Furfuryl thioacetate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that furfuryl thioacetate is not genotoxic. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the threshold of toxicological concern (TTC

This paper presents an integrated simulation-based methodology for considering the effects of weather on formwork removal times. An expert tool for estimating formwork removal times and weather data with high resolution are integrated into a discrete-event simulation model containing a process model of in-situ concrete wall operations. In addition, operational measures (denoted as curing strategie

Background: It has become clear that healthcare workers are at high risk, and otolaryngology has been theorized to be among the highest risk specialties for coronavirus disease 2019 (COVID-19). The purpose of this study was to detail the international impact of COVID-19 among otolaryngologists, and to identify instructional cases. Methods: Country representatives of the Young Otolaryngologists–Int

Objective: In previous studies, atherosclerotic vascular events (AVEs) were shown to occur in ~10% of patients with systemic lupus erythematosus (SLE). We undertook this study to investigate the annual occurrence and potential risk factors for AVEs in a multinational, multiethnic inception cohort of patients with SLE. Methods: A large 33-center cohort of SLE patients was followed up yearly between

Background: Type 3 von Willebrand's disease (VWD) patients present markedly reduced levels of von Willebrand factor and factor VIII. Because of its rarity, the bleeding phenotype of type 3 VWD is poorly described, as compared to type 1 VWD. Aims: To evaluate the frequency and the severity of bleeding symptoms across age and sex groups in type 3 patients and to compare these with those observed in

We present a straightforward implementation of compressive imaging in femtosecond pump-probe spectroscopy. By using laser speckles as random patterns we built a single-pixel camera experiment capable of imaging processes with temporal resolution

Background: Swefoot is a Swedish national registry, that covers surgery in the foot and ankle. Surgical treatment of hallux rigidus (HR) vary within and between countries. The aim of this study was to report baseline variables for patients with HR. Methods: We extracted baseline characteristics, surgical procedures and patient-reported data for patients with HR entered in the registry during the p

Objectives: Study the effect of introducing a template for radiological reporting of non-enhanced computed tomography (NECT) in the primary care diagnostic work up of cognitive impairment using visual rating scales (VRS). Methods: Radiology reports were assessed regarding compliance with a contextual report template and the reporting of the parameters medial temporal lobe atrophy (MTA), white matt

Purpose: Neurofilament light (NfL) is a biomarker reflecting neurodegeneration and acute neuronal injury, and an increase is found following hypoxic brain damage. We assessed the ability of plasma NfL to predict outcome in comatose patients after out-of-hospital cardiac arrest (OHCA). We also compared plasma NfL concentrations between patients treated with two different targets of arterial carbon

This report presents an integrated simulation-based approach to study the on-site production of concrete frameworks by considering the multiple effects of weather on work task productivity and concrete curing process. The suggested approach enable to systematically study how different weather conditions and the use of climate-improved concrete in combination with different methods to shield concre

The construction workflow of in-situ concrete frames in multi-storey residential buildings is highly complex and dynamic. Discrete-event simulation (DES) offers capabilities to model and analyse such complexity. Although DES has successfully been used by researchers in a wide range of construction-related applications there are not many examples demonstrating how different simulation outputs (time

The erection process of in situ cast concrete frameworks in multi-storey housing consists of multiple on site activities in which labour, equipment and materials are interacting in a complex system. Studies have shown that the current process involves a wide range of non-value adding activities, resulting in poor process efficiency. This paper presents a model developed for discrete-event simulati

In Sweden and elsewhere in the world the construction industry has encountered criticism due to its lower productivity gains in comparison to other industries. This is why continual improvement of processes and forms of cooperation are important, as is utilisation of technologies giving greater efficiencies. The focus in Sweden has mainly been on the construction of multifamily buildings, both bec

Ribonucleotide reductase (RNR) is a central enzyme for DNA building block synthesis. Most aerobic organisms, including nearly all eukaryotes, have class I RNRs consisting of R1 and R2 subunits. The catalytic R1 subunit contains an overall activity site that can allosterically turn the enzyme on or off by the binding of ATP or dATP, respectively. The mechanism behind the ability to turn the enzyme