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The paper explores the role and meaning of maṣlaḥa (social utility) and its possible appropriation in the field of Islamic legal and economic thought, as laid down by various medieval and contemporary Muslim scholars. Questions that are pertinent to the research are the following: how has maṣlaḥa been incorporated in legal reasoning and what kind of meaning does it convey; what type of economic (a
Background & Aims: Biomarkers are needed to identify individuals at elevated risk of inflammatory bowel disease. This study aimed to identify protein signatures predictive of inflammatory bowel disease. Methods: Using large population-based cohorts (n ≥180,000), blood samples were obtained from individuals who later in life were diagnosed with inflammatory bowel disease and compared with age a
Purpose There is a need for diagnostic and prognostic biosignatures to improve long-term outcomes in inflammatory bowel disease (IBD). Here, we describe the establishment of the Swedish Inception Cohort in IBD (SIC-IBD) and demonstrate its potential for the identification of such signatures. Participants Patients aged ≥18 years with gastrointestinal symptoms who were referred to the gastroenterolo
Marcus Tullius Ciceros verk Brutus, också känt under titeln De claris oratoribus, är en framställning i dialogform av talarkonsten i Rom. Cicero själv har huvudrollen i berättelsen som byggs upp kring Marcus Junius Brutus (den mest namnkunnige av de blivande Caesarmördarna) och Titus Pomponius Atticus (en nära vän till Cicero, från Athen) vilka när de råkar på Cicero ber honom berätta om den romer
The aim of this this cross-sectional observational study was to investigate coagulation and platelet activation in blood collected from newly inserted catheters. Blood samples were collected from newly inserted central venous, peripheral venous and arterial catheters in adult patients. Sample 1 was collected within seconds after insertion. Sample 2 was collected directly after Sample 1 but after p
BACKGROUND: Mental health service users often experience difficulties interpreting and regulating sensory stimuli resulting in increased anxiety, decreased abilities to engage in activities and a hampered recovery process. However, there are limited studies on the implementation of such recovery-oriented interventions targeting sensory difficulties via sensory modulation techniques. Therefore, the
Understanding the hydromechanical behavior of porous media such as sandstones is critical to various geoengineering applications such as geologic carbon storage, geothermal projects, oil and gas production and environmental remediation in aquifers. In these contexts, accurate quantification of the constitutive hydromechanical behavior of sandstones is necessary to predict reservoir responses. In t
Background: Evidence on psychological outcomes of gaming disorder (GD) is still scarce. This study aimed to investigate the mediating role of sleep hygiene in the relationship between GD and psychological distress (depression and anxiety) among Iranian adolescents. Methods: This was a cross-sectional study among school students in Qazvin city, Iran. We administered GD, anxiety, and depression ques
Background: Several cancer types have increased PFKFB3, a glycolytic enzyme for which potent inhibitors have been found. Inhibition of PFKFB3 impairs DNA repair after irradiation of cancer cells, making it a possible radiosensitization target. The SweBCG91RT trial, in which breast cancer patients were randomized to postoperative radiotherapy or not, was used to investigate PFKFB3 as a clinical mar
Monitoring agricultural land with optical remote sensing offers a valuable tool for estimating crop yield and supporting decision-making for food security. Cropland phenology indicators, such as the start of season (SOS), the end of season (EOS), and the number of growing seasons per year, provide essential information for land managers. While established toolboxes like TIMESAT have been extractin
The functionalization of cubosomes for their use in drug delivery, bioimaging, and biosensing can be achieved by incorporating molecules that are sensitive to physiological conditions, such as phospholipids. Considering this, it is relevant to investigate the interaction between phospholipid-containing cubosomes and phospholipase A2 (PLA2), a ubiquitous enzyme associated with inflammatory diseases
Photoacoustic imaging can potentially map oxygen saturation (sO2) non-invasively. However, in-vivo human application is challenging due to spectral coloring, which causes a wavelength-dependent fluence attenuation and uncertainty in the estimation of chromophore concentrations deep in tissue. This study compares the performances of two previously proposed methods for spectral coloring compensation
Surface-enhanced Raman scattering (SERS) technology can detect molecular information; Because of its high sensitivity, it is widely used in chemical analysis. In this study discussed the experimental detection of 1,4-diethynylbenzene molecule based on SERS technology. The SERS spectra of 1,4-diethynylbenzene molecule were calculated by Density Functional Theory (DFT) simulation, and the results sh
Due to the large extent of seawater surface over the globe, aerosol particles spend significant time being transported over this type of surface. Therefore, global aerosol circulation is largely impacted by the processes particles undergo during long-range transport overseas. In this study, we investigated submicron aerosol (PM1) chemical composition changes during long-range transport events over
Background: The aim was to develop a theoretical framework for how errors in estimated activities propagate to a dispersion in time-integrated activity in radionuclide-therapy dosimetry and how this affects the comparison of radionuclide-therapy dosimetry schemes. Methods: Formulae for the variance of relative errors of estimated time-integrated activities and relative differences in time-integrat
En kort, Wittgensteininfluerad betraktelse i åminnelse av Karl Dahlstrand.
The effect of β-glucan was tested on microstructure, sensory-specific satiation, subsequent food intake, and in vitro lipid digestion. A high internal phase emulsion was prepared with 75 % milk fat and 25 % whey protein water dispersion, and added as the lipid source to milkshake matrices. Two milkshake variants, one with 1 % β-glucan and the other without fibre, were produced and characterised by
Over the past 50 years there has been an unprecedented increase in pollution globally. Population growth and higher standards of living have resulted in increases in global consumption facilitated by industrialisation and globalisation of goods and services thus resulting in the release of environmental pollutants on a mass scale. This article analyses the effects and consequences of pollution on
Background: Rare variants of the triggering receptor expressed on myeloid cell 2 (TREM2) gene are strong risk factors for Alzheimer’s disease (AD), and drugs targeting the TREM2 protein are being developed. However, it is unknown what the effect of TREM2 variants is on the AD phenotype. Methods: Here we studied a full range of clinical and biomarker measures in a large cohort of TREM2 variant carr
Patients with systemic lupus erythematosus (SLE) face an approximately 30 % risk of thrombosis post-diagnosis. However, there remains significant knowledge gaps regarding causative mechanisms, and there is a lack of specific antithrombotic guidelines. This systematic review aims to examine the existing literature regarding the mechanisms contributing to thrombosis risk in SLE, focusing on five pre
