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Structure of the human ClC-1 chloride channel

ClC-1 protein channels facilitate rapid passage of chloride ions across cellular membranes, thereby orchestrating skeletal muscle excitability. Malfunction of ClC-1 is associated with myotonia congenita, a disease impairing muscle relaxation. Here, we present the cryo-electron microscopy (cryo-EM) structure of human ClC-1, uncovering an architecture reminiscent of that of bovine ClC-K and CLC tran

On the observed diversity of star formation efficiencies in Giant Molecular Clouds

Observations find a median star formation efficiency per free-fall time in Milky Way Giant Molecular Clouds (GMCs) of the order of ϵff∼1 per cent with dispersions of ∼0.5dex⁠. The origin of this scatter in ϵff is still debated and difficult to reproduce with analytical models. We track the formation, evolution and destruction of GMCs in a hydrodynamical simulation of a Milky Way-like galaxy and by

Supernovae feedback propagation: the role of turbulence

Modelling the propagation of supernova (SN) bubbles, in terms of energy, momentum, and spatial extent, is critical for simulations of galaxy evolution which do not capture these scales. To date, small-scale models of SN feedback predict that the evolution of above-mentioned quantities can be solely parametrized by average quantities of the surrounding gas, such as density. However, most of these s

Silent Timber Build - Development of low frequency vibroacoustic prediction tools for lightweight wooden constructions

The goal of the Silent Timber Build project is to develop new prediction tools for timber structures. As a matter of fact, impact sound insulation in the low frequency range is a crucial point concerning satisfaction of lightweight wooden-based building residents. Floor systems are rather complex: multi-layered, multi-cavity, stiffened, with floor covering and ceiling (either rigidly connected, su

The nature of damped HI absorbers probed by cosmological simulations: satellite accretion and outflows

We use cosmological hydrodynamic zoom simulations to study the neutral gas distributionin and around galaxies that gives rise to high column density HILyαabsorption (dampedLyαsystems (DLAs) and sub-DLAs) in background quasar spectra. Such simulations oftensacrifice numerical resolution for volume that affects the lower density galaxy halo gas,and simulations have difficulties reproducing the span

Modelling guidelines for simulating low frequency vibroacoustic performance in wooden T-junctions

Efficient and accurate numerical tools for predicting the vibroacoustic behaviour of wooden multi-storey buildings are lacking nowadays. The variability that a natural material as wood possesses, makes it difficult to accurately predict and model its behaviour. Likewise, construction details such as junctions and connections between structural elements play an important role in the dynamic respons