Galectins are a 15-member family of β-D-galactose binding proteins that are interesting targets in drug development, since they are linked to various inflammatory diseases, fibrosis and cancer. Efforts to find galactose derived high-affinity inhibitors that are selective towards members of the galectin-family have increased in the last decade. On top of that Galectin-3 has been shown to be a suita

The results of studies have shown that the several applications such as microbial electrochemical system (MES), bio-electrochemical systems (BESs) and production of beneficial chemicals are due to electrochemical connection among electrodes and microorganisms. The following two factors are important in choosing the microbe mediated electrochemical biosensors: I) Binding of bacterial cells on the e

Emerging technologies have the potential to bring numerous new opportunities and solutions to the existing challenges, including addressing sustainable development goals (SDGs). Particular hopes are given to areas of the life that require our urgent action, these include but are not limited to medicine and food security. Scientists investigate how these technological advances can be applied for th

Electrical power distribution is currently seeing both challenges and opportunities. On one hand, the digitisation of measurement data and modern measurement devices enable deeper analysis and planning of the grid. On the other hand, the expansion of privately owned photovoltaic systems and the customers' desire to produce their own electricity is an inevitable challenge that distribution comp

This study attempts to assess and correct the performance of Integrated Multi-satellite Retrievals for Global Precipitation Measurement (GPM-IMERG) final run daily precipitation product across Sweden. The performance of GPM-IMERG version 6 final run was evaluated against 677 rain gauges in a period from 12 March 2014 to 31 May 2019. Continuous and categorical performance measures were used to char

Visste du att många läkemedel tillverkas av genmodifierade bakterier? Också ofta i genmodifierade celler från däggdjur, till exempel från kinesiska hamstrars äggstockar. Läkemedel producerade i celler är de snabbast växande på marknaden, och kan till exempel användas för att producera insulin eller ett COVID-19 vaccin. I denna studie har en ny metod utvecklats för att säkerställa att sådana läkemeHost cell protein (HCP) is quantified in the purification steps of biopharmaceutical production and is part of ensuring the purity of the final drug product. The gold standard method for HCP quantification is enzyme-linked immunosorbent assay (ELISA), but a new approach is proposed here with fully customized bio-layer interferometry assays for yeast and chinese hamster ovary (CHO) cells. The new

Density based topology optimization has become an efficient way to design optimal complex structures with different goals, constraints and boundary conditions. To regularize the solution, density filters are utilized and is controlled by the length scale. The length scale controls minimum feature sizes, as well as minimum curvatures in the structure. Usually a constant length scale is used through

Background/Problematization: Iconic brands are the gold standard of branding and have established a central role in the consumers’ lives. Behind every iconic brand, we can find iconic products. Despite the importance of these products, iconic products are overlooked in academia. Few studies have explored the concept and there is no common definition or comprehensive framework. This is restrictive

In a phase of instability during the dynamical evolution of some multiple exoplanetary systems, exchange of angular momentum and/or energy through gravitational interactions between planets will lead to alterations of their orbital properties. In some cases, planetary orbits end up crossing, which leads to close encounters between two planets. In turn, they undergo a planet--planet scattering even

Bluetooth is a short-range technology, it helps with wireless communication between many electronic devices. Bluetooth low energy (BLE) is the advanced version of Bluetooth which uses low energy compared to the standard Bluetooth. Bluetooth mesh technology play a crucial role in the Internet of things (IoT). The IoT mesh technology enables many-to-many and one-to-many communication. This project d

Oat starch, like starch from other plants, is composed of amylose and amylopectin. The arrangement and abundance of these polysaccharides offers distinct properties to the formed starch. Starch with an elevated amount of amylose is of commercial interest and amount of amylose present in oats differs within cultivars. In this study, a mutant oat population developed by CropTailor was screened usin

The study considers the phenomenon of double alienation, by which is meant the immigrant’s feeling of in a sense being alienated in their native country as well as in the new one. Those elements of their behaviour which are common in the one country or the other are expected there, whereas those which are not are seen as strange and different. This gives the immigrant a feeling of being at home in

Vi lever idag i en värld vars system och strukturer tillåter oss människor att konsumera och producera långt över våra tillgångar. Om inga åtgärder görs riskerar vi oåterkalleliga förändringar i klimat och miljö som kommer att påverka förutsättningarna för kommande generationer. Klimatkrisen är global men vi måste agera lokalt. Nu. Hur vi utformar byggnader och samhällen har stor inverkan på milj

The West Bank attracts countless researchers due to the conflict’s intractable label. On one hand, these researchers are drawn to the Palestinian-Israeli conflict due to logistical reasons: accessibility to the area, academic prestige, ample funding, grant and networking opportunities. On the other, researchers are allured due to an Orientalist fascination with conducting fieldwork in the West Ban

Utarmningen av resurser är ett växande problem som har påskyndat behovet att förändra våra konsumtionsmönster. Gamla, linjära modeller för produktion måste ersättas av nya tillvägagångssätt som minskar mängden avfall och maximerar värdet genom hela produktens livscykel. Denna strategi förkroppsligas av den Cirkulära Ekonomin (CE). En viktig del av CE är återbruk, det vill säga att gamla produkter The growing threat of resource depletion has spurred on the need to change how we consume. Old, linear modes of production must be replaced by an approach that reduces waste and maximizes value throughout the product’s entire life cycle. This strategy is embodied by the Circular Economy (CE). A key aspect of CE is reuse, referring to the repurposing of old products to avoid generating waste and de

n this master’s thesis, one studies the liquidity of bonds. One considers bid-ask spread and develops four estimators of this liquidity measure based on trading data. One also computes Amihud’s measure. This approach helps to determine liquidity and its associ-ated costs without quotation. One finds out that the Roll, the FHT estimators and the Amihud measure take the lead. One looks at the changes

The aim of this thesis is to describe and explain how meal-box, as a digital device designed to assist households in carrying out eating practices, reconfigure household practices and enable specific behavioural activities, including sustainability. Taking a socio-material and practice theory approach and drawing on an ethnographic study of three meal-box providers – The Seasons, Hello Fresh and L

Studier har visat att det kan göras bra bedömningar av trafiksäkerhetstillstånd och dess bidragande faktorer genom att studera konflikterna i trafiken istället för olyckorna. Genom att undersöka hur konflikterna i en trafikplats ser ut kan man få mer data och få den mycket snabbare än om man undersöker olycksdata. Genom att använda nya verktyg till datorer som djupinlärning kan man även lättare taStudies have shown that good assessments can be made of traffic safety conditions and contributing factors by studying the conflicts in traffic rather than the accidents. By analysing the conflicts in a location with traffic you can get more data and in a shorter time-frame than if analysing accident data. By using new tools for computers such as deep learning, it's easier to get these conflic