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Multiple myeloma is a heterogeneous hematological disease that originates from the bone marrow and is characterized by the monoclonal expansion of malignant plasma cells. Despite novel therapies, multiple myeloma remains clinically challenging. A common feature among patients with poor prognosis is the increased activity of the epigenetic silencer EZH2, which is the catalytic subunit of the PRC2.

BACKGROUND: An increasing number of monogenic conditions underlying stroke are being identified. We explored the possibilities of increasing the diagnostic yield of monogenic stroke in a population under 56 years of age. METHODS: Fifty probands ≤55 years at their first stroke episode were characterized clinically and investigated by whole genome sequencing. Probands had one or more of: (1) one or

The proof of the pudding lies in eating, and that is why 6G testbeds are essential in the progress toward the next generation of wireless networks. Theoretical research toward 6G wireless networks proposes advanced technologies to serve new applications and drastically improve energy performance. Testbeds are indispensable to validate these new technologies under more realistic conditions. This ar

Prostate Cancer Diagnosis and Treatment Enhancement through the Power of Big Data in Europe (PIONEER) is a European network of excellence for big data in prostate cancer. PIONEER brings together 34 private and public stakeholders from 9 countries in one multidisciplinary research consortium with the aim of positively transforming the field of prostate cancer clinical care by answering pressing que

Background: Calcitonin gene-related peptide (CGRP) is part of the calcitonin peptide family, which includes calcitonin (CT), amylin (AMY), and adrenomedullin (ADM). CGRP and its receptor are highly present in the trigeminovascular system (TVS). Recent research suggests that other members of the calcitonin family could be feasible therapeutic targets in the treatment of migraine. The present study

Cities and local governments are increasingly under pressure to accelerate transformative change in energy and climate transitions. To help cities in their climate actions, the European Commission (EC) has established the EU Cities Mission, which aims for climate neutrality by 2030 for participating cities. The literature argues that one of the main obstacles to accelerating decarbonization lies i

Aim: This position paper focuses on healthy ageing for the frailest and institutionalized older adults in the context of the recent pandemic. The paper aims to identify and discuss hindering and promoting factors for healthy ageing in this context, taking both health safety and a meaningful social life into account, in a pandemic situation and beyond. Background: The recent COVID-19 pandemic has h

In Sweden's upper secondary school aesthetic program, educators face significant opportunities and challenges in teaching students who utilize Electronical Digital Instruments (EDI) as their primary instrument. Since 2017, students have leveraged EDI, employing computers, user-configured software, and performance controllers to play and create music. This transformative approach challenges traditi

Context. Stellar tidal streams are a key tracer of galaxy evolution and have the potential to provide an indirect means for tracing dark matter. For the Local Group, many diffuse substructures have been identified and their link to galaxy evolution has been traced. However, the Local Group does not offer a statistically significant sample of stellar tidal streams. Thus, an analysis of a larger sam

Results from a wide range of searches targeting different experimental signatures with and without missing transverse momentum (ETmiss) are used to constrain a Two-Higgs-Doublet Model (2HDM) with an additional pseudo-scalar mediating the interaction between ordinary and dark matter (2HDM+a). The analyses use up to 139 fb−1 of proton–proton collision data at a centre-of-mass energy s=13 TeV recorde

The rise of scientific inquiry focusing on bilingualism over the past few decades has also borne witness to an increase in the study of individuals and communities who speak a native language that is not the sociolinguistically dominant language of the environment in which they grew up. While it is common practice to refer to these diverse groups and individuals as “heritage speakers”, it is uncle

We study dialectal influence and gender marking in 25 bilectal children and 11 adults speaking Italian and Venetan, based on an elicited production task (EPT) in each of the two varieties. The children are between 5 and 11 years old and vary with respect to their reported use of the dialect at home. The results of the EPT show that the children produce only Italian DPs in the Italian experiment, w

Many water treatment processes used to improve the quality of drinking- and wastewater directly or indirectly affect, or are affected by, the activity of microbes. These activities can improve water quality, presenting sustainable alternatives to mechanical or chemical processes. As water is distributed, it is also changed by microbes. Harnessing the potential of microbes to improve water quality Many water treatment processes used to improve the quality of drinking- and wastewater directly or indirectly affect, or are affected by, the activity of microbes. These activities can improve water quality, presenting sustainable alternatives to mechanical or chemical processes. As water is distributed, it is also changed by microbes. Harnessing the potential of microbes to improve water quality