The double nucleation mechanism of amyloid β (Aβ) peptide aggregation is retained from buffer to cerebrospinal fluid (CSF) but with reduced rate of all microscopic processes. Here, we used a bottom-up approach to identify retarding factors in CSF. We investigated the Aβ42 fibril formation as a function of time in the absence and presence of apolipoprotein A-I (ApoA-I), recombinant high-density lip

Using new high-resolution data of CO (2-1), H and H obtained with the Northern Extended Millimeter Array (NOEMA) and the Multi-Unit Spectroscopic Explorer (MUSE) at the Very Large Telescope, we have performed a Toomre Q disc stability analysis and studied star formation, gas depletion times and other environmental parameters on sub-kpc scales within the z ∼0 galaxy SDSS J125013.84+073444.5 (LARS 8

Due to excellent thermal performance and application prospects, nanofluids are attracting many researchers to pay more attention to new types of heat transfer fluids. However, previous studies have focused on the effects of nanofluids on thermophysical properties without considering the limitation of dispersion stability in practical applications. Excellent nanofluid stability is judged with the z

Vilken betydelse har det förvetenskapliga för vetenskapen? Vilka betydelser kan det ha? Ska vi som forskare eftersträva största möjliga vetenskaplighet från början till slut? Annorlunda uttryckt: Ska vi metodiskt trycka bort våra förvetenskapliga impulser? Eller ska vi tvärtom välkomna dem? Att följa varje förvetenskaplig impuls, var vi än befinner oss i forskningsprocessen, skulle förmodligen få

The outer part of the skin, stratum corneum, has an architecture of keratin filled cells, the corneocytes, embedded in stacked lipid bilayers. The lamellar structure provides an effective barrier to passive diffusion of small molecules and prevents uncontrolled water loss. In this paper, we present a theoretical model for molecular diffusional transport over an oriented stack of liquid crystalline

148Gd may contribute to around 50% of the dose from inhalation in case of an accident at the European Spallation Source. Methods for its detection have been developed. They rely on biokinetic models predicting activities of the gamma emitters 146Gd (T1/2= 48.3 d) and 153Gd (T1/2= 240.4 d) as tracers in the lungs, urine, and faeces. The optimal choice of model parameters and associated uncertaintie

Radioembolization with 166Ho microspheres is a minimally invasive procedure in which radioactive microspheres are administered directly to liver tumor via the hepatic artery during an interventional radiological procedure. Scout and therapeutic doses of 166Ho were delivered to patients in 2022 and 2023 at VilniusUniversity Hospital Santaros Klinikos. The presented study was aimed at investigating

Autoimmune regulator (AIRE) is a transcriptional regulator expressed in the thymus and necessary for maintaining immunological self-tolerance. Extra-thymic AIRE expression is rare and a role for AIRE in tumor-associated innate immune cells has not yet been established. In this study we show that AIRE is expressed in human pro-tumor neutrophils. In breast cancer, AIRE was primarily located to tumor

The near-drip-line nucleus [Formula Presented] Pr was populated with the reaction [Formula Presented] Mo[Formula Presented] Ca,[Formula Presented] at a beam energy of 175 [Formula Presented] V. Particle-[Formula Presented]-[Formula Presented] coincidences were collected, and the total energy plane gating technique was used to enhance events associated with the [Formula Presented] exit channel. Thi

Lifetimes have been measured in a superdeformed rotational band recently identified in the N = Z nucleus 36Ar. A large low-spin quadrupole deformation (β2=0.46±0.03) is confirmed and a decrease in the collectivity is observed as the high-spin band termination at Iπ=16+ is approached. Detailed comparisons of the experimental B(E2) values with the results of cranked Nilsson-Strutinsky and large-scal

The Theosophical movement which emerged in the late nineteenth century served as an important context through which beliefs, practices, and social networks associated with Asian religion were disseminated in Europe during the early twentieth century. Early Theosophy favored the doctrinal and philosophical dimensions of Asian religion and much of the movement’s activities consisted of the productio

Background and objectives: We focus on the linkages between relocation, new forms of partner cohabitation, and retirement. What are the patterns and trajectories of moving in with a partner in retirement? How do older adults experience different transitions, place attachment, and placemaking when they move in with a partner? Research design and methods: In this qualitative study, 50 persons betwee

Background: Vascular adverse events after collagenase injection for Dupuytren disease are absent in large trials and systematic reviews. The aim of this study is to present a case series of delayed vascular complications after collagenase treatment. Methods: A prospective evaluation of 1181 consecutively treated patients at one orthopedic department identified three patients reporting symptoms of

Background: An adequate future liver remnant (FLR) is fundamental for major liver resections. To achieve sufficient FLR, portal vein embolization (PVE) may be used. The most effective material for PVE has yet to be determined. The aim of this study was to investigate the differences in FLR growth between n-butyl-cyanoacrylate glue (NBCA) and microparticles. Material/methodsa: retrospective study w

BACKGROUND: Observational studies have shown that women with an early menopause are at higher risk of stroke compared with women with a later menopause. However, associations with stroke subtypes are inconsistent, and the causality is unclear. METHODS AND RESULTS: We analyzed data of the UK Biobank and EPIC-CVD (European Prospective Investigation Into Cancer and Nutrition-Cardiovascular Diseases)

Background: Dynamic PET imaging studies provide accurate estimates of specific binding, but also measure the relative tracer delivery (R1), which is a proxy for relative cerebral blood flow (rCBF). Recently, studies suggested that R1 obtained from different tracers could be used interchangeably and is irrespective of target tissue. However, the similarities or differences of R1 obtained from diffe

Objective: Non-invasive identification of motoneuron (MN) activity commonly uses electromyography (EMG). However, surface EMG (sEMG) detects only superficial sources, at less than approximately 10-mm depth. Intramuscular EMG can detect deep sources, but it is limited to sources within a few mm of the detection site. Conversely, ultrasound (US) images have high spatial resolution across the whole m