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The calcium-dependent transcription factor NFAT was first described as a key player in immune cell regulation. Since then, NFAT signaling has been shown to be crucial for normal vascular development during embryogenesis. This pathway is also an important regulator of cell growth and differentiation in various cell types, however, the functional significance of NFAT in the vasculature is largely un
Recent numerical simulations have shown long-lived axisymmetric sub- and super-Keplerian flows in protoplanetary disks. These zonal flows are found in local as well as global simulations of disks unstable to the magnetorotational instability. This paper covers our study of the strength and lifetime of zonal flows and the resulting long-lived gas over- and underdensities as functions of the azimuth
Popular Abstract in Swedish Avhandlingen tar upp frågor om prästernas arbetsmiljö och deras roll och identitet. I inledningskapitlet framhölls att flera faktorer är viktiga för en undersökning om prästernas arbetsmiljö och för utformningen av prästrollen och prästidentiteten. Det omgivande samhället, de organisatoriska ramarna och de förväntningar som ställs på prästerna är några sådana faktorer, In this dissertation the work environment and the roles and identities of the clergy in the Church of Sweden are investigated. It is said in the first chapter that there are several factors influencing the work environment and that these factors are important for the formation of the roles and identities of the clergy. The surrounding society, the organization, and the expectations directed at the
Novel radiography approaches based on the wave nature of x-rays when propagating through matter have a great potential for improved future x-ray diagnostics in the clinics. Here, we present a significant milestone in this imaging method: in-vivo multi-contrast x-ray imaging of a mouse using a compact scanner. Of particular interest is the enhanced contrast in regions related to the respiratory sys
We have characterized the lipid chain freezing in dilute aqueous vesicle dispersions of the cationic lipid dioctadecyldimethylammonium bromide (DODAB) using wide and small angle X-ray scattering, solid state NMR, DSC, turbidity and density measurements. The lipids freeze in two steps. Above 40 degrees C the chains are fluid and the lipids are in a so-called liquid-crystalline state. When cooling b
Popular Abstract in Swedish Dödligheten i skador i Sverige har under de senaste årtiondena minskat, en minskning som idag dock har planat ut. Antalet dödade i transportolyckor och i arbetsplatsolyckor i Sverige har minskat under de senaste 40 åren vilket kan ses som ett resultat av ett effektivt säkerhetsarbete. När det gäller fallolyckor så har däremot andelen som dör av sina skador ökat markant Injuries are often associated with long-term suffering and lowered functioning, and personal injuries impose a huge burden on medical care and health services in addition to the costs associated with impaired functional ability. Each year in Sweden, falling accidents are experienced by a third of those aged 60 or over and half of those aged 80 or over, while injuries from traffic accidents still a
A search has been performed for the experimental signature of an isolated photon with high transverse momentum, at least one jet identified as originating from a bottom quark, and high missing transverse momentum. Such a final state may originate from supersymmetric models with gauge-mediated supersymmetry breaking in events in which one of a pair of higgsino-like neutralinos decays into a photon
A search is presented for a narrow resonance decaying to a pair of Z bosons using data corresponding to 1.02 fb(-1) of integrated luminosity collected by the ATLAS experiment from pp collisions at root s= 7 TeV. Events containing either four charged leptons (llll) or two charged leptons and two jets (lljj) are analyzed and found to be consistent with the Standard Model background expectation. Lowe
We report on the fabrication and characterisation of a gold-nanoparticle (AuNP)-based mediatorless sugar/oxygen biofuel cell (BFC) operating in neutral sugar-containing buffers and human physiological fluids, such as blood and plasma. First, Corynascus thermophilus cellobiose dehydrogenase (CtCDH) and Myrotheciumverrucaria bilirubin oxidase (MvBOx), used as anodic and cathodic bioelements, respect
The recently identified phylogenetic subgroup B5 of fungal glycoside hydrolase family 18 genes encodes enzymes with mannosyl glycoprotein endo-N-acetyl-b-D-glucosaminidase (ENGase)-type activity. Intracellular ENGase activity is associated with the endoplasmic reticulum associated protein degradation pathway (ERAD) of misfolded glycoproteins, although the biological relevance in filamentous fungi
A convenient one-pot preparation of [(BINAP) Re(O)Cl-3] (6) is described. This complex was demonstrated to be an efficient catalyst for the olefination of aldehydes by reaction with alpha-diazo esters, with essentially quantitative yields and up to 98:2 geometric selectivity. The potential for using enantiopure [(BINAP)Re(O)Cl-3] (6) to promote an asymmetric kinetic resolution of racemic alpha-ste
Liquid displacement of model and industrial fluids in pipes was successfully investigated using the in-line rheometer concept based on the combination of Ultrasound Doppler Velocity Profiling (UVP) and the pressure difference (PD) technique. The velocity profile development, related mixing zone and real-time changes in rheology were monitored when one fluid was displaced by another with different
Popular Abstract in Swedish Grundvatten, det vatten som förekommer i hålrum i underjorden, är en av våra allra viktigaste naturresurser. Grundvattnet utgör den absolut största andelen för oss tillgängligt färskvatten och används för att producera mat och som processvatten inom olika industrier. Ungefär hälften av jordens dricksvattenförsörjning baseras på grundvattenuttag och ekosystem världen övePesticides are known to occur in groundwater worldwide. However, long-term pollution concerns and cause-effect relationships for specific regions remain limited. This thesis explores the occurrence of pesticides in south-Swedish groundwater, with the aims of providing a better knowledge basis for assessment and management of present-day and future pollution risks. The investigations are restricted
Background: Left ventricular (LV) dysfunction is well documented in the critically ill. We assessed 1-year mortality in relation to cardiac biomarkers and LV function parameters by echocardiography in patients with shock. Methods: A prospective, observational, cohort study of 49 patients. B-natriuretic peptide (BNP), high-sensitive troponin T (hsTNT) and transthoracic echocardiography (TTE) were a
Entanglement evolution is studied in open systems represented by rings of qubits with the Ising interaction and variously oriented external field and with Markov environments. The effect of thermal or dephasing environment is manifested as exponential decrease of the entanglement superposed on its dynamics in the isolated system. (C) 2009 Elsevier B.V. All rights reserved.
Purpose: To investigate the effects of visual and tactile intra-oral sensor-position feedback for target selection tasks with the tip of the tongue. Method: Target selection tasks were performed using an inductive tongue-computer interface (ITCI). Visual feedback was established by highlighting the area on a visual display corresponding to the activated intra-oral target. Tactile feedback was esta
Although the elderly have a substantially higher drug use than younger patients, even after adjustment for multimorbidity, there is limited knowledge about the elderly's indication for treatment. It is essential for elderly patients to have a well-planned drug therapy. The first step towards a correct and safe drug therapy is to ensure that the patient's drugs have an indication, i.e. correct diag
The objective of this study was to assess the reciprocal association between non-Hodgkin lymphoma (NHL) and Merkel cell carcinoma (MCC) using the data of four Nordic Cancer Registries. Data for this study were drawn from the Danish, Finnish, Norwegian, and Swedish cancer registries. Standardized incidence ratios (SIRs) for MCC among NHL patients, and for NHL among MCC patients, were calculated. Th
