Ionic microgel particles are intriguing systems in which the properties of thermo-responsive polymeric colloids are enriched by the presence of charged groups. In order to rationalize their properties and predict the behaviour of microgel suspensions, it is necessary to develop a coarse-graining strategy that starts from the accurate modelling of single particles. Here, we provide a numerical adva

Soft colloids are increasingly used as model systems to address fundamental issues such as crystallization and the glass and jamming transitions. Among the available classes of soft colloids, microgels are emerging as the gold standard. Since their great internal complexity makes their theoretical characterization very hard, microgels are commonly modeled, at least in the small-deformation regime,

We study colloidal gels formed by competing electrostatic repulsion and short-range attraction by means of extensive numerical simulations under external shear. We show that, upon varying the repulsion strength, the gel structure and its viscoelastic properties can be largely tuned. In particular, the gel fractal dimension can be either increased or decreased with respect to mechanical equilibrium

Injektion av specifikt utvalt DNA i celler är en teknik som har många användningsområden, tillexempel i cell- och genterapier men också för att studera orsaker till olika sjukdomar som diabetes. Målet med att introducera DNA är att få cellen att bete sig på ett önskat sätt. Anledningen till detta kan vara för att antingen kunna använda cellen som en behandling mot cancer, eller för att åstadkomma Electroporation is a technique used to transfect cells, i.e. to introduce nucleic acids in cells. The method consists in applying a voltage over the cells which leads to the opening of pores in the cell membrane through which cargo can diffuse to the cell interior. If the cells are cultivated on top of nanopores or nanostraws, dielectric structures one can achieve nanoelectroporation when applying

We consider differential Lyapunov and Riccati equations, and generalized versions thereof. Such equations arise in many different areas and are especially important within the field of optimal control. In order to approximate their solution, one may use several different kinds of numerical methods. Of these, splitting schemes are often a very competitive choice. In this article, we investigate the

The municipality of Nacka is undergoing major urban development and transformation which is part of the project [Nacka becomes a city] which includes new developments of housing, commercial property, and shopping areas aimed to make Nacka a city. The project is driven by the expansion of the Stockholm metro system which is getting extended to Nacka. Such major changes of an urban area in correlati

The consultation process in Swedish planning provides an opportunity for citizens to participate in the planning process. Yet the influence of the citizens is varied and their ability to interact with the planners and the developer can sometimes be problematic. Using Haberma’s theory of communicative action, this study analyzes the interactions between the planners, contractors and citizens in the

The prevalence of alopecia has increased recently. Hair loss is often accompanied by the resting phase of hair follicles (HFs). Dermal papilla (DP) plays a crucial role in HF development, growth, and regeneration. Activating DP can revive resting HFs. Augmenting WNT/β-catenin signaling stimulates HF growth. However, the factors responsible for activating resting HFs effectively are unclear. In thi

Marine copepods, the most abundant animals in the global ocean, imprint their surrounding waters with chemical cues, called copepodamides. Copepodamides induce defensive traits such as toxin production, bioluminescence, and colony size plasticity in a variety of marine phytoplankton. The role of copepodamides in freshwater ecosystems is, however, unknown. Here we report the consistent presence of

Introduction: Pre-analytical factors can cause substantial variability in the measurements of cerebrospinal fluid (CSF) and plasma biomarkers of Alzheimer’s disease (AD). However, their effects on the performance of one of the most promising plasma AD biomarkers, phosphorylated tau (p-tau)217, are not known. Methods: We included 50 amyloid-β positive (Aβ+) and 50 Aβ− participants from the Swedish

Context. Globular clusters (GCs) carry information about the formation histories and gravitational fields of their host galaxies. It was found before that the radial profiles of the volume number density of GCs in GC systems (GCSs) follow broken power laws, while the breaks occur approximately at the a0 radii. These are the radii at which the gravitational fields of the galaxies equal the galactic

Objectives: In patients with axial spondyloarthritis (axSpA) or psoriatic arthritis (PsA) initiating secukinumab, we aimed to assess and compare the proportion of patients achieving 6-, 12- and 24-month patient-reported outcomes (PRO) remission and the 24-month retention rates. Patients and methods: Patients with axSpA or PsA from 16 European registries, who initiated secukinumab in routine care w

Self-replication of amyloid fibrils via secondary nucleation is an intriguing physicochemical phenomenon in which existing fibrils catalyze the formation of their own copies. The molecular events behind this fibril surface-mediated process remain largely inaccessible to current structural and imaging techniques. Using statistical mechanics, computer modeling, and chemical kinetics, we show that th

The manipulation of nano-objects through heating is an effective strategy for inducing structural modifications and therefore changing the optoelectronic properties of semiconducting materials. Despite its potential, the underlying mechanism of the structural transformations remains elusive, largely due to the challenges associated with their in situ observations. To address these issues, we synth

The aim of this study was to explore the longitudinal association between reported baseline water intake and incidence of coronary artery disease (CAD) and type 2 diabetes in the Malmö Diet and Cancer Cohort (n = 25,369). Using cox proportional hazards models, we separately modelled the effect of plain and total (all water, including from food) water on CAD and type 2 diabetes risk, whilst adjusti

We compute the heavy quark momentum diffusion coefficient κ using QCD kinetic theory for a system going through bottom-up isotropization in the initial stages of a heavy ion collision. We find that the values of κ are within 30% from a thermal system at the same energy density. When matching for other quantities we observe considerably larger deviations. We also observe that the diffusion coeffici

Hypothesis: Colloidal molecules with anisotropic shapes and interactions are powerful model systems for deciphering the behavior of real molecules and building units for creating materials with designed properties. While many strategies for their assembly have been developed, they typically yield a broad distribution or are limited to a specific type. We hypothesize that the shape and relative siz

We demonstrate a microwave power-to-electrical energy conversion in a resonator-coupled double quantum dot. The system, operated as a photodiode, converts individual microwave photons to electrons tunneling through the double dot, resulting in an electrical current flowing against the applied voltage bias at input powers down to 1 fW. The device attains a maximum power harvesting efficiency of 2%,

Recent progress has been made in the numerical modelling of neutral microgel particles with a realistic, disordered structure. In this work we extend this approach to the case of co-polymerised microgels where a thermoresponsive polymer is mixed with acidic groups. We compare the cases where counterions directly interact with microgel charges or are modelled implicitly through a Debye-Hückel descr