Amyloid plaques and neurofibrillary tangles (NFTs) in the brain are the neuropathological hallmarks of Alzheimer's disease (AD). Amyloid plaques are composed of β-amyloid peptides (Aβ), while NFTs contain hyperphosphorylated tau proteins. Patients with familial AD who have mutations in the amyloid precursor protein (APP) gene have either increased production of Aβ or generate more aggregation-pron

Debattartikel i Sydsvenska Dagbladet där jag argumenterar för att det är svenska institutioner som bär svenska värderingar, snarare än enskilda individer. Det bästa sättet att verka för svenska värderingar är därför att verka för att institutionerna är starka och närvarande i hela det svenska samhället.

This study suggests an optimization framework to plan and design a network of bike lanes in an urban context, based on equity principles and subject to a given available budget. The novelty of the proposal consists in an objective function that aims at minimizing the existing inequities among different population groups in terms of accessibility/opportunity to the bikeways. The proposed methodolog

AIMS/HYPOTHESIS: Endoplasmic reticulum (ER) stress has been implicated in the development of type 2 diabetes, via effects on obesity, insulin resistance and pancreatic beta cell health. C/EBP homologous protein (CHOP) is induced by ER stress and has a central role in apoptotic execution pathways triggered by ER stress. The aim of this study was to characterise the role of CHOP in obesity and insul

This chapter discusses the history of the modern German university and the topicality of Wilhelm von Humboldt’s ideas. A key issue is how the Humboldtian tradition, with its origin in Prussia around the year 1800, was transformed and has informed debates about research, higher education and academic freedom ever since. Drawing on recent scholarship, this chapter investigates the ways in which Humb

Accurate knowledge about the amount and dynamics of terrestrial gross primary productivity is an important component for understanding of ecosystem functioning and processes. Recently a new diagnostic model, Southampton Carbon Flux (SCARF), was developed to predict terrestrial gross primary productivity at regional to global scale based on a chlorophyll index derived from MERIS data. The model aim

Conventional osteosarcoma is the most common primary malignancy of bone. This group of neoplasms is subclassified according to specific histological features, but hitherto there has been no correlation between subtype, treatment, and prognosis. By in-depth genetic analyses of a chondroblastoma-like osteosarcoma, we detect a genetic profile that is distinct from those previously reported in benign

INTRODUCTION: Patients with depression have significantly increased mortality from somatic disease. The purpose of this article was to review studies that investigate if there is a prognostic association with depression as co-morbidity in patients with chronic obstructive pulmonary disease (COPD). We chose the following outcomes: mortality, suicide behaviour, risk of COPD exacerbation, use of prim

Background:For software-intensive organizations, Open Source Software (OSS) may provide a pivotal building block in business models and strategies, product and service offerings, as well as in tool and infrastructure setups. The Requirements Engineering (RE) and development processes of OSS take place inside communities where the focal organization is a stakeholder among many, including competitor

Carina Ehrenholms farbror Göte föddes 1926 och var genom hela sitt liv en brinnande kommunist. När han var tjugo år såg han på framtiden med otroligt stor tillförsikt och optimism. Industrin blomstrade och den socialdemokratiska reformpolitiken hade verkligen slagit rot i den svenska folksjälen. Läget blev, som i Karl-Gerhards populära melodi, bättre och bättre dag för dag. Göte dog hösten 2016, s

This chapter of the 'Flavor in the era of LHC' workshop report discusses flavor-related issues in the production and decays of heavy states at the LHC at high momentum transfer Q, both from the experimental and the theoretical perspective. We review top quark physics, and discuss the flavor aspects of several extensions of the standard model, such as supersymmetry, little Higgs models or models wi