Background: General Practitioners (GPs) are responsible for primary prescribing decisions in most settings. Elderly patients living in Advanced Care Facilities (ACFs) often have significant co-morbidities to consider when selecting an appropriate drug therapy. Careful assessment is required when considering appropriate medication use in frail older patients as they have multiple diseases and thus

Background: Detection of atrial fibrillation after ischemic stroke is challenging due to its paroxysmal nature. We aimed to assess predictors of paroxysmal atrial fibrillation using non-invasive surface ECG and transthoracic echocardiography to select candidates for atrial fibrillation screening. Methods: Ischemic stroke patients without documented atrial fibrillation (n = 110, 67 ± 10 years, 40 f

Purpose To study prevalence of diabetic retinopathy (DR) at diagnosis (DRAD) and to estimate contributing risk by sociodemographic, cardiovascular and metabolic characteristics present in patients recently diagnosed with type 2 diabetes (T2D) or latent autoimmune diabetes in the adult (LADA). Methods Patients (n = 2174) recently diagnosed T2D (93%) or LADA (7%) were included upon arrival for their

Approximately 80%-90% of all fire-related fatalities take place in residential occupancies. The risk groups are well known, but the effectiveness of different measures has been less investigated. In this article, fire investigations from 144 unintentional fatal residential fires have been systematically analyzed and technical measures that would have been effective in preventing each fatality have

Background: Inositol trispyrophosphate (ITPP) has been shown to reduce tumour growth in different animal cancer models, as well as of human U87 glioma cells grafted onto chick chorioallantoic membrane (CAM). The aim of this study was to establish whether ITPP crosses the blood-brain barrier and whether it halts the growth of RG2 glioblastoma tumour. Materials and Methods: A model comprising of Fis

This study addresses the enduring problem of the mismatch between firms' offerings and consumers' desires. It combines the general framework of modernity theory with the concept of regimes and uses the food area as the empirical context. Our cultural analytical study of consumers' and firms' articulation of values of food and meal demonstrates that firms are largely entrenched in the modern era, c

Secretagogin is a calcium-sensor protein with six EF-hands. It is widely expressed in neurons and neuro-endocrine cells of a broad range of vertebrates including mammals, fishes and amphibia. The protein plays a role in secretion and interacts with several vesicle-associated proteins. In this work, we have studied the contribution of calcium binding and disulfide-bond formation to the stability of

Integration of evolutionary and developmental biology has stimulated novel insights on the origins and maintenance of phenotypic variation. For instance, phenotypic accommodation predicts that trait covariance originates via a novel developmental input caused by genetic change in one trait, but not the other. Darwin provided a striking example of this process in the ‘lop-eared’ rabbit by demonstra

This paper presents an existence theory for solitary waves at the interface between a thin ice sheet (modelled using the Cosserat theory of hyperelastic shells) and an ideal fluid (of finite depth and in irrotational motion) for sufficiently large values of a dimensionless parameter γ. We establish the existence of a minimiser of the wave energy E subject to the constraint I=2μ, where I is the hor

Ukrainian president Viktor Iushchenko's posthumous designation of Roman Shukhevych (1907-1950), the supreme commander of the Ukrainian Insurgent Army (upa) as a Hero of Ukraine in 2007 triggered intense, and polarized debates in Ukraine and abroad, about Second World War-era Ukrainian nationalism and its place in history. Particularly sensitive are Roman Shukhevych's whereabouts in 1940-1943, when

Complement resistance is an important virulence trait of Yersinia enterocolitica (Ye). The predominant virulence factor expressed by Ye is Yersinia adhesin A (YadA), which enables bacterial attachment to host cells and extracellular matrix and additionally allows the acquisition of soluble serum factors. The serum glycoprotein vitronectin (Vn) acts as an inhibitory regulator of the terminal comple