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The outermost layer of the skin, the stratum corneum (SC), is a lipid-protein membrane that experiences considerable osmotic stress from a dry and cold climate. The natural moisturizing factor (NMF) comprises small and polar substances, which like osmolytes can protect living systems from osmotic stress. NMF is commonly claimed to increase the water content in the SC and thereby protect the skin f
Using inelastic proton-proton interactions at root s = 900 GeV and 7 TeV, recorded by the ATLAS detector at the LHC, measurements have been made of the correlations between forward and backward charged-particle multiplicities and, for the first time, between forward and backward charged-particle summed transverse momentum. In addition, jet-like structure in the events is studied by means of azimut
Frequency-modulated light scattering interferometry, which employs a frequency-modulated coherent light source and examines the intensity fluctuation of the resulting scattered light using a heterodyne detection scheme, was utilized to evaluate the optical properties of liquid phantoms made of Intralipid(R) and Indian ink. Based on the diffusion theory, nonlinear fits to the power spectrum of the
In this work, we focus on the computational bridging between the meso- and macro-scale in the context of the hybrid modelling of Internal Traverse Grinding with electro-plated cBN wheels. This grinding process satisfies the manufacturing industry demands for a high rate of material removal along with a high surface quality while minimising the number of manufacturing processes invoked. To overcome
Platelets are rapidly responsive sentinel cells that patrol the bloodstream and contribute to the host response to infection. Platelets have been reported to form heterotypic aggregates with leukocytes and may modulate their function. Herein we have investigated platelet-neutrophil complex formation and neutrophil function in response to distinct agonists. The endogenous platelet activator thrombi
Heat stress at the workplace is an occupational health hazard that reduces labour productivity(1). Assessment of productivity loss resulting from climate change has so far been based on physiological models of heat exposure(1). These models suggest productivity may decrease by 11-27% by 2080 in hot regions such as Asia and the Caribbean(2), and globally by up to 20% in hot months by 2050(3). Using
Human fibrocytes are bone marrow-derived mesenchymal progenitor cells that express a variety of markers related to leukocytes, hematopoietic stem cells and a diverse set of fibroblast phenotypes. Fibrocytes can be recruited from the circulation to the tissue where they further can differentiate and proliferate into various mesenchymal cell types depending on the tissue niche. This local tissue nic
Introduction: A significant proportion of high-risk breast cancer families are not explained by mutations in known genes. Recent genome-wide searches (GWS) have not revealed any single major locus reminiscent of BRCA1 and BRCA2, indicating that still unidentified genes may explain relatively few families each or interact in a way obscure to linkage analyses. This has drawn attention to possible be
Let P be a set of n points in the Euclidean plane and let O be the origin point in the plane. In the k-tour cover problem (called frequently the capacitated vehicle routing problem), the goal is to minimize the total length of tours that cover all points in P, such that each tour starts and ends in O and covers at most k points from P. The k-tour cover problem is known to be NP-hard. It is also kn
In this study, we examine individual patent holders and the fate of their inventions. A unique database consisting of over 800 private individuals who have obtained decision rights over a new technology in Sweden is used to analyse how opportunity and individual level characteristics are related to the likelihood that patented inventions are commercialised in a new or existing small firm. Our find
To determine benefits and harms of arthroscopic knee surgery involving partial meniscectomy, debridement, or both for middle aged or older patients with knee pain and degenerative knee disease.
Recent developments in the application of x-ray micro-tomography in laboratory geomechanics have allowed all the individual grains of sand in a test sample to be seen and identified uniquely in 3D. Combining such imaging capabilities with experiments carried out ‘‘in situ’’ within an imaging set-up has led to the possibility of directly observing the mechanisms of deformation as they happen. The c
The transverse momentum (p(T)) dependence of the nuclear modification factor R-AA and the centrality dependence of the average transverse momentum
To investigate whether apoM is excreted in urine of children undergoing heart surgery and the potential of apoM as early biomarker of acute kidney injury (AKI).
Background: High plasma copeptin (copeptin), the C-terminal fragment of arginine vasopressin pro-hormone, has been associated with the metabolic syndrome (MetS), diabetes mellitus (DM) development and nephropathy. Here we tested whether elevated copeptin level is associated with later development of the MetS, its individual components and microalbuminuria. Methods: We analysed copeptin at baselin
We analyze a model for the Higgs sector with two scalar doublets and a Z(2) symmetry that is manifest in the Yukawa sector but broken in the potential. Thus, one of the doublets breaks the electroweak symmetry and has tree-level Yukawa couplings to fermions, whereas the other doublet has no vacuum expectation value and no tree-level couplings to fermions. Since the Z(2) parity is broken the two do
For the first time in serveral years, the El Nino-Southern Oscillation did not dominate regional climate conditions around the globe. A weak La Ni a dissipated to ENSOneutral conditions by spring, and while El Nino appeared to be emerging during summer, this phase never fully developed as sea surface temperatures in the eastern conditions. Nevertheless, other large-scale climate patterns and extre
