Objective: To characterize the trend of opioid use (number of users, dispensations and oral morphine milligram equivalents) in Catalonia (Spain). Design, setting, and participants: This population-based cohort study included all individuals aged 18 years or older, registered in the Information System for Research in Primary Care (SIDIAP), which covers >75% of the population in Catalonia, Spain, fr

We report, the use of laser-plasma-driven x rays to reveal the three-dimensional (3D) structure of a highly atomizing water spray. Soft x rays approximately 5 keV are generated by means of a laser-plasma accelerator. Transmission radiography measurements are performed at different angles, by rotating a multihole injector. Using computer tomography, the local liquid volume distribution and its spat

Objective: During androgen ablation in prostate cancer by the standard gonadotropin-releasing hormone (GnRH) agonist treatment, only luteinizing hormone (LH) is permanently suppressed while circulating follicle-stimulating hormone (FSH) rebounds. We explored direct prostatic effects of add-back FSH, after androgen ablation with GnRH antagonist, permanently suppressing both gonadotropins. Methods:

OBJECTIVE: Biomarkers predicting risk of type 1 diabetes (stage 3) among children with islet autoantibodies are greatly needed to prevent diabetic ketoacidosis and facilitate prevention therapies.RESEARCH DESIGN AND METHODS: Children in the prospective The Environmental Determinants of Diabetes in the Young (TEDDY) study (n = 707) with confirmed diabetes-associated autoantibodies (GAD antibody, IA

The historical subclassification of diabetes into predominantly types 1 and 2 is well appreciated to inadequately capture the heterogeneity seen in patient presentations, disease course, response to therapy and disease complications. This review summarises proposed data-driven approaches to further refine diabetes subtypes using clinical phenotypes and/or genetic information. We highlight the bene

A new combination, Nephromopsis annae (Oxner) A.Thell & Divakar is proposed and the basionym Cetrariasubalpina Imshaug is preferred over the combination in Nephromopsis.

The COVID-19 pandemic, climate crisis, and a shifting geopolitical landscape present us with strategic, ethical and planetary dilemmas that demand more reflective action on behalf of actors at every level. The identified challenges of the not-so-distant future require a fundamental transformation of how companies do business, and the role of business schools in shaping the business practices of th