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Intestinal metaplasia at the gastroesophageal junction is associated with gastroesophageal reflux but not with Helicobacter pylori infection

Objective: Studies of the etiology of intestinal metaplasia (IM) at a normal appearing gastroesophageal junction (GEJ) are conflicting as associations with both H. Pylori (HP) infection and gastroesophageal reflux has been reported. The aim of this study was to investigate whether IM at the GEJ is associated with gastroesophageal reflux or HP infection. Material and methods: Fifty asymptomatic vol

A framework for aggregating risk information across organisational levels—the case of Swedish municipalities

Performing risk assessments for hierarchical, multi-functional systems, such as a municipality, is an activity that requires input from a multitude of actors. In such systems risk assessments can be performed at many system levels and support different types of decisions. For issues that are constrained to a specific sub-system, such as a municipal department, decisions can be preferably taken at

Theoretical shear strength and the onset of plasticity in nanodeformation of cubic boron nitride

The nanoindentation in the continuous stiffness measurement mode was used to investigate the onset of plasticity at the nanodeformation of cubic boron nitride (cBN). This technique allows us to reveal an elastic-plastic transition in the contact and to measure the yield strength of cBN at the nanoscale. An abrupt elastoplastic transition (a pop-in) was observed in the (111) cBN single crystal as a

Gambling disorder, increased mortality, suicidality, and associated comorbidity : A longitudinal nationwide register study

BACKGROUND AND AIMS: Gambling disorder (GD) appears to be an independent risk factor for suicide, and all-cause mortality has been sparsely studied in patients with GD. This study aims to explore mortality and suicide rates in individuals with GD compared to the general population as well as explore risk factors associated with all-cause mortality and suicide mortality. METHODS: This is a nationwi

Constructing a typology of virtual city brand co-creation practices: an ecological approach

PurposeThe paper aims to offer an approach that allows an analysis and construction of a typology of virtual city brand co-creation practices.Design/methodology/approachThe approach is illustrated by using data collected in regard to the branding of Stockholm; it is based on visual representations expressing the process in which brand co-creation unfolds in a network of different affective modalit

Scrap happens : A case of industrial end-users, maintenance and component remanufacturing outcome

Extended product life and reuse are cornerstones of the circular economy vision. Remanufacturing is one strategy that could be used to facilitate more reuse. Research on remanufacturing often addresses the use phase of a product from the perspective of the remanufacturer, not of the end-user of the product. Results are often described in terms of barriers and drivers, with end-user awareness of an

Prospective associations between cardiac stress, glucose dysregulation and executive cognitive function in Black men : The Sympathetic activity and Ambulatory Blood Pressure in Africans study

Objective: Glucose dysregulation is an independent risk factor for cardiovascular and neurodegenerative disease development through synaptic dysfunction resulting in cognitive decline. The aim of this study was to study the interplay between impaired glycaemic metabolism (hyperglycaemia and insulin resistance), cardiac stress (cardiac troponin T and N-terminal brain natriuretic peptide) and execut

The Uses of Justice in Global Perspective, 1600-1900

The Uses of Justice in Global Perspective, 1600–1900 presents a new perspective on the uses of justice between 1600 and 1900 and confronts prevailing Eurocentric historiography in its examination of how people of this period made use of the law.Between 1600 and 1900 the towns in Western Europe, the Kingdoms in Eastern Europe, the Empires in Asia and the Colonial States in Asia and the Americas wer

Cancer chromosome breakpoints cluster in gene-rich genomic regions

Cancer cells are characterized by chromosome abnormalities, of which some, in particular balanced rearrangements, are associated with distinct tumor entities and/or with specific gene rearrangements that represent important steps in the carcinogenic process. However, the vast majority of cytogenetically detectable structural aberrations in cancer cells have not been characterized at the nucleotide

Methods to Detect Loss of Lysosomal Membrane Integrity

Loss of lysosomal membrane integrity, often referred to as lysosomal membrane permeabilization (LMP), occurs in many instances of cell death either as an initiating or as an amplifying event. Currently, the best method for detecting LMP is the galectin puncta formation assay which can be used for a broad range of sample types, both fixed and live, is easy to perform, and highly sensitive. This met

The practice of targeting visitors to urban destinations – a critical discussion of DMOs information strategies

How do you attract visitors to your city? How do you manage to be visible in the information flow for potential visitors? Urban Destination Marketing Organisations (DMO) operate in a fast changing environment with ongoing challenges to face. Digitalisation is one of the issues that DMOs have to handle. As a result, we can see that many tourism offices are closed down in Sweden. However, has new te

Characterization of Drosophila Nidogen/entactin reveals roles in basement membrane stability, barrier function and nervous system patterning

Basement membranes (BMs) are specialized layers of extracellular matrix (ECM) mainly composed of Laminin, type IV Collagen, Perlecan and Nidogen/entactin (NDG). Recent in vivo studies challenged the initially proposed role of NDG as a major ECM linker molecule by revealing dispensability for viability and BM formation. Here, we report the characterization of the single Ndg gene in Drosophila. Embr

Primary Prevention of Sudden Cardiac Death With Implantable Cardioverter-Defibrillator Therapy in Patients With Arrhythmogenic Right Ventricular Cardiomyopathy

Implantable cardioverter-defibrillator (ICD) therapy remains a corner stone of sudden cardiac death (SCD) prevention in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). We aimed to assess predictors of appropriate ICD therapies in the Scandinavian cohort of ARVC patients who received ICD for primary prevention of SCD. Study group comprised of 79 definite ARVC patients by 2010