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Increased cartilage turnover and circulating autoantibodies in different subsets before the clinical onset of rheumatoid arthritis.

BACKGROUND: /st> Previous studies have indicated that autoantibodies may be detected years before the clinical onset of rheumatoid arthritis (RA). Cartilage biomarkers, such as cartilage oligomeric matrix protein (COMP), have not been studied previously in samples collected before the diagnosis of RA. METHODS: /st> Between 1991 and 1996, 30 447 subjects were included in the Malmö Diet Cancer Study

Plus(s) at(t) i skandinaviska — en minimal matris.

The word plus(s) can function as a conjunction in Scandinavian, and as such coordinate for example embedded clauses introduced by the subjunction at(t). However, one can also find examples of clauses introduced by plus(s) at(t) although not preceded by another at(t)-clause. These constructions, which represent a relatively new development in Scandinavian, are semantically similar to coordinations

A 0.2V 0.44 uW 20 kHz Analog to Digital Sigma-Delta Modulator with 57 fJ/conversion FoM

This paper presents a 90 nm CMOS A/D modulator operating with a supply voltage of 0.2 V, well below the threshold voltage of the transistors. The modulator is an open-loop first-order architecture based on a frequency-modulated intermediate signal, generated in a ring voltage-controlled oscillator. The linearity of the modulator is greatly improved by the adoption of a so-called soft-rail in the o

Measurements of excited state lifetimes and oscillator strengths in Pt II

We report on radiative lifetime measurements of short-lived states in singly ionized platinum by excitation with pico-second laser pulses and subsequent time-resolved detection. The upper levels were populated from metastable ion levels in a laser-generated plasma using radiation in the UV/VUV spectral range. The following lifetimes were obtained: tau(5d(8)(F-3(4))6p(1/2), J = 7/2) = 3.9(3) ns, ta

TOTALL: high cost of allergic rhinitis-a national Swedish population-based questionnaire study.

Allergic rhinitis is a global illness with a well-recognised impact on quality of life and work performance. Comparatively little is known about the extent of its economic impact on society. The TOTALL study estimates the total cost of allergic rhinitis using a sample representing the entire Swedish population of working age. A questionnaire focused on allergic rhinitis was mailed out to a random

Low Serum Levels of Dehydroepiandrosterone Sulfate Predict All-Cause and Cardiovascular Mortality in Elderly Swedish Men.

Context: The age-related decline in dehydroepiandrosterone (DHEA) levels is thought to be of importance for general and vascular aging. However, data on the association between DHEA and mortality are conflicting. Objectives: We tested the hypothesis that low serum DHEA and DHEA sulfate (DHEA-S) levels predict all-cause and cardiovascular disease (CVD) death in elderly men. Design, Setting, and Par

Exploring the Duration of EU Imports

The objective of this paper is to perform an empirical description and analysis of the duration of EU imports from the rest of the world. Toward this aim, we employ a rich data set of detailed imports to individual EU15 countries from 140 non-EU exporters, covering the period 1962-2006. Using these data, we both perform a thorough descriptive analysis of the duration of EU trade, and test the data

Characterization of CA XV, a new GPI-anchored form of carbonic anhydrase.

The main function of CAs (carbonic anhydrases) is to participate in the regulation of acid-base balance. Although 12 active isoenzymes of this family had already been described, analyses of genomic databases suggested that there still exists another isoenzyme, CA XV. Sequence analyses were performed to identify those species that are likely to have an active form of this enzyme. Eight species had

Software Quality Alignment:Evaluation and Understanding

Abstract in UndeterminedBackground: The software development environment is growing increasingly complex, with a greater diversity of stakeholders involved in product development. Moves towards global software development with onshoring, offshoring, insourcing and outsourcing have seen a range of stakeholders introduced to the software development process, each with their own incentives and unders

On the complexity of resilient network design

In this article we prove NP-hardness of two well-known optimization problems related to the design of multicommodity flow networks with two different methods for providing network resiliency against failures: path diversity and flow restoration. Path diversity is a static mechanism that consists of using, for each demand, a number of paths and oversizing the flows assigned to these paths so that f