During nutrient limitation, bacteria produce the alarmones (p)ppGpp as effectors of a stress signaling network termed the stringent response. RsgA, RbgA, Era, and HflX are four ribosome-associated GTPases (RA-GTPases) that bind to (p)ppGpp in Staphylococcus aureus. These enzymes are cofactors in ribosome assembly, where they cycle between the ON (GTP-bound) and OFF (GDP-bound) ribosome-associated

Rapid Diagnostic Tests (RDTs) for malaria are restricted to a few biomarkers and antibody-mediated detection. However, the expression of commonly used biomarkers varies geographically and the sensibility of immunodetection can be affected by batch-to-batch differences or limited thermal stability. In this study we aimed to overcome these limitations by identifying a potential biomarker and by deve

The effect of freestream turbulence on the flow past a circular cylinder (tube) was studied experimentally for Reynolds numbers between 2 x 104 and 6 x 104. Investigations were carried out for uniform (non-turbulent) flow and for turbulent flows having turbulence intensities between 1.3 and 4.1%. The variations in the pressure forces and shedding frequencies were found to be related to the variati

The fast growth of e-commerce and omni/multi-channel retailing brings new challenges for efficient inventory management. One such challenge concerns service differentiation across channels when upstream central warehouses satisfy both direct customer demand and replenishment orders from downstream retailers. Motivated by industry collaboration, we address this issue by developing a combined stock

We report a novel approach for single-shot planar imaging of CH3 radicals in premixed methane and air flames. A 213 nm beam from the 5th harmonic of an Nd:YAG laser was resonantly absorbed by the CH3 radicals, which were excited to the highly pre-dissociative upper level and dissociated to H2 and CH (X), as the main dissociation channel. The CH radicals were consequently excited by a 388 nm beam f

INTRODUCTION: Collagenous colitis (CC) is a common cause of chronic diarrhea and is characterized by a subepithelial thickened collagen layer in the colonic mucosa. It shares many of the characteristics found in autoimmune diseases, but no autoantibodies have been identified. In CC, an imbalance in collagen turnover is evident. The purpose of the present study was to investigate whether any collag

During March 2020 a large-span arena, Tarfalahallen, collapsed. The main load-bearing girders with a 54 m span were high and slender glulam trussed beams, supported from below by a cable system via vertical struts. Investigations concluded that the failure was initiated by out-of-plane buckling of the struts and slender beam, in spite of lateral stabilization by steel roof sheeting at the top edge

Background: [18F]PSMA-1007 is a promising tracer for integrated positron emission tomography and computed tomography (PET/CT). Objective: Our aim was to assess the diagnostic accuracy of [18F]PSMA-1007 PET/CT for primary staging of lymph node metastasis before robotic-assisted laparoscopy (RALP) with extended lymph node dissection (ePLND). Design, Setting and Participants: The study was a retrospe

Public and private policies typically consider the construction of infrastructure the most appropriate response to the problems of water scarcity and water disputes. However, infrastructure in itself not always is the solution. In this context we have the following questions: What are the logics behind the construction and implementation of water infrastructure? Why water infrastructures are not a

The phenomena of landgrabbing and monopolizing of water sources have gained increasing attention in recent years. Nevertheless, very few studies have dealt with the problem of the grabbing and concentration of resources from an ethnographic perspective that would make it possible to illustrate the different ways in which dispossession takes place, as well as its concrete mechanisms and effects in

Purpose of Review: Producing wood of the right quality is an important part of forest management. In the same way that forest growth models are valuable decision support tools for producing desired yields, models that predict wood quality in standing trees should assist forest managers to make quality-influenced decisions. A challenge for wood quality (WQ) models is to predict the properties of po

Universities are powerful drivers to create and advance knowledge on sustainable development. Furthermore, they can be used as a controlled environment to apply innovative technologies and approaches. This process also embraces industry and government, in the triple helix innovation model, as in the University of Campinas (Unicamp), Brazil—one of the best Latin American universities (3rd)—and imme

Purpose: A major challenge in osteoporosis is to identify individuals at high fracture risk. We investigated six bone turnover markers (BTMs) to determine association with specific fracture types; the time-frame for risk prediction and whether these are influenced by age at assessment. Methods: Population-based OPRA cohort (n = 1044) was assessed at ages 75, 80, 85 and fractures documented for up

Obesity constitutes a major global health threat and is associated with a variety of diseases ranging from metabolic and cardiovascular disease, cancer to neurodegeneration. The hallmarks of neurodegeneration include oxidative stress, proteasome impairment, mitochondrial dysfunction and accumulation of abnormal protein aggregates as well as metabolic alterations. As an example, in post-mortem brai

Currently, there is a need for diagnostic markers in Lewy body disorders (LBD). α-synuclein (αSyn) RT-QuIC has emerged as a promising assay to detect misfolded αSyn in clinically or neuropathologically established patients with various synucleinopathies. In this study, αSyn RT-QuIC was used to analyze lumbar CSF in a clinical cohort from the Swedish BioFINDER study and postmortem ventricular CSF i

BACKGROUND: Coarctation of the aorta coexists with other cardiac anomalies and has long-term complications, including recoarctation, which may require intervention after the primary coarctation repair. This study aims to clarify the prevalence of and risk factors for interventions related to the coarctation complex as well as late mortality in a large contemporary patient population. METHODS AND R

The prediction of species geographic redistribution under climate change (i.e. range shifts) has been addressed by both experimental and modelling approaches and can be used to inform efficient policy measures on the functioning and services of future ecosystems. Dynamic global vegetation models (DGVMs) are considered state-of-the art tools to understand and quantify the spatio-temporal dynamics o