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Malignant cells, like all actively growing cells, must maintain their telomeres, but genetic mechanisms responsible for telomere maintenance in tumors have only recently been discovered. In particular, mutations of the telomere binding proteins alpha thalassemia/mental retardation syndrome X-linked (ATRX) or death-domain associated protein (DAXX) have been shown to underlie a telomere maintenance

Nebel D, Bratthall G, Ekblad E, Norderyd O, Nilsson B-O. Estrogen regulates DNA synthesis in human gingival epithelial cells displaying strong estrogen receptor β immunoreactivity. J Periodont Res 2011; doi: 10.1111/j.1600-0765.2011.01382.x. © 2011 John Wiley & Sons A/S Background and Objective: Estrogen acts via estrogen receptor (ER) α and β. The expression pattern of ERs and their importanc

The ability to anticipate future events and to modify erroneous anticipatory actions is crucial for the survival of any organism. Both theoretical and empirical lines of evidence implicate the cerebellum in this ability. It is often suggested that the cerebellum acquires "expectations" or "internal models." However, except in a metaphorical sense, the cerebellum, which consists of a set of interco

Plumage constitutes a significant component of the somatic investment of birds. A detailed investigation of feathers and moult can help to uncover trade-offs involved in somatic investment decisions, the sources of some of the costs birds have to pay and the potential fitness consequences. We used micro-computed tomography imaging to study the second moment of area, a structural parameter that is

A low-background inclusive search for new physics in events with same-sign dileptons is presented. The search uses proton-proton collisions corresponding to 20.3 fb(-1) of integrated luminosity taken in 2012 at a centre-of-mass energy of 8TeV with the ATLAS detector at the LHC. Pairs of isolated leptons with the same electric charge and large transverse momenta of the type e(+/-) e(+/-), e(+/-) mu

This article explores the different ways in which the nuclear catastrophe at the Chernobyl plant in 1986 is represented in selected films and novels produced and written since the fall of the Soviet Union in 1991. The most common way of imagining Chernobyl during this period is the apocalypse foreshadowing the collapse of the Soviet Union. However, it is also viewed as the catalyst for resurrectio

Blood is a tissue with high cellular turnover, and its production is a tightly orchestrated process that requires constant replenishment. All mature blood cells are generated from hematopoietic stem cells (HSCs), which are the self-renewing units that sustain life-long hematopoiesis. HSC behavior, such as self-renewal and quiescence, are regulated by a wide array of factors, including external sig

The mechanism by which incretins and their effect on insulin secretion increase markedly following gastric bypass surgery (GBP) is not fully elucidated. We hypothesized that a decrease in the activity of dipeptidyl peptidase-4 (DPP-4), the enzyme which inactivates incretins, may explain the rise in incretin levels post-GBP. Fasting plasma DPP-4 activity was measured after 10 kg equivalent weight l

BACKGROUND: LDL oxidation in the vascular wall is associated with aldehyde modification of surrounding extracellular matrix proteins that may target autoimmune responses against vascular tissues. Here we investigated the possible influence of immunity against a malondialdehyde (MDA)-modified form of the basement membrane protein laminin on atherosclerosis. METHODS AND RESULTS: IgM and IgG autoanti

An online survey in the form of a questionnaire was conducted to obtain the opinion of computer users with tetraplegia on their current computer interfaces and to assess desirable applications for future independent control using assistive devices. The survey included questions related to information about the respondents' injury/disease, everyday activities and social life, electronic devices and

Exercise intolerance is frequent among Fontan patients and an important determinant for quality of life. This study investigated the hemodynamic causes of impaired exercise capacity in Fontan patients with particular focus on the influence of stroke volume index (SVI) and heart rate (HR).

A novel environmentally sound continuous-flow hot water extraction and enzymatic hydrolysis method for determination of quercetin in onion raw materials was successfully constructed using a stepwise optimization approach. In the first step, enzymatic hydrolysis of quercetin-3,4'-diglucoside to quercetin was optimized using a three level central composite design considering temperature (75-95°C), p

Inflammation is a key factor in the development of plaque rupture and acute cardiovascular events. Although imaging techniques can be used to identify vulnerable atherosclerotic plaques, we are lacking non-invasive methods, such as plasma markers of plaque inflammation that could help to identify presence of vulnerable plaques. The aim of the present study was to investigate whether increased plas

For monotone systems evolving on the positive orthant, two types of Lyapunov functions are considered: Sum- and max-separable Lyapunov functions. One can be written as a sum, the other as a maximum of functions of scalar arguments. Several constructive existence results for both types are given. Notably, one construction provides a max-separable Lyapunov function that is defined at least on an arb

Laser-induced Rayleigh scattering is commonly employed for two-dimensional temperature measurements and offers benefits such as high accuracy, easily interpreted data and low experimental complexity. Yet the approach suffers from an interference often referred to as stray light, an umbrella term used for all spurious light being detected. As Rayleigh scattering is an elastic scattering phenomenon,

Proteoglycans consist of a protein core with one or more covalently attached glycosaminoglycan (GAG) side chains and have multiple roles in the initiation and progression of atherosclerosis. Here we discuss the potential and known functions of a group of small leucine-rich repeat proteoglycans (SLRPs) in atherosclerosis. We focus on five SLRPs, decorin, biglycan, lumican, fibromodulin and PRELP, b

The objective of this study was to compare the time from last suicide attempt to suicide in men and women with major depressive disorder with melancholic and/or psychotic features. The case records of 100 suicide victims with severe depression were evaluated. All suicide attempts during the course of depression were noted. The time from last suicide attempt to suicide was compared as well as the o

Abstract in Undetermined Fospeg® is a newly developed photosensitizer formulation based on meso-tetra(hydroxyphenyl)chlorin (mTHPC), with hydrophilic liposomes to carry the hydrophobic photosensitizer to the target tissue. In this study the pharmacokinetics and biodistribution of Fospeg® were investigated by high performance liquid chromatography at various times (0.5-18 hours) following systemic

The performance of teams, with different levels of domain and crisis management experience, managing unexpected and escalating situations was observed using a mid-fidelity ship-bridge simulation and analysed by applying the central concepts of joint activity coordination as well as Woods’s theory building on data overload. The coordination strategies used by the teams were evaluated by applying coo