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Automated Bone Scan Index as a quantitative imaging biomarker in metastatic castration-resistant prostate cancer patients being treated with enzalutamide.

Having performed analytical validation studies, we are now assessing the clinical utility of the upgraded automated Bone Scan Index (BSI) in metastatic castration-resistant prostate cancer (mCRPC). In the present study, we retrospectively evaluated the discriminatory strength of the automated BSI in predicting overall survival (OS) in mCRPC patients being treated with enzalutamide.

Infantile colic, maternal smoking and infant feeding at 5 weeks of age.

BACKGROUND: Many parents seek help from health professionals because of their infants' persistent crying in the early months. The aetiology of this condition, often labelled ;;infantile colic'', is still unclear. AIMS: To assess whether smoking during pregnancy, and/or smoking at infant age 5 weeks, is associated with infantile colic, and to describe how feeding at infant age 5 weeks and smoking a

Jesus -- vår syster och broder

The fact that Jesus was a man is claimed to be problematic from a feministic standpoint. One aspect of what is problematic is that the conception of Jesus as the Christ, representing God, makes the connection between men and God closer that that between women and God. In terms of religious proximity men are given a higher degree of religious proximity and therefore also religious authority by mean

Carotenoid cation formation and the regulation of photosynthetic light harvesting

Photosynthetic light harvesting in excess light is regulated by a process known as feedback deexcitation. Femtosecond transient absorption measurements on thylakoid membranes show selective formation of a carotenoid radical cation upon excitation of chlorophyll under conditions of maximum, steady-state feedback deexcitation. Studies on transgenic Arabidopsis thaliana plants confirmed that this car

Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene.

To comprehensively characterize microRNA (miRNA) expression in breast cancer, we performed the first extensive next-generation sequencing expression analysis of this disease. We sequenced small RNA from tumors with paired samples of normal and tumor-adjacent breast tissue. Our results indicate that tumor identity is achieved mainly by variation in the expression levels of a common set of miRNAs ra

Application of nitric oxide measurements in clinical conditions beyond asthma.

Fractional exhaled nitric oxide (FeNO) is a convenient, non-invasive method for the assessment of active, mainly Th2-driven, airway inflammation, which is sensitive to treatment with standard anti-inflammatory therapy. Consequently, FeNO serves as a valued tool to aid diagnosis and monitoring in several asthma phenotypes. More recently, FeNO has been evaluated in several other respiratory, infecti

Routine diagnostic patch-testing with formaldehyde 2.0% (0.6 mg/cm2) may be an advantage compared to 1.0%.

Our clinical experience has suggested that the presently recommended patch-test concentration (1.0%) for formaldehyde in the baseline series might be too low. Therefore, consecutively patch-tested dermatitis patients were tested simultaneously with formaldehyde 1.0% and 2.0% (w/v) in aqua. Formaldehyde 1.0% and 2.0% were applied with a micro-pipette (15 microl) to filter paper discs in Finn Chambe

Changes in forearm bone mass and bone size after menopause - A mean 24-year prospective study.

Objective: Bone loss and periosteal expansion is found after menopause. The accelerated early postmenopausal bone loss is not permanent but if the same accounts for the periosteal expansion is unknown. Methods: Bone mineral density (BMD) and skeletal structure of the distal forearm were followed from menopause and on average 24 years (range 18-28) by single-photon absorptiometry at 12 occasions in

Social Characterology. From the Protestant Ethic, via the Social Ethic, to the Hacker Ethic

Starting out from Max Weber's "The Protestant Ethic" the article focuses on a number of authors – David Riesman, William H. Whyte, Daniel Bell and Pekka Himanen – who have used that book as a reference point in their endeavours to capture the spirit of their time. Key themes in the article are ways of life, the formation of social character and charcterological struggle.