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Novel subunit in C4b-binding protein required for protein S binding

C4b-binding protein (C4BP) is a multimeric protein with regulatory functions in the complement system. It also interacts with vitamin K-dependent protein S, which is involved in the regulation of the coagulation system. It has been demonstrated that C4BP consists of seven disulfide-linked, identical 70-kDa subunits, which are arranged to give the molecule a spider-like structure. We now have evide

The HIV-1 epidemic in Ethiopia – transmission patterns, antiretroviral drug resistance and treatment outcomes

A comprehensive understanding of local HIV epidemiology is essential for monitoring transmission, designing, implementing, and evaluating HIV intervention strategies. In paper I, we used a total of 1276 HIV-1 subtype C pol sequences and employed state-of-art phylogenetic and phylodynamic tools to describe the molecular epidemiology of HIV in Ethiopia. Our results showed that the HIV epidemic in Et

Effects of pre-injection on ignition, combustion and emissions of spray under engine-like conditions

Large-eddy simulation (LES) of multiple-injection spray combustion under engine-like conditions is performed using a coupled model of an Eulerian stochastic field transported probability density function (ESF T-PDF) and a flamelet generated manifold (FGM). This coupled model allows the use of the T-PDF methods in modeling the interaction of turbulence and chemistry at affordable computational cost

Design of a high-resolution Rayleigh-Taylor experiment with the Crystal Backlighter Imager on the National Ignition Facility

The Rayleigh-Taylor (RT) instability affects a vast range of High Energy Density (HED) length scales, spanning from supernova explosions (1013 m) to inertial confinement fusion (10-6 m). In inertial confinement fusion, the RT instability is known to induce mixing or turbulent transition, which in turn cools the hot spot and hinders ignition. The fine-scale features of the RT instability, which are

Activated protein C resistance and anticoagulant proteins in young adults with central retinal vein occlusion

BACKGROUND: Central retinal vein occlusion is a disease that is most common in old people, and often associated with atherosclerosis, hypertension, diabetes or glaucoma. Since these diseases are much less evident in young people, we wanted to investigate the prevalence of disorders in the most common anticoagulant proteins in a group of young patients with central retinal vein occlusion.METHODS: 3

A Key-Recovery Side-Channel Attack on Classic McEliece Implementations

In this paper, we propose the first key-recovery side-channel attack on Classic McEliece, a KEM finalist in the NIST Post-quantum Cryptography Standardization Project. Our novel idea is to design an attack algorithm where we submit special ciphertexts to the decryption oracle that correspond to cases of single errors. Decoding of such ciphertexts involves only a single entry in a large secret perm

Modeling and simulating the sample complexity of solving LWE using BKW-style algorithms

The Learning with Errors (LWE) problem receives much attention in cryptography, mainly due to its fundamental significance in post-quantum cryptography. Among its solving algorithms, the Blum-Kalai-Wasserman (BKW) algorithm, originally proposed for solving the Learning Parity with Noise (LPN) problem, performs well, especially for certain parameter settings with cryptographic importance. The BKW a

Preferences for redistribution

We survey the literature on preferences for redistribution. We discuss different ways the literature has measured these preferences and review literature on the different determinants of preferences for redistribution. These range from institutions and demographic factors to fairness views and social preferences. Income inequality is, perhaps unsurprisingly, one of the most important determinants

Which architectural style makes an attractive streetscape? Aesthetic preferences among city centre managers

Rational design based on aesthetic principles from the 1930s dominates contemporary architecture and property development, contributing to a homogenous urban landscape. The aim of this paper is to examine how professionals involved in city centre development value different architectural styles. Based on a sample of 109 respondents, measuring the architectural preferences of city centre managers,

The influence of personal and public health and smart applications on biking behavior in South Korea

Bicycling is an important form of active transport that contributes to sustainability mobility as a result of its role in personal and public health and emissions reduction. The significance of which has grown since the COVID-19 pandemic outbreak. However, biking studies have neglected, in theoretical terms, developing an understanding of why consumers bike. Therefore, this research designs and ve

Transgressing purity: Intersectional negotiations of gender identity in Swedish schools

The vulnerability of gender nonconforming young people is all too well documented. Arguably, “trans issues” in schools are not restricted to transphobic comments, and need to be analyzed intersectionally. Guided by Lugones’ discussion of the politics of purity read together with the analysis of cisnormativity, this article draws on interviews with Rakel, Robin and Mika, who were part of a larger s

From the Throes of Anguished Mourning Shi‘i Ritual Lamentation and the Pious Publics of Lebanon

Drawing on a study of Shi‘i ritual lamentation in Lebanon, this article examines how religious actors and pious publics employ literary, recitational, theatrical, and socio-technological methods to cultivate imaginal engagements with the other-worldly. These methods are analyzed, demonstrating how they locate pious Shi‘is in religious meta-narratives that transcend the linearity of time, taking pl

Interventions on the politics of governing the “ungovernable”

This intervention seeks to challenge the notion that ungovernable people and places are aberrations to theorizations of governance. By spatializing and grounding theory through ethnographic, multi-sited and actor-focused inquiry, we investigate the techniques and practices of governing territories and people that are deployed in four sites in the Middle East and North Africa. We highlight the impa

Relativistic radial electron density functions and natural orbitals from GRASP2018

A new module, RDENSITY, of the GRASP2018 package [1] is presented for evaluating the radial electron density function of an atomic state described by a multiconfiguration Dirac-Hartree-Fock or configuration interaction wave function in the fully relativistic scheme. The present module is the relativistic version of DENSITY [2] that was developed for the ATSP2K package [3]. The calculation of the s