Synthetic Route towards macrocyclic Galectin-3 Inhibitors
Galectins are a 15-member family of β-D-galactose binding proteins that are interesting targets in drug development, since they are linked to various inflammatory diseases, fibrosis and cancer. Efforts to find galactose derived high-affinity inhibitors that are selective towards members of the galectin-family have increased in the last decade. On top of that Galectin-3 has been shown to be a suita