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Thermal stress analysis of solid oxide fuel cells with chromium poisoning cathodes

Chromium(Cr) poisoning of the traditional LSM cathode is one of the most critical issues that accounts for instability of solid oxide fuel cells (SOFCs). The poisoning course will introduce alien species in the cathode active regions and it causes phase change and structure deformation, reducing the sites for electrochemical reactions. A 3D model is thus developed by coupling the computational flu

Does inflammation have a role in migraine?

Migraine is a prevalent disorder, affecting 15.1% of the world’s population. In most cases, the migraine attacks are sporadic; however, some individuals experience a gradual increase in attack frequency over time, and up to 2% of the general population develop chronic migraine. The mechanisms underlying this chronicity are unresolved but are hypothesized to involve a degree of inflammation. In thi

Potential effects of increased openness in pharma : the original knowledge behind new drugs

This study seeks to determine potential changes in the degree of openness in pharmaceutical R&D by investigating where the knowledge behind new molecular entities (NMEs) comes from in terms of type of organization, geography and time. We find that the organizations granted NMEs increasingly rely on external knowledge sources but that these are increasingly shared among NME grantees. Universiti

Low Production of Reactive Oxygen Species Drives Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is a common autoimmune disease. Recent findings have shown that a major single nucleotide variant predisposing to SLE is associated with low production of reactive oxygen species (ROS). A variant amino acid in a frequent NCF1 allele causing deficient ROS production leads to an exaggerated type I interferon (IFN) response, earlier disease onset, and higher suscept

Sequence of 305,996 total hip and knee arthroplasties in patients undergoing operations on more than 1 joint

Background and purpose — Patient-specific data on multiple total arthroplasties (TA) of the lower limbs due to osteoarthritis (OA) are limited. We investigated the sequence of surgical procedures and risk factors for additional surgery in such patients. Patients and methods — 305,996 patients operated with a TA of the hip and/or knee due to OA were extracted from the Swedish National Hip (SHAR) an

Multimodal cue integration in the dung beetle compass

South African ball-rolling dung beetles exhibit a unique orientation behavior to avoid competition for food: after forming a piece of dung into a ball, they efficiently escape with it from the dung pile along a straight-line path. To keep track of their heading, these animals use celestial cues, such as the sun, as an orientation reference. Here we show that wind can also be used as a guiding cue

National policies and social inequalities in exit paths from working life in Sweden

We investigated the impact on work life exits from reduced access to disability pension (2006), and financial incentives to extend working life. Method and materialWe used labour statistics of all employees in Sweden, Social insurance and income data, to compare occupational groups (SSYK, based on ISCO-88), and blue and white collar workers, with regard to i) lost years in working life due to deat

Night and Organization Studies

In this essay, I want to shed light on the phenomena of night and nightwork as important topics which have been so far overlooked in organization studies. Inspired by insights of new materialism (Barad), I propose and investigate night as ‘time-space’, and present intertwined dimensions (temporal, spatial, social, material, etc.) of intra-actions between human beings and night. To better understan

Factors related to health-related quality of life in older people with multimorbidity and high health care consumption over a two-year period

BACKGROUND: The prevalence of multimorbidity is increasing worldwide, and older people with multimorbidity are frequent users of health care services. Since multimorbidity has a significant negative impact on Health-related Quality of Life (HrQoL) and is more common in older age it would be expected that factors related to HrQoL in this group might have been thoroughly researched, but this is not

Experiences of using a video-based learning model during a long-term process of movement awareness and learning–a hermeneutical study

Aim: To explore the long-term learning process in movement awareness development supported by a video-based learning model. Participants: Eleven undergraduate nursing students. Method: The students participated in learning sessions comprising video modelling, video feedback and reflective enquiry with a focus on inter-personal interaction. Each student participated in three individual video sessio

Designing stem-cell-based dopamine cell replacement trials for Parkinson’s disease

Clinical studies of Parkinson’s disease (PD) using a dopamine cell replacment strategy have been tried for more than 30 years. The outcomes following transplantation of human fetal ventral mesencephalic tissue (hfVM) have been variable, with some patients coming off their anti-PD treatment for many years and others not responding and/or developing significant side effects, including graft-induced

The specific organism : Not bacterial gram type: Drives the inflammatory response in septic shock

Background and Hypothesis: The inflammatory response was targeted by unsuccessful therapies but ignored pathogen. We hypothesized that the inflammatory response differs according to organism in human septic shock. Materials and Methods: We measured 39 cytokines at baseline and 24 h in patients (n = 363) in the Vasopressin and Septic Shock Trial (VASST). We compared cytokine profiles (cytokine func

When and Where Birth Spacing Matters for Child Survival: An International Comparison Using the DHS

A large body of research has found an association between short birth intervals and the risk of infant mortality in developing countries, but recent work on other perinatal outcomes from highly developed countries has called these claims into question, arguing that previous studies have failed to adequately control for unobserved heterogeneity. Our study addresses this issue by estimating within-f

Breast-feeding during Pregnancy and the Risk of Miscarriage

ContextBreastfeeding rates and durations have been increasing among American women in recent decades, but a consequence of these trends is that women may be more likely to practice breastfeeding during pregnancy (BDP). BDP has been hypothesized to increase the risk of miscarriage, yet there has been little research investigating if this is the case.MethodsUsing data on 10,661 pregnancies from the

Germline variants in oculocutaneous albinism genes and predisposition to familial cutaneous melanoma

Approximately 1%–2% of cutaneous melanoma (CM) is classified as strongly familial. We sought to investigate unexplained CM predisposition in families negative for the known susceptibility genes using next-generation sequencing of affected individuals. Segregation of germline variants of interest within families was assessed by Sanger sequencing. Several heterozygous variants in oculocutaneous albi

Carbonic anhydrases in human keratinocytes and their regulation by all-trans retinoic acid and 1α,25-dihydroxyvitamin D3

Carbonic anhydrases (CAs) are ubiquitously expressed enzymes and catalyse an important physiological reaction of interconverting the hydration of carbon dioxide to bicarbonates, which is crucial for maintaining acid/base equilibrium in certain tissues. While 15 different isoforms of CAs are present in various cell types in human tissues, their expression pattern in the epidermis remains to be inve

Paleoproteomics of Mesozoic Dinosaurs and Other Mesozoic Fossils

Molecular studies have contributed greatly to our understanding of evolutionary processes that act upon virtually every aspect of living organisms. However, these studies are limited with regard to extinct organisms, particularly those from the Mesozoic because fossils pose unique challenges to molecular workflows, and because prevailing wisdom suggests no endogenous molecular components can persi