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In this study, soil cores (0–20 cm) were collected at 45 sites located within a 30-km radius zone around the Belarusian nuclear power plant (BelNPP) in 2019 before its commissioning. Activity of gamma-emitting radionuclides was measured in the samples using HPGe detectors. The study revealed low levels of 137Cs in the soil: the weighted average dry weight (d.w.) activity concentration (ACw) varied
OBJECTIVE: Avacopan (AVAC), an oral selective C5a receptor inhibitor, has been approved for treatment in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Outside randomized controlled studies, real-world data are scarce. The aim of this study was to provide further insight into the clinical experience of AVAC.METHOD: We analysed data from 16 patients with severe AAV include
OBJECTIVE: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are chronic, relapsing inflammatory diseases, yet reliable biomarkers for detecting relapse and organ involvement remain limited. This study aimed to identify plasma protein biomarkers that distinguish active disease from remission and to explore markers associated with lung and kidney involvement.METHODS: Plasma
AIMS: We aimed to investigate if non-invasive pressure-volume (PV) loop variables by cardiovascular magnetic resonance (CMR) are associated with all-cause mortality or heart failure compared to mean arterial blood pressure (MAP), left ventricular ejection fraction (LVEF), and stroke volume (SV) in patients with revascularized ST-elevation myocardial infarction (STEMI).METHODS AND RESULTS: A total
BackgroundNearly 10% of the global population living with dementia resides in South Asia, a region of over two billion people with limited diagnostic and care resources. Clinicians require accessible, flexible, and contextually relevant training to improve dementia care in frontline settings.AimTo develop, pilot, and implement a multi-modal, interactive, hybrid training program to improve clinicia
IMPORTANCE: Human papillomavirus (HPV)-related cancers cause substantial morbidity and mortality. People with HIV (PWH) and solid organ transplant recipients (SOTRs) are at heightened risk due to impaired immune function, but direct comparisons of these groups within the same population are limited; understanding the relative risk and contributing factors is essential for targeted prevention and s
Muon spin rotation (μ+SR) was used to investigate the magnetic properties of cobalt-intercalated 2H-NbSe2 (Co1/4NbSe2). Co1/4NbSe2 is predicted to be an altermagnet, and while neutron diffraction has proposed its magnetic structure, the microscopic details of this remain unclear. Therefore, a local probe investigation of the magnetism in Co1/4NbSe2 is essential. Our results reveal a sharp second-o
Laminar burning velocities (SL) of 2-butanone + air mixtures were measured using the heat flux method at atmospheric pressure over unburnt temperatures of 298–343 K and equivalence ratios of 0.7–1.4. The consistency among the present measurements, literature data, and model predictions was evaluated by means of the temperature and pressure dependences of SL. It was found that the present measureme
Epigenetic modifications influence gene expression and contribute to type 2 diabetes (T2D), but establishing causality requires targeted modulation of specific genes. CRISPR-dCas9-based tools offer this potential, yet β-cells are notoriously difficult to transfect, and efficient, non-viral delivery methods are lacking. Here, we developed nanopore-mediated electroporation to deliver a CRISPR interf
Human single-strand-selective monofunctional uracil DNA glycosylase 1 (hSMUG1) removes uracil, 5-hydroxymethyluracil (5hmU) and 5-fluorouracil (5FU) from DNA, thereby initiating the base excision repair (BER) process. hSMUG1 is important for maintaining genomic integrity and plays a significant role in cancer biology. Here, we present the structures of hSMUG1, including complexes with products (ur
Background: Frailty represents a state of compromised ability to cope with environmental stressors and is associated with negative health-related outcomes in older adults. The study objective is to investigate the prevalence and whether frailty associates with negative health-related outcomes in middle-aged adults. Methods: Data were sourced from three 2-year cycles of NHANES surveys and combined
Background Increased airflow is reported as helpful in reducing the sensation of breathlessness. This systematic review aimed to assess the effectiveness of airflow on breathlessness (primary outcome, measured using a validated tool at rest or during exercise) and health-related quality of life (secondary outcome) in people with serious respiratory illness. Methods We searched Ovid MEDLINE, Embase
Accurate mapping of earthquake-damaged buildings is essential for rapid post-disaster assessment and urban recovery planning. Very high-resolution (VHR) satellite imagery enables large-scale geospatial damage detection; however, conventional convolutional neural networks (CNNs) often struggle to model complex spatial dependencies and nonlinear damage patterns efficiently. To address these limitati
BackgroundRight ventricular (RV) failure is a key determinant of outcome in precapillary pulmonary hypertension (PHprecap). Contemporary four-strata risk assessment incorporates functional capacity and NT-proBNP, yet the relationship between these and RV function remains unclear. We therefore examined these associations in PHprecap.Methods and resultsPatients with PHprecap (n=49; 69% women, median
Aims: This study describes the Norwegian Sports Membership Database (NSMD), assesses its coverage, and develops definitions of active sports memberships. Methods: We validated the coverage of the NSMD, a database capturing individual-level sports memberships among people aged 10–70 years between 2015 and 2024. We compared yearly membership counts in the NSMD with figures from official reports from
BackgroundPost-transplant diabetes mellitus (PTDM) is common after orthotopic heart transplantation (OHT), but its long-term impact on myocardial function is unclear. We aimed to evaluate the effects of PTDM on left ventricular (LV) systolic function.MethodsWe prospectively studied 102 OHT recipients with echocardiographic follow-up at 1-, 3-, and 5-year post-transplant. Patients were classified a
Background: Poor self-reported sleep quality is associated with cognitive impairment. Alzheimer’s disease (AD) patients present sleep disruptions decades before they start to decline clinically. Similarly, amyloid-β (Aβ) starts accumulating during the preclinical phase of the disease. This study investigated associations between self-reported sleep quality and Aβ burden longitudinally in clinicall
