EGF-like modules in blood coagulation proteins : Ca²+ binding, module interactions, structure and dynamics as studied by NMR spectroscopy
Popular Abstract in Swedish I avhandlingen presenteras resultaten från studier av EGF-moduler från blodkoagulationsproteiner. Dessa studier har utförts med högupplösande kärnmagnetisk resonansspektroskopi. Resultaten av studierna återges i denna populärvetenskapliga sammanfattning. Som bakgrund ges inledningsvis en introduktion till den grundläggande biologin och den teknik som använts i studiernaModules are independently folding protein domains defined on the gene level. The epidermal growth factor-like (EGF) modules are involved in protein-protein interactions and are found in numerous membrane proteins and extracellular proteins, including many proteins of the blood coagulation system. A subset of the EGF modules binds one Ca2+ with an affinity that is often influenced by the neighbouri