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Rate Limiting Factors For Protein Folding.

Popular Abstract in Swedish Proteiner är stora kedjelika molekyler som syntetiseras i cellen med utgångspunkt från arvsmassan, DNA. I alla organismer har proteinerna en mängd uppgifter som kan sträcka sig allt ifrån att vara byggnadsmaterial i senor och bindväv till att fungera som avancerade molekylära maskiner i organismens energiomsättning. I stor utsträckning reglerar olika proteiner också bilAbstract. This thesis describes factors that are rate limiting for the folding of two small proteins, U1A and CI2 which fold without accumulating intermediates. The [GdnHCl] dependencies of the unfolding- and refolding kinetics of U1A display downward curvatures. However, as the curvatures are precisely matched and no indications of formation of partially structured intermediates are seen, the fol

The Design of an Energy Efficient Highly Glazed Office Building

Many modern office buildings have highly glazed facades. Their energy efficiency and indoor climate is, however, being questioned. Therefore, when a modern office building (new construction) with larger glazing areas was planned, an investigation was carried out to determine the possibilities to: - efficiently use the increased access to daylight and thereby reduce the use of electricity for light

Ritual Time and Space: A Liminal Age and Religious Consciousness

The article discusses if it is possible to bring Victor Turner’s work on liminality and ritual together with Roy Rappaport’s thought-provoking ritual theory and approach the contemporary ecological crisis in new ways. Specifically, it examine if we creatively can employ Turner’s concept of liminality and his understanding of a liminal passage as a metaphorical vision of re-embedding humanity withi

Sesquiterpene synthases in Artemisia annua: Cloning, Expression, and Characterisation of the Recombinant Enzymes

Popular Abstract in Swedish Extrakt från växten Artemisia annua har dokumenterats för sina anti-malaria egenskaper. Substansen är en mycket effektiv medicin mot malaria och hjälper även mot de former där multi-resistens utvecklats.1979 presenterades strukturen på den aktiva substansen. Den benämns artemisinin och är uppbygd av femton kol innehållandes en peroxid-brygga (två syre kopplade till varaPlants produce a multitude of different compounds that may have biotic effects. Artemisia annua, produces a compound used as a drug against multi-drug-resistant strains of Plasmodium falciparum, the parasite causing malaria. The compound, artemisinin, is a sesquiterpene and is an essential component for the production of artemisinin drugs against malaria. In a first critical step of the biosynthes

Polysemy or generality? Mu

This chapter proposes a conception of lexical meaning as use-potential, in contrast to prevailing atomistic and reificational views. The issues are illustrated on the example of spatial expressions, pre-eminently prepositions. It is argued that the dichotomy between polysemy and semantic generality is a false one, with expressions occupying points on a continuum from full homonymy to full monosemy

Bacterial and fungal growth in soil: The effect of temperature and substrate addition

Bacteria and fungi are the main agents in decomposition of soil organic matter. Their activity is determined by the availability and quality of substrate, especially its content of carbon, but also nitrogen and phosphorus. Other environmental factors, which affect the activity of the microbial community in soil, are temperature, moisture and pH. In this thesis the focus was on how temperature and

Effects of cobalt and humic substances on the growth of bloom-forming marine phytoplankton

In this thesis, the importance of cobalt and humic substances of terrestrial origin for the growth of some bloom-forming marine phytoplankton species is examined. Cobalt (Co) is considered an essential and potentially limiting trace metal for phytoplankton growth and is needed for the synthesis of vitamin B12. Since Co can be mobilised from soils at low pH values, acidification may have led to an

Head and Neck Cancer: Studies on microvessel density, radiation response and FDG PET

Popular Abstract in Swedish Huvud- hals cancer Studier kring betydelsen av kärltäthet, svar på strålbehandling och tumörmetabolism, undersökt med positron emissions tomografi ( PET) Bakgrund Cancer i huvud-hals området är ovanligt i Sverige och utgör c:a 2,5% av alla nya cancerfall (40 000) per år. Beteckningen är ett samlingsnamn för tumörer med sinsemellan skilda egenskaper, uppkomna från i förTreatment options of head and neck squamous cell carcinoma (HNSCC) usually include combinations of radiotherapy and surgery, and in some cases addition of chemotherapy. In locally advanced cases cure rates are low. Current prognostic factors cannot foresee the outcome for the individual patient. There is consequently a need for reliable prognostic and predictive factors. Through identification of