In this study, we investigated how prolonged consumption of sugar solution affects hippocampal neurogenesis. We gave rats sucrose or fructose solution for four weeks and observed a 40% reduction in BrdU/NeuN-immunoreactive cells in the hippocampal dentate gyrus. This reduction in hippocampal neurogenesis was accompanied by increased apoptosis in the hippocampus and increased circulating levels of

The Symphony study showed that at 1 year posttransplant, a regimen based on daclizumab induction, 2 g mycophenolate mofetil (MMF), low-dose tacrolimus and steroids resulted in better renal function and lower acute rejection and graft loss rates compared with three other regimens: two with low-doses of cyclosporine or sirolimus instead of tacrolimus and one with no induction and standard cyclospori

We study the MIMO wireless channel, and derive a generic channel model that we believe has the ability to explain all important effects, including (i) interdependency of directions-of-arrival and directions-of-departure, (ii) large delay and angle dispersion by propagation via far clusters, (iii) rank reduction of the transfer function matrix. We point out the relevant propagation effects, and pro

The paper discusses modeling and analysis of real-time systems subject to random time delays in the communication network. A new method for analysis of different control schemes is presented. The method is used to evaluate different suggested schemes from the literature. A new scheme, using so called timestamps, for handling the random time delays is then developed and successfully compared with p

Little is known about pediatric surgical disease in resource-poor countries. This study documents the surgical care of children in central Haiti and demonstrates the influence of the 2010 earthquake on pediatric surgical delivery. METHODS: We conducted a retrospective review of operations performed at Partners in Health/Zanmi Lasante hospitals in central Haiti. RESULTS: Of 2,057 operations perfor

This paper presents a solution to the problem of pose estimation in the presence of heavy radial distortion and a potentially large number of outliers. The main contribution is an algorithm that solves for radial distortion, focal length and camera pose using a minimal set of four point correspondences between 3D world points and image points. We use a RANSAC loop to find a set of inliers and an i

Gestures, i.e. the symbolic movements that speakers perform while they speak, form a closely interconnected system with speech, where gestures serve both addressee-directed (‘communicative’) and speaker-directed (‘internal’) functions. This article aims (1) to show that a combined analysis of gesture and speech offers new ways to address theoretical issues in second language acquisition (SLA) and

The editorial outlines our main reasons for bringing scholarly attention to thetheme of Scandinavian art cinema and screen cultures in transition at this moment.It provides brief summaries of the issue’s five feature articles and presents somesuggestions for further research on the topic. We stress the importance of takinggender into account in future studies and call for a closer dialogue and mor

Advanced breast cancers represent a major therapeutic challenge due to their refractoriness to treatment. Cancer-associated fibroblasts (CAFs) are the most abundant constituents of the tumor microenvironment and have been linked to most hallmarks of cancer. However, the influence of CAFs on therapeutic outcome remains largely unchartered. Here, we reveal that spatial coincidence of abundant CAF in

BACKGROUND AND PURPOSE: High resolution 7T MRI is increasingly used to investigate hippocampal subfields in vivo, but most studies rely on manual segmentation which is labor intensive. We aimed to evaluate an automated technique to segment hippocampal subfields and the entorhinal cortex at 7T MRI.MATERIALS AND METHODS: The cornu ammonis (CA)1, CA2, CA3, dentate gyrus, subiculum, and entorhinal cor

INTRODUCTION: It is unclear the degree to which tau pathology in the medial temporal lobe (MTL) measured by 18F-flortaucipir positron emission tomography relates to MTL subregional atrophy and whether this relationship differs between amyloid-β-positive and amyloid-β-negative individuals.METHODS: We analyzed correlation of MTL 18F-flortaucipir uptake with MTL subregional atrophy measured with high

Medial temporal lobe (MTL) substructures are the earliest regions affected by neurofibrillary tangle pathology-and thus are promising biomarkers for Alzheimer's disease (AD). However, automatic segmentation of the MTL using only T1-weighted (T1w) magnetic resonance imaging (MRI) is challenging due to the large anatomical variability of the MTL cortex and the confound of the dura mater, which is co