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Methylating substances alter DNA by forming N3-methylthymidine (N3mT), a mutagenic base modification. To develop a sensitive analytical method for the detection of N3mT in DNA based on capillary electrophoresis with laser-induced fluorescence detection (CE-LIF), we synthesized the N3mT-3'-phosphate as a chemical standard. The limit of detection was 1.9 amol of N3mT, which corresponds to one molecu

A new sensitive analytical method using capillary electrophoresis with laser induced fluorescence (CE-LIF) was applied for the simultaneous detection of DNA methylation and hydroxymethylation levels in human cancers of different origin. DNA hydroxymethylation, measured as 5-hydroxymethylcytosine (5hmC) levels, was decreased in gliomas with mutation in the isocitrate dehydrogenase 1 (IDH1) gene whe

Purpose – The purpose of this paper is to further develop the conceptualization of music consumption in the digital age by examining how contemporary music listening is interweaved with other practices, how it shapes those practices and how it is in turn shaped by them.Design/methodology/approach – The paper draws on extensive, qualitative interviews with 15 Swedish music consumers. During the cou

Mosquitoes carry malaria and dengue fever and constitute a great threat to public health. We develop a wireless mosquito counting device which can provide valuable statistic information.

The preliminary remote laser-induced breakdown spectroscopy measurement of metals is performed on a mobile lidar system. The Nd:YAG laser synchronized with an ICCD spectrometer, the detection range can be achieved up to 45 m.

Otitis media is a common infectious disease in early childhood. We use an optical diagnostic system combining otoscopy and spectroscopy to improve the accuracy of diagnosis of otitis media.

We present further development and application examples of a thermometry approach capable of producing real-space temperature maps of operating nanoscale devices with sub-10nm resolution. The technique relies on scanning thermal microscopy with a resistive element coupled to a cantilevered tip. The resistive element acts both as integrated heater and as sensing element. A modulated temperature fie

Background Both internet-based cognitive-behavioural therapy (ICBT) and physical exercise are alternatives to treatment as usual (TAU) in managing mild to moderate depression in primary care.Aims To determine the cost-effectiveness of ICBT and physical exercise compared with TAU in primary care.Method Economic evaluation of a randomised controlled trial (N = 945) in Sweden. Costs were estimated by

PURPOSE: To estimate cause-specific mortality in osteoarthritis patients compared to the general population.METHODS: We identified all residents in southern Sweden aged 45-84 years in 2003. Through the Skåne Healthcare Register we identified those diagnosed with osteoarthritis in peripheral joints between 1998-2003. We followed all residents from 2004 until relocation outside of the region, death,

While there is a huge literature on exchange rate systems since the classical gold standard, less research has been devoted to comparisons of the different arguments that guided the choices. While the origin of the international gold standard in the 1870s was a result of silver coins disappearing from circulation due to rising silver prices, the gold standard has later been interpreted as a quest

Galectin-3 is a carbohydrate binding protein which has important roles in cancer and immunity. Potent galectin-3 inhibitors have been synthesized, for experimental purposes and potential clinical use. As galectin-3 is implicated in both intra- and extracellular activities, permeability of galectin-3 inhibitors is an important parameter determining biological effects. We compared the cellular uptak

Invasive extravillous cytotrophoblast of the human placenta expresses galectins-1, -3, and -8 in vivo and in vitro. This study aimed to investigate the potential role of galectin-3 in cell migration and invasion, using recombinant human galectin-3 (rhgalectin-3), small molecule galectin inhibitor I 47 , and galectin-3 silencing. HTR-8/SVneo cell migration was stimulated by rhgalectin-3 and reduce

Application of the Luttinger theorem to the Kondo lattice YbRh 2 Si 2 suggests that its large 4f-derived Fermi surface (FS) in the paramagnetic (PM) regime should be similar in shape and volume to that of the divalent local-moment antiferromagnet (AFM) EuRh 2 Si 2 in its PM regime. Here we show by angle-resolved photoemission spectroscopy that paramagnetic EuRh 2 Si 2 has a large FS essenti

There is a growing evidence of the protective role of the Mediterranean diet (MD) on cancer. However, no prospective study has yet investigated its influence on lymphoma. We evaluated the association between adherence to the MD and risk of lymphoma and its subtypes in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The analysis included 476,160 participants, recruite

The present paper investigates the fluid flow and heat transfer behaviors of jet impingement in cross-flow modified by a vortex generator pair (VGP). The velocity of the jet is kept at 12 m/s and that of the cross-flow is varied between 5 m/s and 8 m/s. The spacing between the jet and target surface is 4 times the jet diameter. Particle Image Velocimetry (PIV) and Liquid Crystal Thermography (LCT)

Phased array antennas are cornerstones in many proposed antenna solutions concerning the next generation of both airborne radar systems and wireless communication systems (5G). Additionally, millimeter wave (mm-wave) frequencies are expected to play an integral role in 5G, and are deemed well-suited for inspecting structural components used in the aerospace industry.This dissertation consists of a

The effect of sub-monolayer silicon on the oxidation of Al(111) and Al(100) surfaces was investigated using X-ray Photoelectron Spectroscopy (XPS) and density functional theory (DFT) calculations. On both surfaces the adatom site is preferred over substituting Si into the Al-lattice; on Al(100) the four fold hollow site is vastly favored whereas on Al(111) bridge and hollow sites are almost equal