Background and Objectives Small vessel disease (SVD) and neuroinflammation both occur in Alzheimer disease (AD) and other neurodegenerative diseases. It is unclear whether these processes are related or independent mechanisms in AD, especially in the early stages of disease. We therefore investigated the association between white matter lesions (WML; the most common manifestation of SVD) and CSF b

This study aimed to determine the optimal method for extracting rosmarinic acid (RA) from lemon balm using pressurized liquid extraction (PLE). Additionally, the effect of filtration during sample preparation on the concentration of rosmarinic acid (RA) was investigated. Moreover, the RA content was compared in various lemon balm samples including: commercial dried lemon balm, commercial lemon bal

The article opposes the view that marginality is a decisive trait of Swedish alternative care practitioners. Instead, factors such as the structural looseness of these occupational roles and the fact that the practitioners belong to no specific work organization is stressed. The practitioners have to demonstrate the legitimacy of their work and enforce the boundaries around their work ethics by th

In October 2022, the European Commission announced a legislative proposal to make instant payments in euro available to all citizens with a bank account in the EU and EEA countries. When adopting new payment technologies, it can be challenging to balance security and convenience. Consideration must be given to whether compromised security is an unavoidable effect of instant payments or if both obj

BackgroundSince the 1960s, women’s social and political engagement in Japan has been closely tied to the roles of mothers and housewives. On the other hand, the country is undergoing considerable demographic changes and has come to be considered an aging society, where an increasing number of women are opting out of marriage and child-rearing. Drawing from qualitative research with women in manage

The social dimensions of resilience and their relationship with social capital have received little attention in climate change research. This article aims to provide an understanding of the structural, cognitive, and human rights-based interconnection of social capital and the social dimension of resilience. This article provides a rapid review of published studies on the social dimensions of res

Objective: To determine whether a gout polygenic risk score (PRS) is associated with age at gout onset and tophaceous disease in European, East Polynesian, and West Polynesian men and women with gout. Methods: A 19-variant gout PRS was produced in 7 European gout cohorts (N = 4,016), 2 East Polynesian gout cohorts (N = 682), and 1 West Polynesian gout cohort (N = 490). Sex-stratified regression mo

Recombinant α1-microglobulin (A1M) is a proposed radioprotector during 177Lu-octreotate therapy of neuroendocrine tumors (NETs). To ensure a maintained therapeutic effect, we previously demonstrated that A1M does not affect the 177Lu-octreotate induced decrease in GOT1 tumor volume. However, the underlying biological events of these findings are still unknown. The aim of this work was to examine t

Over decades the Ag 3d-level binding energy has been puzzling researchers with its unusual sign and value in silver oxides. For the absolute majority of metals, the metal-to-oxide binding energy shifts are positive and depend significantly on the oxidation state, while in Ag-oxides the oxide shift was time after time reported negative, small, and close for the two very different Ag(I) and Ag(III)

The inherited eye disease retinitis pigmentosa (RP) causes the loss of photoreceptors by a still unknown cell death mechanism. During this degeneration, cyclic guanosine-3′,5′-monophosphate (cGMP) levels become elevated, leading to over-activation of the cGMP-binding protein cGMP-dependent protein kinase (PKG). cGMP analogs selectively modified to have inhibitory actions on PKG have aided in imped

Due to the upsurge of interest in the field of sustainability, and specifically circular economy, it is of increasing importance for companies to dedicate themselves to greener business models and initiatives that step away from the linearity that is currently predominant. One way in which circularity can be implemented is through effective communication towards customers to incorporate them into

Purpose: The purpose of this research was to investigate how outdoor textile brands align their brand bdentity with their management actions and communication to become more circular. It was as a consequence explored how communication strategies of outdoor brands align with their management decision and how management actions push the transition of a brand towards more circularity. Methodology: Th

A 23 factorial design experiment was conducted to study the influence of pre-heating temperature (HT) for manufacturing sample, bonding temperature (BT) onto rheometer, and trimming state (Trim) of the sample on complex shear modulus (G*) and phase angle (δ) using a dynamic shear rheometer on unmodified bitumen of types 50/70, 70/100, and two 160/220 from various sources. In addition, the black di

The double quantum coherence (DQC) signal in nonlinear spectroscopy gives information about the many-body correlation effects not easily available by other methods. The signal is short-lived, consequently, a significant part of it is generated during the pulse overlap. Since the signal is at two times the laser frequency, one may intuitively expect that the pulse overlap-related artifacts are filt

OBJECTIVE: To report population-based clinical presentation and outcomes in patients with urosymphyseal fistula (USF) after pelvic radiotherapy (RT). PATIENTS AND METHODS: A retrospective chart review was performed in 33 consecutive patients diagnosed with suspicion of USF in a tertial referral center from 2014-2022 to ascertain information about diagnostic delay, clinical presentation, precipitat