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Development of a multinational registry of pediatric deceased organ donation activity

Published 11 November 2019 There are no currently agreed upon international standards for reporting of pediatric deceased organ donation activity. This leads to difficulty in comparisons between jurisdictions for both researchers and policy stakeholders. The goal of this project was to develop and test a standardized registry for pediatric deceased donation activity. New publication in Pediatric T

https://www.lupop.lu.se/article/development-multinational-registry-pediatric-deceased-organ-donation-activity - 2025-05-09

Commonly used estimates of the genetic contribution to disease are subject to the same fallacies as bad luck estimates

Published 12 November 2019 The scientific debate following the initial formulation of the “bad luck” hypothesis in cancer development highlighted how measures based on analysis of variance are inappropriately used for risk communication. The notion of “explained” variance is not only used to quantify randomness, but also to quantify genetic and environmental contribution to disease in heritability

https://www.lupop.lu.se/article/commonly-used-estimates-genetic-contribution-disease-are-subject-same-fallacies-bad-luck-estimates - 2025-05-09

Whole-genome sequencing of triple-negative breast cancers in a population-based clinical study

Published 13 November 2019 Whole-genome sequencing (WGS) brings comprehensive insights to cancer genome interpretation. To explore the clinical value of WGS, we sequenced 254 triple-negative breast cancers (TNBCs) for which associated treatment and outcome data were collected between 2010 and 2015 via the population-based Sweden Cancerome Analysis Network–Breast (SCAN-B) project (ClinicalTrials.go

https://www.lupop.lu.se/article/whole-genome-sequencing-triple-negative-breast-cancers-population-based-clinical-study - 2025-05-09

Population-Based Observational Studies in Oncology: Proceed With Caution

Published 14 November 2019 A principle goal of research in Oncology is to determine the optimal treatment for our patients. This often takes the form of comparing 2 existing therapies to one another to determine which is superior, or to introduce a new therapy and determine if it is superior or noninferior to the existing standard of care. New publication in Seminars in Radiation Oncology

https://www.lupop.lu.se/article/population-based-observational-studies-oncology-proceed-caution - 2025-05-09

Validation of diagnosis codes to identify side of colon in an electronic health record registry

Published 15 November 2019 ICD codes are a highly reliable indicator of tumor location when the specific location code is entered in the EHR. However, non-specific side of colon ICD codes are present for a sizable minority of patients, and structured data alone may not be adequate to support testing of some research hypotheses. New publication in BMC Medical Research Methodology

https://www.lupop.lu.se/article/validation-diagnosis-codes-identify-side-colon-electronic-health-record-registry - 2025-05-09

Key concepts and principles for design and critical interpretation of Nordic register-based studies

Published 12 November 2019 This two-week course is divided into two separate course weeks. The course will be arranged as a retreat somewhere in Sweden. Travel costs and accommodation will be covered in relation to the educational activities. The target group is doctoral students (and those who have recently completed their doctoral education) involved in register-based research within their resea

https://www.lupop.lu.se/article/key-concepts-and-principles-design-and-critical-interpretation-nordic-register-based-studies-0 - 2025-05-09

A critical reflection on the grading of the certainty of evidence in umbrella reviews

Published 19 November 2019 In conclusion, umbrella reviews provide a comprehensive overview of a specific research topic and are very helpful tools to evaluate the certainty of evidence. These systematic overviews are helpful for the translation of research findings into recommendations, and also for identifying new research directions. New publication in European Journal of Epidemiology

https://www.lupop.lu.se/article/critical-reflection-grading-certainty-evidence-umbrella-reviews - 2025-05-09

Chronic pain: a review of its epidemiology and associated factors in population-based studies

Published 20 November 2019 Chronic pain is a common, complex, and distressing problem that has a profound impact on individuals and society. It frequently presents as a result of a disease or an injury; however, it is not merely an accompanying symptom, but rather a separate condition in its own right, with its own medical definition and taxonomy. New publication in British Journal of Anaesthesia

https://www.lupop.lu.se/article/chronic-pain-review-its-epidemiology-and-associated-factors-population-based-studies - 2025-05-09

Doing more of less: what registry data tell us about death in PICU

Published 21 November 2019 The development of paediatric critical care registries, a term we take to include national audits and research databases, has been instrumental in helping us understand the state of children’s critical care and thereby provide a platform for future improvement. Comprehensive datasets enable monitoring of activity and outcomes for audit, safety and service planning. New p

https://www.lupop.lu.se/article/doing-more-less-what-registry-data-tell-us-about-death-picu - 2025-05-09

Professor with specific responsibilities in epidemiology and demography

Published 9 April 2019 A position as professor with specific responsibilities in epidemiology and demography is vacant for a period of 5 years with possibility of extension for another 3 years at the Research Unit of Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark (SDU), Odense. Read more here.

https://www.lupop.lu.se/article/professor-specific-responsibilities-epidemiology-and-demography - 2025-05-09

The long and winding road to causality

Published 11 April 2019 Epidemiologists face two fundamental and interrelated problems when judging causality: knowledge is fallible, and studies are imperfect. In medicine, this will always leave a degree of uncertainty in scientific judgements. From an epistemological point of view, even randomized trials cannot be regarded as the ultimate proof to establish a causal relation. Given this inheren

https://www.lupop.lu.se/article/long-and-winding-road-causality - 2025-05-09

Panel debate: Plan S and Open Access – the way to go for Swedish researchers?

Published 12 April 2019 Traditional publishing versus sharing results without restrictions has become a fundamental question that involves many different stakeholders, including scientists, librarians, publishers, and research funding organizations. See a panel of international experts discuss the matter. Read more here.

https://www.lupop.lu.se/article/panel-debate-plan-s-and-open-access-way-go-swedish-researchers - 2025-05-09