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Desmoplastic small round cell tumor (DSRCT) is a highly aggressive soft tissue tumor primarily affecting children and young adults. Most cases display a pathognomonic EWSR1-WT1 gene fusion, presumably constituting the primary driver event. Little is, however, known about secondary genetic changes that may affect tumor progression. We here studied 25 samples from 19 DSRCT patients using single nucl
Exposure to fine particulate air pollution (PM2.5) is emerging as a risk factor for Alzheimer's disease (AD), but existing studies are still limited and heterogeneous. We have previously studied the association between dementia (AD and vascular dementia) and PM2.5 stemming from vehicle exhaust and wood-smoke in the Betula cohort in Northern Sweden. The aim of this commentary is to estimate the ass
We all want to develop impactful and valuable theories, but what do we mean by ‘theory’? In this piece, we reply to the four readers’ comments on a recent paper in which we propose a theory typology that, in comparison to existing literature, offers a considerably broader, more pluralistic and, at the same time, more precise definition of the meaning(s) of ‘theory’ within academia. In their commen
Membrane proteins (MPs) constitute a large fraction of the proteome, but exhibit physicochemical characteristics that impose challenges for successful sample production crucial for subsequent biophysical studies. In particular, MPs have to be extracted from the membranes in a stable form. Reconstitution into detergent micelles represents the most common procedure in recovering MPs for subsequent a
This article describes and critically examines the challenging task of compiling The London–Lund Corpus 2 (LLC–2) from start to end, accounting for the methodological decisions made in each stage and highlighting the innovations. LLC–2 is a half-a-million-word corpus of contemporary spoken British English with recordings from 2014 to 2019. Its size and design are the same as those of the world's f
The idea of this special issue on Spoken language in time and across time emerged at an international symposium on this topic that we organised at Lund University on 20 September 2019. The purpose of the symposium was to celebrate important past and present achievements of spoken language research as well as past and present corpora available for such research. Some speakers reported on academic a
This article aims to describe key challenges of preparing and releasing audio material for spoken data and to propose solutions to these challenges. We draw on our experience of compiling the new London-Lund Corpus 2 (LLC-2), where transcripts are released together with the audio files. However, making the audio material publicly available required careful consideration of how to, most effectively
Monoclonal gammopathies involving immunoglobulin E (IgE) is a very rare phenomenon, with less than 70 cases being previously described in the literature. The IgE monoclonal gammopathies include malignant plasma cell disorders such as IgE multiple myeloma (MM), as well as the associated premalignant condition IgE monoclonal gammopathy of undetermined significance (MGUS). We report a case of a 41-ye
The adaptive matched filter (AMF) is a method widely used in spectral unmixing to classify different tissue chromophores in photoacoustic images. However, a threshold needs to be applied to the AMF detection image to distinguish the desired tissue chromophores from the background. In this study, we propose an automatic threshold selection (ATS) algorithm capable of differentiating a target from th
Flood risk is a complex and transboundary issue that is expected to escalate with climate change and requires to be governed by collaborative networks of actors. Municipal administrations have been suggested to have a particularly important and challenging role in such governance. Although collaborative governance has attracted intense scientific attention, empirical studies generally focus either
We examine time allocation decisions in same-sex and different-sex couples from a Beckerian comparative advantage perspective. In particular, we estimate the comparative advantage relationship between time spent on either market or household activities and a dummy for being the highest earner in a couple on samples of same-sex and different-sex couples. Using the American Time Use Survey (ATUS), w
Functional electrical stimulation (FES) is used for treating foot drop by delivering electrical pulses to the anterior tibialis muscle during the swing phase of gait. This treatment requires that a patient can walk, which is mostly possible in the later phases of rehabilitation. In the early phase of recovery, the therapy conventionally consists of stretching exercises, and less commonly of FES de
A pandemic is a crisis and as such, in many ways, an entirely new situation . It is a situation in which there are scientific as well as societal uncertainties and where the routines of everyday life are overturned . The Covid-19 pandemic has made visible already established social structures and inequalities, but it has also exacerbated existing power relations and vulnerabilities . In this artic
The present thesis aims at studying n-heptane/methanol dual-fuel combustion under internal combustion engine conditions and strives to improve the understanding of its ignition, combustion, and pollutant emission mechanisms. Large-eddy simulation (LES) coupled with Eulerian stochastic fields (ESF) approach is employed to simulate single/dual-fuel combustion in a constant-volume vessel to mimic the
We study family firm status as an important condition in signaling theory; specifically, we propose that the market reacts more positively to positive, and more negatively to negative, CSR news (i.e., signals) from family firms than to similar news from nonfamily firms. Moreover, we propose that during recessions, the direction of these relationships reverses. Based on an event study of 1247 posit
An elastoplastic topology optimization framework for limiting plastic work generation while maximizing stiffness is presented. The kinematics and constitutive model are based on finite strain linear isotropic hardening plasticity, and the balance laws are solved using a total Lagrangian finite element formulation. Aggregation of the specific plastic work combined with an adaptive normalization sch
Aims and objectives: To describe ways in which children's best interests were observed to be expressed in paediatric settings during their hospital visit.Background: The best interests of the child are embodied in national and international legal systems, although the definition remains problematic. The child's limited autonomy mandates duty bearers to have both a child perspective and the child's
