Both the East Asian winter monsoon (EAWM) and El Niño (EN) activities are vital climate modes that regulate the Pacific hydrologic cycle. However, the Holocene interactions among the EAWM, EN activities, and tropical Pacific precipitation remain unclear due to the lack of appropriate EAWM proxies. Here, we present high-resolution grain size records from the East China Sea shelf along with a transi

Bis(phosphinidene)-capped triiron carbonyl clusters, including electron rich derivatives formed by substitution with chelating diphosphines, have been prepared and examined as proton reduction catalysts. Treatment of the known cluster [Fe3(CO)9(µ3-PPh)2] (1) with various diphosphines in refluxing THF (for 5, refluxing toluene) afforded the new clusters [Fe3(CO)7(µ3-PPh)2(κ2-dppb)] (2), [Fe3(CO)7(µ

Large-scale radiation emergency scenarios involving protracted low dose rate radiation exposure (e.g. a hidden radioactive source in a train) necessitate the development of high throughput methods for providing rapid individual dose estimates. During the RENEB (Running the European Network of Biodosimetry) 2019 exercise, four EDTA-blood samples were exposed to an Iridium-192 source (1.36 TBq, Tech

This document is a position statement from the Society for Cardiovascular Magnetic Resonance (SCMR) on recommendations for clinical utilization of cardiovascular magnetic resonance (CMR) in women with cardiovascular disease. The document was prepared by the SCMR Consensus Group on CMR Imaging for Female Patients with Cardiovascular Disease and endorsed by the SCMR Publications Committee and SCMR E

Thin, stable and inert dielectric spacers are essential for manufacturing electronic devices based on 2D materials. However, direct synthesis on top of 2D materials is difficult due to their inert nature. In this work, we studied how an electron beam induces fragmentation of borazine and enables spatially confined synthesis of amorphous-BNx on graphene at room temperature. Using a combination of X

Extracellular vesicles can mediate cell-to-cell communication, or relieve the parent cell of harmful substances, in order to maintain cellular integrity. The content of extracellular vesicles includes miRNAs, mRNAs, growth factors, complement factors, cytokines, chemokines and receptors. These may contribute to inflammatory and infectious diseases by the exposure or transfer of potent effectors th

Diffusion MRI uses magnetic field gradients to sensitize the signal to the random motion of spins. In addition to the prescribed gradient waveforms, background field gradients contribute to the diffusion weighting and thereby cause an error in the measured signal and consequent parameterization. The most prominent contribution to the error comes from so-called ‘cross-terms.’ In this work we presen

ABSTRACT: In this observational study, by the use of a multiplex proteomic platform, we aimed to explore associations between 92 targeted proteins involved in cardiovascular disease and/or inflammation, and phenotypes of deteriorating vascular health, with regards to ethnicity.Proteomic profiling (92 proteins) was carried out in 362 participants from the Sympathetic activity and Ambulatory Blood P

Importance Tracheal intubation is one of the most commonly performed and high-risk interventions in critically ill patients. Limited information is available on adverse peri-intubation events.Objective To evaluate the incidence and nature of adverse peri-intubation events and to assess current practice of intubation in critically ill patients.Design, Setting, and Participants The International Obs

‘… technical law by itself is useless, at best an arid game played by keen minds in courtrooms and academic ivory towers. To understand its significance we must look at its historical and social setting'. (K. W. Wedderburn, The Worker and the Law 7 (Penguin Books 1965)). ‘… ultimately the point of labour law is to do something'. (Hugh Collins, Gillian Lester & Virginia Mantouvalou, Introductio

Glycobiology is dogged by the relative scarcity of synthetic, defined oligosaccharides. Enzyme-catalysed glycosylation using glycoside hydrolases is feasible but is hampered by the innate hydrolytic activity of these enzymes. Protein engineering is useful to remedy this, but it usually requires prior structural knowledge of the target enzyme, and/or relies on extensive, time-consuming screening an

I denna mikrostudie analyseras en brottslings väg från barndom till livstids straffånge i det tidiga 1800-talets svenska samhälle. Undersökningen vilar på domböcker och fängelseprotokoll i kombination med en personlig biografi i ett försök att rekonstruera och förstå brottslingens möjligheter samt vilka handlingar och vägval som till den slutliga livstidsdomen.

Streptococcus pneumoniae (pneumococcus) resides asymptomatically in the nasopharynx but can progress from benign colonizer to lethal pulmonary or systemic pathogen. Both viral infection and aging are risk factors for serious pneumococcal infections. Previous work established a murine model that featured the movement of pneumococcus from the nasopharynx to the lung upon nasopharyngeal inoculation w

Functionally graded additive manufacturing (FGAM) is a layer-by-layer manufacturing technique that allows material composition and organization to be achieved within a single volume to enable variational functionalities. Unlike traditional production methods, FGAM can produce freeform structures with customizable, site-specific properties at strategic locations. Advanced additive manufacturing pro

The ex vivo large animal retina is extensively used in research ranging from discovery of disease mechanisms to future treatment paradigms. Due to limited standardization when harvesting the tissue, the time after enucleation is often ex- tended for several hours, a factor that so far has not yet been fully characterized. The purpose of this study was to investi- gate the relationship between time