This thesis is focused on the early steps of a complex virus-cell interaction. The human adenovirus type 2 (HAdV-2) infects permissive cells, by first recognizing a protein of the immunoglobulin superfamily that serves as the Coxsackie and adenovirus receptor (CAR). This attachment step is mediated by the adenovirus fiber protein. Subsequently, in order to proceed to a tighter binding, the viral p

Popular Abstract in Swedish Makrofager återfinns i stort sett överallt i kroppen. De bildas från stamceller i benmärgen och cirkulerar i blodomloppet tillsammans med andra vita blodkroppar i form av monocyter, som kan vandra igenom blodkärlens väggar och vidareutvecklas till makrofager ute i vävnaderna. Makrofagen spelar en viktig roll i kroppens totalförsvar genom att vägleda och orkestrera immunMacrophages mediate innate immunity through release of cytokines, eicosanoids, reactive oxygen species as well as through phagocytosis and secretion of lysosomal enzymes. Regulation of lysosomal secretion in macrophages differs in several respects from release of specialized granules in other leukocytes. Lysosomal secretion is not dependent upon cytosolic calcium but is instead triggered by lysoso

Abstract in Undetermined I detta kapitel har vi beskrivit psykologbedömningar på individnivå och satt in dessa i sin kontext. Vi har lyft fram betydelsen av att se eleven i sitt sammanhang – hemma såväl som i skolan – samt betonat vikten av de systemteoretiska faktorer som påverkar skolframgång, exempelvis lärarnas metoder och deras möjlighet att få pedagogiskt stöd. Detta är faktorer som är förän

Investigation of human movement in the past has been a confounding issue in archaeology. Direct measurement of past mobility has recently become feasible, however, through the application of strontium isotope analysis to human skeletal remains. In this study, we examine the question of changes in residence and place of origin among the inhabitants of the landscape of south-central Sweden. We focus

The pancreatic islet beta-cells are the target for an autoimmune process that eventually results in an inability to control blood glucose due to the lack of insulin. The different steps that eventually lead to the complete loss of the beta-cells are reviewed to include the very first step of a triggering event that initiates the development of beta-cell autoimmunity to the last step of appearance

To study cell-free fetal hemoglobin (HbF) and the heme-scavenger α1- microglobulin (A1M) in patients with manifest preeclampsia (PE) and how these proteins performed as possible biomarkers of PE and adverse maternal and fetal outcomes.