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Subsequent primary malignancies after endometrial carcinoma and ovarian carcinoma

BACKGROUND: Population-based data on subsequent neoplasms after women are diagnosed with endometrial and ovarian carcinomas are limited, particularly regarding specific histologic tumor types.METHODS: The nationwide Swedish Family-Cancer Database of 10.2 million individuals, which includes 19,128 invasive endometrial carcinomas and 19,440 ovarian carcinomas, was used to calculate standardized inci

Age-incidence relationships and time trends in cervical cancer in Sweden

Age-incidence relationships are informative of carcinogenic mechanisms. These have been previously assessed for cervical squamous cell carcinoma (SCC) but not for adenocarcinoma. The aim was to assess by means of age-, period- and cohort-specific analyses and Poisson regression modelling whether the two types of cervical cancer show an age-incidence maximum at a relatively young age, as shown in c

Gudme

Gudme [p. 693]; Himlingøje [p. 723]; Lundeborg [p. 926]; Skedemosse [p. 1393]; Vorbasse [p. 1574]; Uppåkra [p. 1541]

Identification of the two-component guaiacol demethylase system from Rhodococcus rhodochrous and expression in Pseudomonas putida EM42 for guaiacol assimilation

A diversity of softwood lignin depolymerization processes yield guaiacol as the main low molecular weight product. This key aromatic compound can be utilized as a carbon source by several microbial species, most of which are Gram positive bacteria. Microbial degradation of guaiacol is known to proceed initially via demethylation to catechol, and this reaction is catalyzed by cytochrome P450 monoox

Female Workers but not Women: Paradoxes in Women’s Conditions and Strategies in Swedish Trade Unions, 1900–1925

This article compares the opportunities that existed for trade union organisation by women and the scope for pursuing women’s issues in the Swedish Tailoring Workers’ Union (Skrädderiarbetareförbundet), the Swedish Textile Workers’ Union (Textilarbetareförbundet) and the Swedish Women’s Trade Union (Kvinnornas fackförbund). Trade union minutes are analysed using theories on women’s organisation, i

Survival in common cancers defined by risk and survival of family members

Studies on survival between familial and sporadic cancers have been inconclusive and only recent data on a limited number of cancers are available on the concordance of survival between family members. In this review, we address these questions by evaluating the published and unpublished data from the nation-wide Swedish Family-Cancer Database and a total of 13 cancer sites were assessed. Using sp

Mature neutrophils suppress T cell immunity in ovarian cancer microenvironment

Epithelial ovarian cancer (EOC) often presents with metastases and ascites. Granulocytic myeloid-derived suppressor cells are an immature population that impairs antitumor immunity. Since suppressive granulocytes in the ascites of patients with newly diagnosed EOC were morphologically mature, we hypothesized that PMN were rendered suppressive in the tumor microenvironment (TME). Circulating PMN fr

Impact of gender on echocardiographic characteristics in heart transplant recipients

Aims: Assessment following heart transplantation (HTx) is routinely performed using transthoracic echocardiography. Differences in long-term mortality following HTx related to donor-recipient matching have been reported, but effects of gender on cardiac size and function are not well studied. The aims of this study were to evaluate differences in echocardiographic characteristics of HTx recipients

TSC-associated neuropsychiatric disorders (TAND) : findings from the TOSCA natural history study

BACKGROUND: Most evidence for TSC-associated neuropsychiatric disorders (TAND) to date have come from small studies and case reports, and very little is known about TAND in adults. We explored baseline TAND data from the large-scale international TOSCA natural history study to compare childhood and adult patterns, describe age-based patterns, and explore genotype-TAND correlations.RESULTS: The stu

Antibiotic therapy in acute pancreatitis: From global overuse to evidence based recommendations

Background: Unwarranted administration of antibiotics in acute pancreatitis presents a global challenge. The clinical reasoning behind the misuse is poorly understood. Our aim was to investigate current clinical practices and develop recommendations that guide clinicians in prescribing antibiotic treatment in acute pancreatitis. Methods: Four methods were used. 1) Systematic data collection was pe

Revealing turning points in ecosystem functioning over the Northern Eurasian agricultural frontier

The collapse of the Soviet Union in 1991 has been a turning point in the World history that left a unique footprint on the Northern Eurasian ecosystems. Conducting large scale mapping of environmental change and separating between naturogenic and anthropogenic drivers is a difficult endeavor in such highly complex systems. In this research a piece-wise linear regression method was used for breakpo

The intrinsic charm of the proton

Recent data give unexpectedly large cross-sections for charmed particle production at high xF in hadron collisions. This may imply that the proton has a non-negligible uudcc Fock component. The interesting consequences of such a hypothesis are explored.

Incidence trends and risk factors of carcinoid tumors : a nationwide epidemiologic study from Sweden

BACKGROUND: Carcinoids are rare indolent neuroendocrine tumors, mainly located in bowel, stomach, and lung. Their etiology is virtually unknown although a family history is a minor cause.METHODS: Site specific incidence trends and several risk factors of carcinoid tumors were studied based on the nationwide Swedish Family-Cancer Database of 10.2 million individuals and their more than 1 million tu

Humanister lyfts ur glömskan

Recension av: Monica Lauritzen "Karl Warburg. Den varsamme vägvisaren" och Kjell Espmark "Martin Lamms ögonblick"