme) to try and better understand gliomagenesis and to identi
Bostadsområdet som fetisch och faktisch - en metodologisk studie till frågan om den konkreta formens betydelser
Byggd miljö knyts med tiden ofta till olika mer eller mindre specifika betydelser. Vill vi förändra staden måste vi också förhålla oss till de livsmönster och det bruk som uppstått inom ramen för den gamla bebyggelsen, oavsett om vi vill bygga nytt vid sidan av eller förändra det gamla i grunden. Denna artikel avser belysa något kring hur vi kan undersöka en sådan lokal etablering av betydelser oc
Effects of short-term treatment with corticotropin on the serum apolipoprotein pattern
Treatment with adrenocorticotrophic hormone (ACTH) has a well-documented cholesterol-lowering effect. Increased uptake of low-density lipoprotein (LDL) by HepG2 cells in response to incubation with ACTH has been demonstrated but the precise cholesterol-lowering mechanism has resisted elucidation. Since apolipoproteins are important determinants of lipoprotein metabolism, we sought to extend the kn