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Quantification of egg proteome changes during fertilization in sterlet Acipenser ruthenus

Eggs of sterlet are discharged outside into ambient aquatic environment where egg activation and fertilization occur. Effects of different activation media including freshwater and clay suspension on protein abundances of egg were quantified in sterlet Acipenser ruthenus. In-gel digestion and high resolution mass spectrometry were used for label-free protein quantification in the eggs of five fema

Effects of the layout of film holes near the vane leading edge on the endwall cooling and phantom cooling of the vane suction side surface

In the current research, effects of the layout of film holes near the first-stage vane leading edge on the endwall cooling and phantom cooling of the vane suction side surface were numerically studied. The computational results indicate that the case with a positive film-hole angle achieves a higher cooling effectiveness level on the endwall and vane suction side surface compared to the case with

Two-phase flow simulation of mist film cooling with deposition for various boundary conditions

Air film cooling is a conventional cooling technique that has been successfully used for gas turbine hot-section components, such as combustor liners, combustor transition pieces, and turbine vanes and blades. However, the increased benefit seems to approach a limit. This paper investigates the film cooling effectiveness considering mist injection. All the studies for various boundary conditions a

Quasi-universality in mixed salt-free counterion systems

The screening of plate-plate interactions by counterions is an age-old problem. We revisit this classic question when counterions exhibit a distribution of charges. While it is expected that the long-distance regime of interactions is universal, the behaviour of the inter-plate pressure at smaller distances should a priori depend rather severely on the nature of the ionic mixture screening the pla

Experimental and numerical analysis of spring stiffness on flow and valve core movement in pilot control globe valve

Valves are widely used for fluid flow control, not only for conventional fluid like water, gas and oil, but also for hydrogen under high pressure and so forth. Under these new conditions, the response time and energy consumption of valves are closely related to the whole performance of the piping system. Pilot-control globe valve (PCGV) is a novel quick response valve, which can utilize the pressu

Transcribing β-cell mitochondria in health and disease

Background: The recent genome-wide association studies (GWAS) of Type 2 Diabetes (T2D) have identified the pancreatic β-cell as the culprit in the pathogenesis of the disease. Mitochondrial metabolism plays a crucial role in the processes controlling release of insulin and β-cell mass. This notion implies that mechanisms controlling mitochondrial function have the potential to play a decisive path

Numerical and Experimental Study on Laminar Methane/Air Premixed Flames at Varying Pressure

Laminar methane/air premixed Bunsen flames were studied using detailed numerical simulations and laser diagnostics. In the numerical simulations one-dimensional and two-dimensional configurations were considered with detailed transport properties and chemical kinetic mechanism. In the measurements OH PLIF was employed. The flame structures vary with varying equivalence ratio and pressure. For stoi

PBB3 imaging in Parkinsonian disorders : Evidence for binding to tau and other proteins

BACKGROUND AND OBJECTIVES: To study selective regional binding for tau pathology in vivo, using PET with [(11) C]PBB3 in PSP patients, and other conditions not typically associated with tauopathy.METHODS: Dynamic PET scans were obtained for 70 minutes after the bolus injection of [(11) C]PBB3 in 5 PSP subjects, 1 subject with DCTN1 mutation and PSP phenotype, 3 asymptomatic SNCA duplication carrie

Socially extended intentions-in-action

According to a widely accepted constraint on the content of intentions, here called the exclusivity constraint, one cannot intend to perform another agent’s action, even if one might be able to intend that she performs it. For example, while one can intend that one’s guest leaves before midnight, one cannot intend to perform her act of leaving. However, Deborah Tollefsen’s (2005) account of joint

Social exclusion modulates pre-reflective interpersonal body representation

Perception of an affordance is enhanced not only when the relevant object is located in one’s own peripersonal space, as compared to when it is located within extrapersonal space, but also when the object is located in another person’s peripersonal space (as measured by a Spatial Alignment Effect (SAE)). It has been suggested that this reflects the existence of an interpersonal body representation

Shared intention and the doxastic single end condition

What is required for several agents to intentionally φ together? I argue that each of them must believe or assume that their φ-ing is a single end that each intends to contribute to. Various analogies between intentional singular action and intentional joint action show that this doxastic single end condition captures a feature at the very heart of the phenomenon of intentional joint action. For i

Shared Goals and Development

In 'Joint Action and Development', Stephen Butterfill argues that if several agents' actions are driven by what he calls a "shared goal" -- a certain pattern of goal-relations and expectations -- then these actions constitute a joint action. This kind of joint action is sufficiently cognitively undemanding for children to engage in, and therefore has the potential to play a part in fostering their