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Chemometric analysis of NMR spectra

NMR is one of the most powerful analytical techniques of our time. It allows detailed investigation of qualitative and quantitative characteristics of complex chemical and biological samples. The resulting NMR data provides a wealth of information about the samples, but the NMR data analysis has been and still is suffering from oversimplified approaches making it difficult to extract all the infor

Palatal Sound : A Comprehensive Model of Vocal Tract Articulation

Palatal Sound is a model of vocal tract articulation influenced by physiologic and acoustic analysis of the voice. Specifically, the term articulation refers to all movement within the vocal tract that results in open, filter-like sonorities, as well as in turbulent to absolute airflow modification. This model presents a complete mapping of place within the vocal tract that features flexibility ac

Modeling of temperature dependence of stress-reorientation of hydrides in CWSR Zr-alloys

Hydrogen in excess of solid solubility precipitates as hydride phase of plate shaped morphology in hcp α-Zr with the broad face of the hydride plate coinciding with certain crystallographic plane of α-Zr crystal called habit plane. The objective of the present investigation is to predict the habit plane of δ-hydride precipitating in α-Zr at 298 K using strain energy minimization technique. The δ-h

Pattern recognition of nerve signals using an artificial neural network

By using a microfabricated nerve chip with integrated electrodes through which peripheral nerves can generate and make electrical connects, it should be possible to control a remote prosthesis by processing the detected nerve signals. In this study different artificial neural networks have been employed for classification of such complex patterns of signals. The signals were obtained from four ele

Selective immunolesioning of the basal forebrain cholinergic system disrupts short-term memory in rats

Selective depletion of nerve growth factor receptor-bearing neurons in the basal forebrain cholinergic system nuclei by the immunotoxin 192 IgG-saporin offers a new and highly useful tool for the study of the role of the forebrain cholinergic system in cognitive functions. In the present study, we have tested the effects of 192 IpG-saporin in an operant delayed matching-to-position task which has

Real-time metabolomic analysis of lactic acid bacteria as monitored by in vitro NMR and chemometrics

Introduction: Lactic acid bacteria (LAB) play an important role in the food industry as starter cultures to manufacture fermented food, and as probiotics. In recent years, there has been an increasing interest in using LAB cultures for biopreservation of food products. It is therefore of great interest to study the detailed metabolism of these bacteria. Objectives: This study aimed at developing a

Metabolic footprinting for investigation of antifungal properties of Lactobacillus paracasei

Lactic acid bacteria with antifungal properties are applied for biopreservation of food. In order to further our understanding of their antifungal mechanism, there is an ongoing search for bioactive molecules. With a focus on the metabolites formed, bioassay-guided fractionation and comprehensive screening have identified compounds as antifungal. Although these are active, the compounds have been

Quantitative determination of mold growth and inhibition by multispectral imaging

Quantifying mold growth is of great relevance and interest in microbiology. However, predictive modeling of filamentous fungal growth has been hampered by the lack of an appropriate and accurate method for quantification. An adequate, rapid and objective method will allow studying the effect of many different parameters and conditions on mold growth patterns and can thus provide valuable insight a