Despite the growing importance of real-world evidence (RWE) for guiding clinical decisions in retinal disease, there is currently no widely used guidance available for assessing the quality and relevance of RWE studies in ophthalmology. This paper summarizes the development of a user-friendly tool that facilitates assessment of the quality of available RWE for neovascular age-related macular degen

We show in this study the impact of transglutaminase (SB6), glycerol (Gly) and linoleic acid (LA) on the development of gliadin (Glia) solid edible foams. Two concentrations of SB6 were tested, 0.58 U/g and 1.17 U/g, and sufficiently high concentration of SB6 was found essential to crosslink the gliadins. Greater cross-linking in foam prepared with gliadin and 1.17 U/g of SB6 (2-TG-Glia) was follo

The majority of northern peatlands were initiated during the Holocene. Owing to their mass imbalance, they have sequestered huge amounts of carbon in terrestrial ecosystems. Although recent syntheses have filled some knowledge gaps, the extent and remoteness of many peatlands pose challenges to developing reliable regional carbon accumulation estimates from observations. In this work, we employed

The Arctic is getting warmer and wetter. Here, we document two independent examples of how associated extreme precipitation patterns have severe implications for high Arctic ecosystems. The events stand out in a 23-year record of continuous observations of a wide range of ecosystem parameters and act as an early indication of conditions projected to increase in the future. In NE Greenland, August

Text visualization and visual text analytics methods have been successfully applied for various tasks related to the analysis of individual text documents and large document collections such as summarization of main topics or identification of events in discourse. Visualization of sentiments and emotions detected in textual data has also become an important topic of interest, especially with regar

Propagation models constitute a fundamental building block of wireless communications research. Before we build and operate real systems, we must understand the science of radio propagation, and develop channel models that both reflect the important propagation processes and allow a fair comparison of different systems. In the past five decades, wireless systems have gone through five generations,

Economic geographers have recently made important contributions to understanding of the relationship between regional transformation, industrial specialisation and innovation networks in the emergence of new industries. However, most contemporary research has focused on the influence of networks on regional trajectories, paying lip service to how regional trajectories also influence network config

Anisotropic flow coefficients, vn, non-linear flow mode coefficients, χn,mk, and correlations among different symmetry planes, ρn,mk are measured in Pb-Pb collisions at sNN = 5.02 TeV. Results obtained with multi-particle correlations are reported for the transverse momentum interval 0.2 < pT< 5.0 GeV/c within the pseudorapidity interval 0.4 < |η| < 0.8 as a function of collision centrality. The v

Curved crystal surfaces enable the systematic and accurate comparison of physical and chemical processes for a full set of vicinal crystal planes, which are probed in the very same environment. Here, we examine the early stages of the CO chemisorption on vicinal Rh(111) surfaces using a curved Rh crystal that exposes a smoothly variable density of {100} (A-type) and {111} (B-type) steps. We readil

In this study, we explore whether first language (L1) attrition affects the use of prosodic cues in anaphora resolution. 18 late Italian–Swedish bilinguals completed a speech production task in L1 Italian, wherein we measured the inter-clausal pause duration and the pronoun’s degree of prosodic prominence. They also completed a control interpretation task, wherein we analysed response preferences,

Background: Will being a caregiver further impact the health of a group already at risk of adverse health due to old age? This study aimed to answer the questions whether short- and long-term healthcare consumption and mortality differ between informal caregivers and non-caregivers and between high-burden and low-burden informal caregivers. Method: The study population consisted of 423 caregivers

Many industries, which are producing sludge in large quantities, depend on sludge dewatering technology to reduce the corresponding water content. A key design parameter for dewatering equipment is the capillary suction time (CST) test, which has, however, several scientific flaws, despite that the test is practical and easy-to-perform. The standard CST test has a few considerable drawbacks: its l

In this study, microparticle coatings and nanoparticle coatings were fabricated on copper surfaces by an electrochemical deposition method and an electrophoretic deposition method, respectively. Pool boiling of NOVEC-649 was experimentally studied on the coated surfaces, concerning heat transfer, bubble dynamics, and critical heat fluxes. Compared with a smooth surface, heat transfer coefficients

Transfer RNAs (tRNAs) are central adaptors that decode genetic information during translation and have been long considered static cellular components. However, whether dynamic changes in tRNAs and tRNA-derived fragments actively contribute to gene regulation remains debated. In this issue, Huh et al (2020) highlight tyrosine tRNAGUA fragmentation at the nexus of an evolutionarily conserved adapti

This paper examines an artefact type of unknown function, found in several places across medieval England. These artefacts are mostly made from goose radii, but other species, such as chicken and hare, are also known. The worked radii have often been interpreted as being related to writing, but a closer examination suggests that they are more likely to be awls.

Research Question/Issue: On the basis of a dynamic interrelation between the assumptions of agency theory and stewardship theory, this study seeks to make sense of disobedience at the highest corporate level. Departing from a processual view in order to better understand how loyalty plays a critical role in the relationships between a CEO and his/her principal, we propose a conceptualization of th

The thermal state of a glow discharge with intermediate current in flowing atmospheric air is investigated by a combination of Rayleigh scattering thermometry imaging and numerical simulation. Results from the simulation indicate that during the initial breakdown the local translational temperature can reach a huge value (e.g. 6000 K) but decreases quickly due to strong heat transfer to the surrou

Background: The standard reference region (RR) for amyloid-beta (Aβ) PET studies is the cerebellar grey matter (GMCB), while alternative RRs have mostly been utilized without prior validation against the gold standard. This study compared five commonly used RRs to gold standard plasma input-based quantification using the GMCB. Methods: Thirteen subjects from a test–retest (TRT) study and 30 from a

Objective: The optimal duration of venoarterial extracorporeal membrane oxygenation (VA-ECMO) in patients affected by postcardiotomy cardiogenic shock (PCS) remains controversial. The present study was conducted to investigate the effect of VA-ECMO duration on hospital outcomes. Design: Retrospective analysis of an international registry. Setting: Multicenter study including 19 tertiary university