Background - Previous reports have implicated multiple genetic loci associated with AF, but the contributions of genome-wide variation to AF susceptibility have not been quantified. Methods and Results - We assessed the contribution of genome-wide single-nucleotide polymorphism variation to AF risk (single-nucleotide polymorphism heritability, h2 g) using data from 120 286 unrelated individuals of

Purpose: In 90Y microsphere radioembolization (RE), accurate post-therapy imaging-based dosimetry is important for establishing absorbed dose versus outcome relationships for developing future treatment planning strategies. Additionally, accurately assessing microsphere distributions is important because of concerns for unexpected activity deposition outside the liver. Quantitative 90Y imaging by

Purpose: This study explored whether complement factor 3 (C3) in plasma is associated with incidence of diabetes in a population-based cohort. We also identified genetic variants related to C3 and explored whether C3 and diabetes share common genetic determinants.Methods: C3 was analyzed in plasma from 4368 nondiabetic subjects, 46 to 68 years old, from the Malmö Diet and Cancer Study. Incidence o

PURPOSE. To determine if corneal subbasal nerve plexus (SBP) parameters derived from widearea depth-corrected mosaic images are associated with type 2 diabetes. METHODS. One hundred sixty-three mosaics were produced from eyes of 82 subjects by laserscanning in vivo confocal microscopy (IVCM). Subjects were of the same age, without (43 subjects) or with type 2 diabetes (39 subjects). Mosaic corneal

För ett stort antal elever i ungdoms- och vuxenutbildning gäller det attta sig an den komplexa uppgiften att både utveckla kunskaper i olikaämnen och att erövra ett helt nytt språk: svenska. Språktillägnandetbehöver understödjas på allra bästa sätt för att nå en nivå som kan mötade höga språkliga krav som ställs inom utbildning, yrkesliv och samhälle.Detta ställer i sin tur stora krav på andrasprå

Importance: Evidence is lacking regarding the consequences of antibiotic use in early life and the risk of certain autoimmune diseases.Objective: To test the association between early-life antibiotic use and islet or celiac disease (CD) autoimmunity in genetically at-risk children prospectively followed up for type 1 diabetes (T1D) or CD.Design, Setting, and Participants: HLA-genotyped newborns fr

OBJECTIVES: To analyze perinatal outcomes after maternal use of attention-deficit/ hyperactivity disorder (ADHD) medication during pregnancy. METHODS: The study included singletons born between 2006 and 2014 in Sweden. Data on prescription drug use, pregnancies, deliveries, and the newborn infants' health were obtained from the Swedish Medical Birth Register, the Prescribed Drug Register, and the

Background - Aortic valvular stenosis (AS) is the most common cause of cardiac valvular replacement surgery. During the last century, the pathogenesis of AS has undergone transitions in developed countries, from rheumatic heart disease to a degenerative calcific pathogenesis. Although a familial component has been described for a subset of cases with a bicuspid valve, data are limited on the overa

Supplemental Instruction is one of the most successful programmes of peer-assisted study in existence. Numerous studies show that SI attendance correlates with student achievement, regardless of the level of knowledge of the student prior to commencing their studies. The present study, from Humanities at Lund University, Sweden, outlines a method for gauging the effect of SI on soft values such as

Kapitlet beskriver en övning lämplig för studenter i kurser om socialt entreprenörskap. Övningen tillämpar tekniker för kommunikation för att erhålla donationer från olika intressenter.

En av utmaningarna för lärare är att känna igen språkfel som en del av språkutvecklingen. Eftersom normen i klassrummet ofta är språklig korrekthet kan det vara svårt att urskilja utvecklingen. Synen på inlärarspråket som ett eget språk snarare än en sämre variant av målspråket samt kunskap om typiska drag i inlärarspråket ökar möjligheterna att se den utveckling som faktiskt sker hos eleverna, vi

Boken presenterar på ett populärt sätt forskningsresultat från arkeologi, geologi och historieforskning. Det geografiska perspektivet omfattar Skåne under förhistorisk tid men därefter Kävlinge socken. Uppgiften om ett slag på Kävlingebro omkring 1020 föranledde en arkeologisk undersökning vilket presenteras. Lantbrukets utveckling utgör en viktig tråd i boken. Rikt illustrerad.

Objective: Sensation is essential for recovery after peripheral nerve injury. However, the relationship between sensory modalities and function of regenerated fibers is uncertain. We have investigated the relationships between touch threshold, tactile gnosis, and mechanoreceptor and sensory fiber function after nerve regeneration. Methods: Twenty-one median or ulnar nerve lesions were repaired by

BACKGROUND: Malignant mesothelioma (MM) is an aggressive, fatal tumor. Current therapeutic options only marginally improve survival. Programmed cell death ligand 1 (PD-L1) is a dominant mediator of immunosuppression, binding to programmed cell death 1 (PD-1). PD-L1 is up-regulated in cancer cells, and the PD-1/PD-L1 pathway plays a critical role in tumor immune evasion, thus providing a target for

Heart failure (HF) is the end-stage of all heart disease and arguably constitutes the greatest unmet therapeutic need in cardiovascular medicine today. Classic epidemiological studies have established clinical risk factors for HF, but the cause remains poorly understood in many cases. Biochemical analyses of small case-control series and animal models have described a plethora of molecular charact

En källa från Ryds klosters årsbok skriver om slaget på Kävlingebro cirka 1020. Invid broläget påträffades en cirkulär anläggning som efter arkeo-/ geologiska undersökningar visade sig vara en kreatursfålla. Artikeln söker anledningen til det eventuella slaget och fållans funktion i närområdet. Ulf jarls härkomst till norra Skåne prövas.