Purpose – This chapter presents a framework for an action research based intervention to develop and transform sustainable healthcare in a regional context. The framework is illustrated by the case of the Regional Cancer Centre (RCC) West in western Sweden. Design/methodology/approach – The framework draws upon and develops Pettigrew’s context-content-process model of strategic change and applies

Pulmonary infection is a major cause of mortality and morbidity, and the magnitude of the lung inflammatory response correlates with patient survival. Previously, we have shown that neutrophil migration into joints is regulated by arthritis severity quantitative trait loci (QTLs). However, it is unclear whether these QTLs contribute to the regulation of lung inflammation in pneumonias. Therefore,

Objective:: The loss of a parent to cancer is considered one of the most traumatic events a teenager can experience. Studies have shown that teenagers, from the time of diagnosis, are already extremely worried about the consequences of a parent's cancer but tend to be left to manage these concerns on their own. The present study aimed to explore young adults' advice to healthcare professionals on

Huntington’s disease (HD) is caused by a CAG trinucleotide repeat expansion in the huntingtin (HTT) gene. HD is an inherited progressive neurodegenerative disorder manifested by the wide array of motor dysfunctions, as well as non-motor symptoms. The latter include metabolic dysfunction and psychiatric deficits, such as depression and anxiety, are often observed in patients andanimal models of HD

The thesis explores the obligation in international law to protect the ecological integrity of transboundary watercourses. The thesis specifically examines the obligation to protect environmental flows, which essentially means to protect a certain water flow for the benefit of freshwater ecosystems and the ecosystem services they supply. The obligation to protect the integrity of transboundary watThe thesis explores the obligation in international law to protect the ecological integrity of transboundary watercourses. The thesis specifically examines the obligation to protect environmental flows, which essentially means to protect a certain water flow for the benefit of freshwater ecosystems and the ecosystem services they supply. The obligation to protect the integrity of transboundary wat

Objective: To investigate the influence of cardiovascular risk factors, including fasting plasma glucose (FPG), on the association between electrocardiographic (ECG) and echocardiographic left ventricular hypertrophy (LVH) in an elderly population. Methods: We tested cross-sectional associations between electrocardiographic and echocardiographic LVH, defining LVH according to the Sokolow-Lyon volt

High mesoporous carbon aerogels (CA) were prepared by a sol-gel method, followed by supercritical drying with liquid CO2 and pyrolysis under inert atmosphere. The morphological and structural characteristics (surface area, pore size distribution and pore volume) of CA were examined by using N2 adsorption/desorption isotherms, TEM, SEM and AFM measurements. CA, dispersed in a chitosan (Chi) solutio

Genomes of prokaryotes differ significantly in size and DNA composition. Escherichia coli is considered a model organism to analyze the processes involved in bacterial genome evolution, as the species comprises numerous pathogenic and commensal variants. Pathogenic and nonpathogenic E. coli strains differ in the presence and absence of additional DNA elements contributing to specific virulence tra

This study quantitatively diagnose the linkage between Total Solar Irradiance (TSI) and Earth's near-surface air temperature (TAS) of past 1000-year as simulated by Paleoclimate Modeling Intercomparison Project 3 (PMIP3) models. The results demonstrate that there is causal feedback of TAS from TSI variations, especially in the tropical and subtropical regions. The consistency between models in sim

INTRODUCTION: Sepsis is characterized by dysregulated systemic inflammation and cytokine storm. Angiopoietin-2 (Ang-2) is known to closely correlate with severity of sepsis-related acute lung injury and mortality. The aim of this study was to clarify the mechanisms involved in Ang-2 secretion to better understand the pathophysiology of sepsis.MATERIALS AND METHODS: The concentration of Ang-2 was a

Background: Forensic psychiatric patients present a challenge as they manifest severe mental disorders together with criminal behaviour. There are well-known risk factors for criminal behaviour in the general population, yet knowledge of what predicts reconviction in the Swedish forensic population in the long-term perspective is still insufficient. Aims: The study aims to (1) describe background

Mitonuclear discordance across taxa is increasingly recognized as posing a major challenge to species delimitation based on DNA sequence data. Integrative taxonomy has been proposed as a promising framework to help address this problem. However, we still lack compelling empirical evidence scrutinizing the efficacy of integrative taxonomy in relation to, for instance, complex introgression scenario

This article discusses the enigmatic logion 27 in the Gospel of Thomas. It argues that preconceived notions of the text being “Gnostic” have affected previous interpreta- tions of how the Sabbath is portrayed in logion 27. A discussion follows concerning the many different interpretations of the elusive second part of the logion and the phrase σαββατίσητε τὸ σάββατον/ⲉⲓⲣⲉ ⲙ̄ⲡⲥⲁⲙⲃⲁⲧⲟⲛ ⲛ̄ⲥⲁⲃⲃⲁⲧⲟⲛ. T

Bacillus subtilis is an endospore-forming bacterium. There are indications that protein disulfide linkages occur in spores, but the role of thiol-disulfide chemistry in spore synthesis is not understood. Thiol-disulfide oxidoreductases catalyze formation or breakage of disulfide bonds in proteins. CcdA is the only B. subtilis thiol-disulfide oxidoreductase that has previously been shown to play so

An experimental investigation has been carried out to find the flow and the pressure difference across the port to channel in plate heat exchangers for a wide range of Reynolds number. 1000-17000. In the present study, low corrugation angle plates have been used for different number of channels, namely, 20 and 80. Water has been used as working fluid for both hot and cold fluids. The pressure prob

ABA triblock copolymers having benzimidazole-tethered end blocks have been prepared and characterized with respect to their intrinsically proton conducting properties. The copolymers were synthesized by using a linear poly(ethylene oxide) (PEO) as a difunctional macroinitiator for the anionic ring-opening polymerization of allyl glycidyl ether. The pendent allyl groups of the end blocks were subse

Case study is a suitable research methodology for software engineering research since it studies contemporary phenomena in its natural context. However, the understanding of what constitutes a case study varies, and hence the quality of the resulting studies. This paper aims at providing an introduction to case study methodology and guidelines for researchers conducting case studies and readers st