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We would like to congratulate six researchers at Lund University Diabetes Centre, who have been awarded research grants within medicine and health by the Swedish Research Council (VR). The six researchers are affiliated with Excellence of Diabetes Research in Sweden (EXODIAB), which is a strategic research area within diabetes at Lund University.Helena Elding Larsson, professor of autoimmune disea

https://www.ludc.lu.se/article/six-ludc-researchers-receive-medicine-and-health-grants-vr - 2025-11-15

An international team of researchers has investigated whether oral insulin can prevent early signs of type 1 diabetes and clinical diagnosis in children with an increased risk of developing the disease. Although treatment with oral insulin could not prevent development of diabetes-related autoantibodies, oral insulin delayed the rate of disease progression in children who developed such autoantibo

https://www.ludc.lu.se/article/oral-insulin-delayed-onset-type-1-diabetes-some-children-increased-risk-disease - 2025-11-15

Social and economic factors have led to a dramatic rise in type 2 diabetes and obesity around the world. In a review in Science, Mark McCarthy, professor at the University of Oxford, UK, and Paul Franks, professor at Lund University, Sweden, examine the knowledge of the actual causes and the interplay between genetics and lifestyle factors. By studying how our genes express themselves in response

https://www.ludc.lu.se/article/review-type-2-diabetes-and-obesity-what-do-we-really-know - 2025-11-15

Lund University Diabetes Centre has entered into a collaboration with the Regeneron Genetics Center LLC (RGC) and the University of Helsinki involving exome-sequencing and whole genome array genotyping of greater than 9,000 individuals. The collaboration will involve the largest sequencing study in diabetes families to date and aims to help generate knowledge about how to predict diabetes, causes

https://www.ludc.lu.se/article/lund-initiates-genetic-sequencing-study-diabetes-families-provide-new-insights-what-causes-disease - 2025-11-15

Research from Lund University in Sweden can explain why type 2 diabetes is inherited to a greater extent from an individual’s mother. The heredity of a previously known risk gene, THADA, has proven to be dominant if it comes from the mother, whereas it has little or no effect on the child’s risk of disease if it originates from the father.
“Our research contributes to increased knowledge about the

https://www.ludc.lu.se/article/thada-new-findings-role-mother-type-2-diabetes - 2025-11-15

A new experimental and clinical study from Lund University in Sweden shows that the sleep hormone melatonin impairs insulin secretion in people with a common gene variant.

“This could explain why the risk of type 2 diabetes is greater among, for instance, overnight workers or people with sleeping disorders”, says Professor Hindrik Mulder who is responsible for the study. Melatonin is a naturally

https://www.ludc.lu.se/article/new-findings-explain-connection-between-melatonin-and-type-2-diabetes - 2025-11-15

One in three people with diabetes will face some form of renal impairment in the course of their lives. Studies conducted by researchers at the Lund University Diabetes Centre may lead to the development of an entirely new principle for treating type 2 diabetes and preventing kidney damage in the future. Previous analyses have not been able to identify genetic causes as to why some people have a h

https://www.ludc.lu.se/article/new-findings-can-lead-new-principle-treating-diabetic-kidney-damage - 2025-11-15

One in three people with diabetes will face some form of renal impairment in the course of their lives. Studies conducted by researchers at the Lund University Diabetes Centre may lead to the development of an entirely new principle for treating type 2 diabetes and preventing kidney damage in the future. Previous analyses have not been able to identify genetic causes as to why some people have a h

https://www.ludc.lu.se/article/new-findings-can-lead-new-principle-treating-diabetic-kidney-damage-0 - 2025-11-15

The European Research Council makes a large investment in diabetes research. A project led by Professor Paul Franks at Lund University Diabetes Centre is to develop methods that can be used in the design of preventive treatment for type 2 diabetes and cardiovascular disease. - Through this project we will use functional genomics and epidemiology to identify novel molecular mechanisms that underlie

https://www.ludc.lu.se/article/focus-personalized-treatment-type-2-diabetes-and-cardiovascular-disease - 2025-11-15

Social and economic factors have led to a dramatic rise in type 2 diabetes and obesity around the world. In a review in Science, Mark McCarthy, professor at the University of Oxford, UK, and Paul Franks, professor at Lund University, Sweden, examine the knowledge of the actual causes and the interplay between genetics and lifestyle factors. By studying how our genes express themselves in response

https://www.ludc.lu.se/article/type-2-diabetes-and-obesity-what-do-we-really-know - 2025-11-15

Countries with the highest burden of maternal and newborn deaths and stillbirths often have little information on these deaths. Since over 81% of births worldwide now occur in facilities, using routine facility data could reduce this data gap. We assessed the availability, quality, and utility of routine labour and delivery ward register data in five hospitals in Bangladesh, Nepal, and Tanzania. T

https://www.lupop.lu.se/article/labour-and-delivery-ward-register-data-availability-quality-and-utility-every-newborn-birth - 2025-11-15

We reweighted the Malmö Diet and Cancer (MDC) study based on population register data on background variables, including socio-demographics and hospital admissions for both participants and the background population. Following individuals from baseline in 1991-1996 and at most until 2016, we studied mortality (all-cause, cancer, and CVD), incidences (cancer and CVD), and associations between these

https://www.lupop.lu.se/article/can-validity-cohort-be-improved-reweighting-based-register-data-evidence-swedish-mdc-study - 2025-11-15

A project jointly conducted by the Nordic national statistical institutes and funded by NordForsk was initiated in 2015. The project, Nordic Microdata Access Network (NordMAN), seeks to establish a single pan-Nordic solution to facilitate researchers' access to the Nordic metadata compiled for statistical purposes, and to provide an overview of the existing Nordic registers. The project’s common N

https://www.lupop.lu.se/article/nordman-facilitates-researchers-access-nordic-microdata-and-provides-metadata-existing-nordic - 2025-11-15

Data from population-based cancer registries are often used to compare cancer survival between countries or regions. The ICBP SURVMARK-2 study is an international partnership aiming to quantify and explore the reasons behind survival differences across high-income countries. However, the magnitude and relevance of differences in cancer survival between countries have been questioned, as it is argu

https://www.lupop.lu.se/article/exploring-impact-cancer-registry-completeness-international-cancer-survival-differences-simulation - 2025-11-15

We propose combining population-based register data with a nested clinical cohort to correct misclassification and unmeasured confounding through probabilistic quantification of bias. We have illustrated this approach by estimating the association between knee osteoarthritis and mortality. We used the Swedish Population Register to include all persons resident in the Skåne region in 2008 and asses

https://www.lupop.lu.se/article/probabilistic-quantification-bias-combine-strengths-population-based-register-data-and-clinical-0 - 2025-11-15

Based on discharge summaries and brain imaging reports, we estimated the positive predictive value (PPV) of a first-ever diagnosis code for ICH (ICD-10, code I61) for all patients in the Region of Southern Denmark (1.2 million) during 2009– 2017 according to either DNPR or DSR. We estimated PPVs for any non-traumatic ICH (a-ICH) and spontaneous ICH (s-ICH) alone (ie, without underlying structural

https://www.lupop.lu.se/article/validity-intracerebral-hemorrhage-diagnoses-danish-patient-registry-and-danish-stroke-registry - 2025-11-15

Participants are members of the Maccabi Health Services, 40–65 years of age, with exquisitely detailed laboratory, medical diagnoses and medication data available in the Maccabi electronic medical records since 1998. Data collected through IRAP include genetic, sociodemographic, cognitive, brain imaging, lifestyle, and health-related characteristics at baseline and every three years thereafter. Re

https://www.lupop.lu.se/article/israel-registry-alzheimers-prevention-irap-study-design-and-baseline-characteristics - 2025-11-15

Large prospective cohort studies may offer an opportunity to study the etiology and natural history of rare cancers. Cancer diagnoses in observational cohort studies are often self-reported. Little information exists on the validity of self-reported cancer diagnosis, especially rare cancers, in Canada. This study evaluated the validity of self-reported cancer diagnosis in Alberta’s Tomorrow Projec

https://www.lupop.lu.se/article/importance-cancer-registry-linkage-studying-rare-cancers-prospective-cohorts - 2025-11-15

Acquisition of data on clinical performance is essential to improve outcomes in surgery. Large, national datasets allow hospitals to monitor events involving patient safety, complications, and benchmark against peer hospitals and facilitate quality improvement (QI) development. Although clinical datasets are often preferable, administrative data also have potential for actionable QI. Hospitals sho

https://www.lupop.lu.se/article/administrative-and-registry-databases-patient-safety-tracking-and-quality-improvement - 2025-11-15

A nationwide random sample of 500 children (6–17 years) diagnosed with depression between 1996 and 2016 was identified in the DPCRR. Psychiatric hospital records were reviewed and rated using an online checklist. The primary outcome was whether depressive symptoms and functional impairment documented in hospital records justified a depressive disorder diagnosis based on ICD‐10 or DSM‐5 diagnostic

https://www.lupop.lu.se/article/validity-child-and-adolescent-depression-diagnoses-danish-psychiatric-central-research-register - 2025-11-15