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Prognostic biomarkers in upper gastrointestinal adenocarcinoma

Estimates indicate that the global cancer burden may be ever-increasing. Gastric cancer is one of the major cancer forms. Despite its declining incidence, the high mortality of gastric cancer makes it the third most common cause of cancer-related death. Esophageal cancer is less common, but the incidence is increasing in parts of the world. Although some progress has been made in the treatment of

Distinct global binding patterns of the Wilms' tumor gene 1 (WT1) -KTS and +KTS isoforms in leukemic cells

The zinc finger transcription factor Wilms' tumor gene 1 (WT1) acts as an oncogene in acute myeloid leukemia. A naturally occurring alternative splice event between zinc fingers three and four, removing or retaining three amino acids (+/-KTS), is believed to change the DNA binding affinity of WT1, although there are conflicting data regarding the binding affinity and motifs of the different isofor

Tracking of Wideband Multipath Components in a Vehicular Communication Scenario

A detailed understanding of the dynamic processes of vehicular radio channels is crucial for its realistic modeling. In this paper, we present multipath components (MPCs) tracking results from a channel sounder measurement with 1-GHz bandwidth at a carrier frequency of 5.7 GHz. We describe in detail the applied algorithms and perform a tracking performance evaluation based on artificial channels a

Making sense of adsorption : Attempting to explain the adsorption of histatin 5 with models, metaphors, and machines

This thesis summarises two studies in which the main purpose was to find out how and why the amount of the protein histatin 5 that adsorbs to negatively charged surfaces changes with pH and ionic strength. Histatin 5 is an intrinsically disordered saliva protein, and in the oral environment it adsorbs to tooth enamel. The approach here is to simplify the biological system by using an aqueous buffe

Measurement-Based Wideband Analysis of Dynamic Multipath Propagation in Vehicular Communication Scenarios

Realistic propagation modeling requires a detailed understanding and characterization of the radio channel properties. This paper is based on channel sounder measurements with 1 GHz bandwidth at a carrier frequency of 5.7 GHz and particular tracking methods. We present statistical models for the number of, birth rate, lifetime, excess delay and relative Doppler frequency of individual multipath co

Enhancement of oogenesis/spermatogenesis in meagre Argyrosomus regius using a combination of temperature control and GnRHa treatments

A multiple GnRHa injection method for inducing spawning of high fecundity and quality in meagre was optimized. Specifically, the study (a) examined how long females would continue spawning in response to consecutive, weekly GnRHa injections, if maintained at the natural spawning temperature, and (b) evaluated whether males can produce adequate amounts of good quality sperm for the same period, wit

Artificial Intelligence and the City : urbanistic Perspectives on AI

This book explores in theory and practice how artificial intelligence (AI) intersects with and alters the city. Drawing upon a range of urban disciplines and case studies, the chapters reveal the multitude of repercussions that AI is having on urban society, urban infrastructure, urban governance, urban planning and urban sustainability.Contributors also examine how the city, far from being a pass

Models for Non-Modelers : Understanding the Use of Models for Social Scientists and Others

Models for Non-Modelers focuses not on how to design models but on how to understand and critically appraise them. Data and statistical models are widely used in disciplines such as epidemiology, climate science and systems design, but it can be difficult for those without the necessary training to understand and implement them. This book is for non-modelers, especially social scientists. Through

Provsamlingen Swecrit och AI ger ny kunskap vid intensivvård

The unique Swecrit Biobank and its associated clinical registries for sepsis, ARDS, cardiac arrest, trauma, and COVID-19 include more than 150,000 blood samples and descriptions of critically ill patients. These assets provide a unique opportunity to research and improve the care of the most seriously ill patients through biomarker analyses, proteomic studies, and genetic and epigenetic studies us

A TDLAS-based photofragmentation method for spatially resolved measurement of KOH and KCl as well as its application in biomass combustion processes

The release of gas-phase potassium species, mainly KOH, KCl, and K atoms, from burning biomass fuels can introduce severe problems to boilers, such as fouling, slagging, and corrosion. In the present work, an optical technique combining laser-induced photofragmentation and tunable diode laser absorption spectroscopy is developed for simultaneously measuring the concentration of KOH, KCl and K atom

Combustion of micron-sized Al-Mg alloy wires in hot H2O/O2/N2 flows

The use of aluminum-magnesium (Al-Mg) alloy particle as energetic additive in solid propellants was previously shown to have many advantages over pure Al particle, such as relatively low ignition temperature, high reaction rate and low particle agglomeration rate. In this paper, the combustion of Al-Mg alloy in hot H2O/O2/N2 flows was experimentally studied using wires with a diameter of 200 µm. T

Gestational hypertension, preeclampsia, and gestational diabetes mellitus after high exposure to perfluoroalkyl substances from drinking water in Ronneby, Sweden

Background: Leakage of fire-fighting foam from an airfield caused contamination of the drinking water supplied to a third of the population in Ronneby, resulting in very high serum levels of predominantly perfluorooctane sulfonate (PFOS) and perfluorohexane sulfonate (PFHxS). The results of studies investigating the association between exposure to perfluorinated alkyl substances (PFAS) and pregnan

Laser Diagnostics in Reacting Flows

Burst-mode laser systems have widely been employed in diagnostics for both reactive and non-reactive flows. Unlike the continuous pulse lasers, burst-mode lasers generate pulses in bursts lasting up to 100 ms, capable to deliver high energies up to Joules per pulse. This high energy fluency is optimal for effective wavelength conversion and tuning, enabling simultaneous measurements of various spe