Aims Optimal antithrombotic therapy after percutaneous coronary intervention (PCI) in patients with myocardial infarction (MI) and atrial fibrillation is uncertain. In this study, we compared antithrombotic regimes with regard to a composite cardiovascular outcome of all-cause mortality, MI or ischaemic stroke, and major bleeds. Methods and results Patients between October 2005 and December 2012 w

Aim: Having a known midwife at birth is valued by women across the world, however it is unusual for women with fear of childbirth to have access to this model of care. The aim of this study was to describe the prevalence and factors related to having access to a known midwife for women referred to counseling due to childbirth fear. We also wanted to explore if women's levels of childbirth fear cha

At the southern margin of permafrost in North America, climate change causes widespread permafrost thaw. In boreal lowlands, thawing forested permafrost peat plateaus (‘forest’) lead to expansion of permafrost‐free wetlands (‘wetland’). Expanding wetland area with saturated and warmer organic soils is expected to increase landscape methane (CH4) emissions. Here, we quantify the thaw‐induced increa

Over the last several decades the hydrologically sensitive Boreal Plains ecoregion of Western Canada has experienced significant warming and drying. To better predict implications of land cover changes on evapotranspiration (ET) and future water resources in this region, high resolution light detection and ranging and energy balance data are used here to spatially parameterize the Penman-Monteith

Spaceborne laser altimetry waveform estimates of canopy Gap Fraction (GF) vary with respect to discrete return airborne equivalents due to their greater sensitivity to reflectance differences between canopy and ground surfaces resulting from differences in footprint size, energy thresholding, noise characteristics and sampling geometry. Applying scaling factors to either the ground or canopy porti

The Geoscience Laser Altimeter System (GLAS) has the potential to accurately map global vegetation heights and fractional cover metrics using active laser pulse emission/reception. However, large uncertainties in the derivation of data products exist, since multiple physically plausible interpretations of the data are possible. In this study a method is described and evaluated to derive vegetation

Pseudouridylation (Ψ) is the most abundant and widespread type of RNA epigenetic modification in living organisms; however, the biological role of Ψ remains poorly understood. Here, we show that a Ψ-driven posttranscriptional program steers translation control to impact stem cell commitment during early embryogenesis. Mechanistically, the Ψ “writer” PUS7 modifies and activates a novel network of t

In the sporadic permafrost zone of northwestern Canada, boreal forest carbon dioxide (CO2) fluxes will be altered directly by climate change through changing meteorological forcing and indirectly through changes in landscape functioning associated with thaw‐induced collapse‐scar bog (‘wetland’) expansion. However, their combined effect on landscape‐scale net ecosystem CO2 exchange (NEELAND), resul

In Arctic fjords and high‐latitude seas, strong surface cooling dominates during a large part of the year, generating water‐side convection (w* w) and enhanced turbulence in the water. These regions are key areas for the global carbon cycle; thus, a correct description of their air‐sea gas exchange is crucial. CO2 data were measured via the eddy covariance technique in marine Arctic conditions and

Young children with visual impairments tend to engage less with their surroundings, limiting the benefits from activities at school. We investigated novel ways of using sound from a bracelet, such as speech or familiar noises, to tell children about nearby people, places and activities, to encourage them to engage more during play and help them move independently. We present a series of studies, t

Remodelling of the extracellular matrix is accomplished by altering the balance between matrix macromolecule production and degradation. However, it is not well understood how cells balance production of new matrix molecules and degradation of existing ones during tissue remodelling and regeneration. In this study, we used decellularized lung scaffolds repopulated with allogenic lung fibroblasts c

Apart from the relevant lipid-lowering effects, statins have demonstrated significant, although heterogeneous, anti-tumor activities in preventing breast cancer (BC) progression. To characterize the critical pathways behind the diverse responses to therapy, we investigated statin-induced changes in regulation of lipid metabolism and abundance of neutral lipid-containing cytoplasmic lipid droplets

The detailed mechanisms of progressive intensification of seizures often occurring in epilepsy are not well understood. Animal models of kindling, with progressive intensification of stimulation-induced seizures, have been previously used to investigate alterations in neuronal networks, but has been obscured by limited recording capabilities during electrical stimulations. Remote networks in kindl

In this paper we suggest an algorithm for estimation of the parameters detailing Oscillating Gaussian functions. The different components of the signal are first detected in the spectrogram. After this we exploit the fact that a Gaussian function may be perfectly reassigned into one single point given a correct scaling factor, where this scaling factor is a function of the unknown shape parameter