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Researchers at Lund University are developing a new type of gene therapy that reprograms cancer cells within tumors into immune cells that can help the immune system fight cancer. Their approach, now published in the journal Science, could lead to more effective treatments for hard-to-treat cancers. Reprogramming Cancer Cells into Immune Cells Earlier research by the team showed that three special

https://www.medicine.lu.se/article/researchers-reprogram-tumor-cells-cancer-fighting-immune-cells-living-beings - 2025-09-27

By describing his research as a battle between good and evil and likening himself to a hacker who attacks cancer cells to make them kind, PhD student Luís Oliveira took home the win in this year's Research Grand Prix. It is a competition in presentation technique for researchers, and it was held in front of an audience of almost 400 students at Helsingborg's Stadsteater on 1 October. In November,

https://www.medicine.lu.se/article/he-won-regional-heat-researcher-grand-prix-now-heading-national-contest-stockholm - 2025-09-27

For the first time, researchers have linked specific frequent defects in sperm to risk of pregnancy complications and negative impacts on the health of the baby. The study from Lund University in Sweden shows that high proportion of father’s spermatozoa possessing DNA strand breaks is associated with doubled risk of preeclampsia in women who have become pregnant by IVF. It also increases the risk

https://www.medicine.lu.se/article/defective-sperm-doubles-risk-preeclampsia - 2025-09-27

It has previously been difficult to identify DNA mutations in sperm, as these changes are rare, and most sequencing techniques have a large margin of error. Now a research study led from Lund University, have conducted a pilot study in which they examined sperm DNA and it’s similarity to mutations in children, using the advanced technique called duplex sequencing. Nearly 80 percent of all new muta

https://www.medicine.lu.se/article/new-method-enables-identification-mutations-sperm - 2025-09-27

A career in science was not on the map for Kári Stefánsson, who aspired to become a writer. But life took another road and the return to Iceland almost three decades ago marked the start of a journey that would revolutionize genetics. Meet this year’s receiver of the Eric K. Fernström Award. "Genetics is the only way to systematically study human nature. So we came to the conclusion that the way t

https://www.medicine.lu.se/article/success-makes-it-difficult-quit - 2025-09-27

Obesity is a common cause of diabetes, heart disease and early death, but risk differs greatly from one person to the next. In work led by researchers at Lund University in Sweden as part of the Innovative Medicine Initiative project SOPHIA, a pioneering clinical risk prediction algorithm has been developed that splits obesity into 5 separate diagnostic profiles each with contrasting health conseq

https://www.medicine.lu.se/article/new-precision-medicine-approach-helps-detect-subgroups-people-obesity-high-risk-diabetes-and-heart - 2025-09-27

Diabetes researcher Joao Duarte specialices in studying what happens in the brain in diabetes. In his research, he is also investigating how diet changes can improve brain function in connection with diabetes. He will be awarded this year's Medeon stipend on the World Diabetes Day Skåne event in Malmö on November 14. "I hope that my research can contribute to an increased awareness of the importan

https://www.medicine.lu.se/article/praised-research-diabetes-and-dementia - 2025-09-27

In 2025, children within the TEDDY study will submit their final samples at research clinics in Sweden, Finland, Germany and the United States. The international study has provided a lot of new knowledge about type 1 diabetes and how the disease develops. Analysis of the samples will continue with the aim of preventing the disease. Sweden and Finland are the two top countries for incidence rates o

https://www.medicine.lu.se/article/new-knowledge-about-type-1-diabetes-large-scale-teddy-study-will-soon-be-completed - 2025-09-27

Malin Parmar, professor of cellular neuroscience, along with three researchers in Italy and Denmark, has been awarded the prestigious ERC Synergy Grant worth EUR 10 million. The four researchers aim to develop custom-made neurons from stem cells for cell therapies to treat Parkinson’s or Huntington’s disease. Congratulations!“Thank you, it feels really fun and exciting for many reasons! One reason

https://www.medicine.lu.se/article/erc-synergy-grant-awarded-development-custom-made-stem-cell-therapies - 2025-09-27

A research team at Lund University in Sweden has discovered a certain type of cells – foam cells – in patients with the aggressive brain tumour glioblastoma. It has been shown how these cells accelerate the cancer’s growth and that this can be successfully inhibited using a drug developed for arteriosclerosis. Glioblastoma affects around 500 Swedes every year and is the most common and most aggres

https://www.medicine.lu.se/article/foam-cells-brain-tumours - 2025-09-27

After 20 years of research on gene therapy and the rare blood disease, Diamond-Blackfan Anemia, DBA, researcher Johan Flygare had reached a point where he and his colleagues had done everything they could in the lab. Even though they had proof of concept their gene therapy would work, engaging companies had been difficult. Then, in 2021, he received an e-mail. LONGREAD. The message came from Ameri

https://www.medicine.lu.se/article/science-start-developing-gene-therapy-rare-blood-disorder - 2025-09-27

Bioelectronics research and development of implants made of electrically conductive materials for disease treatment is advancing rapidly. However, bioelectronic treatment is not without complications. Researchers at Lund University in Sweden have taken another step forward by developing a refined method to create detailed and tissue-friendly bioelectronics. In a study published in Advanced Science

https://www.medicine.lu.se/article/using-light-create-bioelectronics-inside-body - 2025-09-27

It has been a year ago since bacteria from war-wounded at hospitals in Ukraine were analysed. The study, which attracted a lot of attention, showed that some of the bacteria types had total resistance to antibiotics. Now, the same researchers have examined the infectiousness of the bacteria. "The bacterium 'Klebsiella pneumoniae', which is resistant to all antibiotics, is also particularly aggress

https://www.medicine.lu.se/article/pandrug-resistant-bacteria-war-ukraine-are-extremely-pathogenic - 2025-09-27

An international team of researchers, led by scientists at Lund University, has uncovered how magnesium enters mitochondria. Magnesium is a vital mineral that plays a key role in numerous biological processes in the body. Among other functions, it is crucial for the mitochondria—the power plants of our cells—to produce and utilize ATP, the body’s primary energy molecule. When mitochondrial functio

https://www.medicine.lu.se/article/auto-regulating-channels-supply-our-cells-magnesium - 2025-09-27

A team of international researchers led by Professor Johan Jakobsson at Lund University has secured a 52 million SEK grant from the Aligning Science Across Parkinson’s (ASAP) initiative, in partnership with the Michael J Fox Foundation to investigate how mobile genetic elements —commonly referred to as "jumping genes"—contribute to neuroinflammation and the progression of Parkinson’s disease. Jump

https://www.medicine.lu.se/article/52-million-sek-goes-uncovering-genetic-drivers-parkinsons-disease-0 - 2025-09-27

People with type 2 diabetes have a higher risk of developing cardiovascular disease and dying prematurely due to atherosclerosis. A research team at Lund University in Sweden has now identified molecular mechanisms that may explain the increased risk. Their discovery may lead to more accurate treatments for patients with atherosclerosis and type 2 diabetes in the future. People with type 2 diabete

https://www.medicine.lu.se/article/new-explanation-dangerous-atherosclerotic-plaques-type-2-diabetes - 2025-09-27

An observational study from Lund University in Sweden examining sugar consumption has attracted considerable international attention. The study shows that sweetened beverages have a greater negative impact on health than other sources of sugar. They significantly increased the risk of ischaemic stroke, heart failure, atrial fibrillation and abdominal aortic aneurysm. Of the 70,000 Swedes who took

https://www.medicine.lu.se/article/questions-and-answers-lund-university-sugar-study - 2025-09-27

Nicholas Leigh came from the United States to Sweden and Lund University four years ago. In his research, he focuses on salamanders and how they can recreate body parts such as legs, tails and even components of the heart. It was the ability of moose to grow new antlers after shedding that first sparked Nicholas Leigh’s interest in regenerative research. For practical reasons, the choice fell on s

https://www.medicine.lu.se/article/seeking-shutdown-button-cancer - 2025-09-27

In 2022, Sweden became the first country in the world to allow body checking in women's ice hockey. Major hockey nations are now following Lund University's research on the consequences of tougher plays on the ice. A first study shows that almost nine out of ten players in the Swedish women's hockey league are in favour of body checking – regardless of their own size. “We found that interesting. T

https://www.medicine.lu.se/article/swedish-female-ice-hockey-players-favour-body-checking - 2025-09-27

Elite ice hockey players with a history of concussion report heightened mental health symptoms, according to a new study from Lund University in Sweden. In addition, one in five female hockey players suffered symptoms of burnout, and both sexes reported an alcohol consumption at a risk-level. The researchers based their study on Sweden’s two highest hockey divisions for men – the SHL and Hockeyall

https://www.medicine.lu.se/article/professional-ice-hockey-depressive-symptoms-and-burnout-linked-more-concussions - 2025-09-27