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The PAM50 gene expression subtypes and the associated risk of recurrence (ROR) score are used to predict the risk of recurrence and the benefits of adjuvant therapy in early-stage breast cancer. The Prosigna assay includes the PAM50 subtypes along with their clinicopathological fea-tures, and is approved for treatment recommendations for adjuvant hormonal therapy and chemotherapy in hormone-recept
Artificial intelligence (AI) has shown promising results in digestive endoscopy, especially in capsule endoscopy (CE). However, some physicians still have some difficulties and fear the advent of this technology. We aimed to evaluate the perceptions and current sentiments toward the use of AI in CE. An online survey questionnaire was sent to an audience of gastroenterologists. In addition, several
The discovery of novel protein biomarkers in melanoma is crucial. Our introduction of formalin-fixed paraffin-embedded (FFPE) tumor protocol provides new opportunities to understand the progression of melanoma and open the possibility to screen thousands of FFPE samples deposited in tumor biobanks and available at hospital pathology departments. In our retrospective biobank pilot study, 90 FFPE sa
The existing information supports the use of this material as described in this safety assessment. Tetrahydro-6-(3-pentenyl)-2H-pyran-2-one was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that tetrahydro-6-(3-pentenyl)-2H-pyran-2-one is not genotoxic.
We present the idea and illustrate potential benefits of having a tool chain of closely related regular, unscreened and screened hybrid exchange–correlation (XC) functionals, all within the consistent formulation of the van der Waals density functional (vdW-DF) method (Hyldgaard et al (2020 J. Phys.: Condens. Matter 32 393001)). Use of this chain of nonempirical XC functionals allows us to map wheWe present the idea and illustrate potential benefits of having a tool chain of closely related regular, unscreened and screened hybrid exchange–correlation (XC) functionals, all within the consistent formulation of the van der Waals density functional (vdW-DF) method (Hyldgaard et al (2020 J. Phys.: Condens. Matter 32 393001)). Use of this chain of nonempirical XC functionals allows us to map whe
We report studies of charge-independent (CI) and charge-dependent (CD)two-particle differential number correlation functions, R2 (Δη,Δ℘), and transverse momentum correlation functions, P2 (Δη,Δ℘) of charged particles produced in Pb-Pb collisions at the LHC centre-of-mass energy √sNN= 2.76 TeV with the UrQMD, AMPT and EPOS models. Model predictions for R2 and P2 correlation functions are presented
We report on the design, fabrication and testing of an ESS Medium Beta prototype cavity made with Large Grain Niobium sheets sliced from an ingot provided by CBMM. The peculiar choices during the fabrication process related to the Large Grain Niobium material are described. We present also the results of the cavity test at cryogenic temperature and the dedicated quench diagnostic.
We present Multipacting studies in ESS Medium-Beta cavities of INFN-LASA design with both simulation and experimental results. The simulation on the ideal cavity shape with both FishPact and MultiPac2.1 codes shows that Multipacting appears in a very small region near equator where the weld seam exists. A simulation with more realistic cavity shape considering the weld seam at cell equators has al
At DESY the Synchrotron Light Source PETRA III offers scientists outstanding opportunities for experiments with hard X-rays of exceptionally high brilliance since 2009. Research activities have been started towards a future upgrade scenario of PETRA III which envisions the conversion of the PETRA ring into a ultra-low emittance hard X-ray radiation source: PETRA IV. The lattice design is aiming fo
In June 2019, Ruddick was considering how to embed the management of a cryptocurrency in the rural Kenyan communities that were to use it. Initially introduced as paper currencies managed by a cooperative of rural residents, moving the currency system onto the blockchain implied a change in the monetary design. The case describes communal structures that organize economic life in rural Kenya, as w
The Open XAL accelerator physics software platform is being developed through an international collaboration among several facilities since 2010. The goal of the collaboration is to establish Open XAL as a multi-purpose software platform supporting a broad range of tool and application development in accelerator physics (Open XAL also ships with a suite of general purpose accelerator applications)
