Importance: Multiple myeloma is consistently preceded by monoclonal gammopathy of undetermined significance (MGUS). Risk models that estimate the risk of progression from MGUS to multiple myeloma use data from a single time point, usually the initial workup. Objective: To longitudinally investigate the alterations of serum immune markers with stable vs progressive MGUS. Design, Setting, and Partic

Grating-based X-ray dark-field contrast is an emerging new imaging modality that is demonstrating particularly high potential for radiography. The signal in dark-field X-ray imaging is determined by small-angle X-ray scattering at structures typically below the spatial resolution of the imaging setup. Thus, this technique not only yields complementary information but also visualizes information th

The formation of the nuclear envelope and the subsequent compartmentalization of the genome is a defining feature of eukaryotes. Traditionally, the nuclear envelope was purely viewed as a physical barrier to preserve genetic material in eukaryotic cells. However, in the last few decades, it has been revealed to be a critical cellular component in controlling gene expression and has been implicated

Electroactive microorganisms possess the unique ability to transfer electrons to or from solid phase electron conductors, e.g., electrodes or minerals, through various physiological mechanisms. The processes are commonly known as extracellular electron transfer and broadly harnessed in microbial electrochemical systems, such as microbial biosensors, microbial electrosynthesis, or microbial fuel ce

Goals concerning reduced car traffic are found in most European cities, indicating a potential change in local transport policy and land use planning, which have traditionally been very car-centric. This paper analyses goals and measures to reduce car traffic in Swedish municipalities’ long-term transport and land use plans. Theoretically, the paper is based on an understanding of policies as part

This book is in honour of Professor Anna-Sofia Maurin on her 50th birthday. It consists of eighteen essays on metaphysical issues written by Swedish and international scholars.

If resolving the global environmental cns1s were simply a matter of 'techniques', in other words installing new production technologies, converting to zero-emissions vehicles, using less packaging, changing to 'green' fiscal policies and strengthening emissions laws. then why haven't we already implemented them? The technical principles of a shift to a sustainable society are simple and straightfo

This thesis is concerned with spoken dialogue and the dynamic negotiation of meaning in English conversation. It serves two aims, one theoretical and the other practical. The theoretical aim is to further our understanding of the kinds of properties that influence the meaning of constructions in spoken dialogue and the role of underlying socio-cognitive processes. The practical aim is to compile a

The Learning with Errors problem (LWE) is one of the main candidates for post-quantum cryptography. At Asiacrypt 2017, coded-BKW with sieving, an algorithm combining the Blum-Kalai-Wasserman algorithm (BKW) with lattice sieving techniques, was proposed. In this paper, we improve that algorithm by using different reduction factors in different steps of the sieving part of the algorithm. In the Rege

H-kininogen (high-molecular-mass kininogen, HK) is the precursor of the vasoactive peptide hormone bradykinin (BK). Previous work has demonstrated that HK binds to Streptococcus pyogenes through M-proteins, fibrous surface proteins and important virulence factors of these bacteria. Here we find that M-protein-expressing bacteria absorb HK from human plasma. The HK bound to the bacteria was found t

Abstraktinlämning NutritionGastrodagarna-1027Fortsatta erfarenheter av teduglutidbehandling vid extrema kort tarm syndrom i skåne och blekinge.Å Nilsson* 1, G Hoffmann2, M Söderholm3, L Zhou11Gastroenterologisektionen, Skånes Universitetssjukhus, Lund, 2Medicin, Gastroenterologi, Centralsjukhuset, Kristianstad, 3Kirurgiska Kliniken, Blekingesjukhuset, Karlskrona, SverigeBakgrund: Teduglutid (Reves

In this work we develop a computer-aided diagnosis (CAD) scheme for classification of pulmonary disease for grating-based x-ray radiography. In addition to conventional transmission radiography, the grating-based technique provides a dark-field imaging modality, which utilizes the scattering properties of the x-rays. This modality has shown great potential for diagnosing early stage emphysema and

In this study analysis of magnesium in mononuclear cells was compared to that in muscle in patients and healthy controls. Mononuclear cell concentrations of magnesium expressed as nmol/mg cell protein correlated significantly with muscle biopsy concentrations of magnesium (r = 0,68; p less than 0,001). Hence, we suggest that analyzing of magnesium in mononuclear cells could be an easy and convenie

On-line hyphenation of extraction with chromatography has been explored in several different types of combinations. However, monitoring the complete process of a dynamic, continuous-flow extraction is not possible with any hyphenated system reported so far. The current work demonstrates that this challenging task can be effectively fulfilled by using a parallel sampling interface, which mimics the