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In the body, all cell surfaces are covered with glycans, and many regulatory components havecarbohydrates attached to them, which can aid in their function. Galectins are a family of proteins whichcan bind to specific glycans and oligosaccharides and cross-link them to influence a wide range of cellularprocesses. The members of the galectin family are structurally similar and can be involved in th

Many concepts for future generations of wireless communication systems use coherent processing of signals from many distributed antennas. The aim is to improve communication reliability, capacity, and energy efficiency and provide possibilities for new applications through integrated communication and sensing. The large bandwidths available in the higher bands have inspired much work regarding sen

This paper introduces an improved method for real-time brain computer interface control. We demonstrate how Bayesian optimization and feedback can be used to achieve faster statistical convergence by controlling the sequence of stimuli shown in a brain computer interface based on a visual oddball paradigm.

Objectives: To assess whether extended surveillance with repeated computed tomography (CT) scans for patients with clinical stage IIA (CS IIA; <2 cm abdominal node involvement) and negative markers (Mk−) non-seminomatous germ cell tumours (NSGCTs) can identify those with true CS I. To assess the rate of benign lymph nodes, teratoma, and viable cancer in retroperitoneal lymph node dissection (RPLND

Changes in environmental temperature during development can affect growth, metabolism and temperature tolerance of the offspring. We know little about whether such changes remain to adulthood, which is important to understand the links between climate change, development and fitness. We investigated whether phenotypic consequences of the thermal environment in early life remained in adulthood in t

Gravity-driven filtration through slow sand filters (SSFs) is one of the oldest methods for producing drinking water. As water passes through a sand bed, undesired microorganisms and chemicals are removed by interactions with SSF biofilm and its resident microbes. Despite their importance, the processes through which these microbial communities form are largely unknown, as are the factors affectin

In this study, a comprehensive investigation of a set of phytochemicals to identify potential inhibitors for the Forkhead box protein M1 (FOXM1) was conducted. FOXM1 is overexpressed in glioblastoma (GBM) cells and plays a crucial role in cell cycle progression, proliferation, and invasion. FOXM1 inhibitors have shown promising results in preclinical studies, and ongoing clinical trials are assess

Extant literature points to how the risk of discrimination is intrinsic to AI systems owing to the dependence on training data and the difficulty of post hoc algorithmic auditing. Transparency and auditability limitations are problematic both for companies’ prevention efforts and for government oversight, both in terms of how artificial intelligence (AI) systems function and how large-scale digita

1. Two recent clinical trials, KetECT and ELEKT-D, compared the effectiveness of ketamine and electroconvulsive therapy (ECT) for major depressive disorder. Notably, these trials reported marked differences in ECT's clinical outcomes of, with remission rates of 63% for KetECT and a strikingly lower rate of 22% for ELEKT-D, while the remission rates for ketamine were 46% and 38%, respectively. Cons

We verify safety of a nonlinear continuous-time system controlled by a neural network controller. The system is decomposed into low-dimensional subsystems connected in a feedback loop. Our application is a rocket landing, and open-loop properties of the two-dimensional altitude subsystem are verified using worst-case simulations. Closed-loop safety properties (crash-avoidance) of the full system a

Introduction: Regenerative agriculture commonly aims to increase soil carbon sequestration, with potential benefits for human and ecosystem health, climate mitigation, and biodiversity. However, the effectiveness of various regenerative practices at increasing carbon sequestration is unclear. Methods: This study identified and quantified the yearly soil carbon sequestration rate of regenerative pr

Extraterrestrial chrome spinel and chromite extracted from the sedimentary rock record are relicts from coarse micrometeorites and rarely meteorites. They are studied to reconstruct the paleoflux of meteorites to the Earth and the collisional history of the asteroid belt. Minor element concentrations of Ti and V, and oxygen isotopic compositions of these relict minerals were used to classify the m

Hormone-sensitive lipase (HSL) is active throughout the brain and its genetic ablation impacts brain function. Its activity in the brain was proposed to regulate bioactive lipid availability, namely eicosanoids that are inflammatory mediators and regulate cerebral blood flow (CBF). We aimed at testing whether HSL deletion increases susceptibility to neuroinflammation and impaired brain perfusion u

X-ray phase-contrast imaging by grating interferometry has in the past decades been established both at synchrotron radiation sources and at conventional x-ray tubes. Due to the sensitivity to x-ray phase shifting, contrast in soft tissue has been improved significantly and the possibilities to do virtual histology of tissue biopsies are being pioneered. Constraints in the design of a grating inte

Aim: To evaluate the incidence of chromosomal aberrations in apparently isolated ventricular septal defects (VSD), quantify the timing of diagnosis of prenatally diagnosed VSDs, and define the spontaneous closure rate prenatally both in utero and during the first year of life. Materials and methods: Medline, PubMed, and the Cochrane Database Library were searched to identify studies published betw

Jorge Ibargüengoitia is one of the most prominent writers in 20th-century Mexican literature. This study provides an analysis of his narrative in the work Dos Crímenes. The primary objective is to elucidate how the author constructs his narrative threads through the use of irony, which becomes a recurrent tool in his style. To accomplish this, it is proposed that Ibargüengoitia employs different t

Critical constructive feedback (CCF), is said to be a key ingredient in learning. However, if and how learners engage in CCF is rarely studied in collaborative learning situations. This study aims to filling this research gap by analyzing data logs from dyads of middle school students using an educational game in history, evaluating their inclination to dismiss or attend to feedback when making er

Objective: Giant cell arteritis (GCA) is an age-related vasculitis. Prior studies have identified an association between GCA and hematologic malignancies (HMs). How the presence of somatic mutations that drive the development of HMs, or clonal hematopoiesis (CH), may influence clinical outcomes in GCA is not well understood. Methods: To examine an association between CH and GCA, we analyzed sequen