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Geographies of transition—From topical concerns to theoretical engagement : A commentary on the transitions research agenda

This viewpoint takes stock with the ‘geography of sustainability transitions’ (GOST) as it is presented in the transitions research agenda. GOST has been a relatively recent addition to transition theorizing, addressing the need for greater sensitivity and attention to the scales, spatialities, and context-specific factors that shape transitions. In our view, the agenda represents a rather narrow

The associations of major foods and fibre with risks of ischaemic and haemorrhagic stroke : A prospective study of 418 329 participants in the EPIC cohort across nine European countries

Aim: To investigate the associations between major foods and dietary fibre with subtypes of stroke in a large prospective cohort. Methods and results: We analysed data on 418 329 men and women from nine European countries, with an average of 12.7 years of follow-up. Diet was assessed using validated country-specific questionnaires which asked about habitual intake over the past year, calibrated us

CRK2 and C-terminal phosphorylation of NADPH oxidase RBOHD regulate reactive oxygen species production in arabidopsis

Reactive oxygen species (ROS) are important messengers in eukaryotic organisms, and their production is tightly controlled. Active extracellular ROS production by NADPH oxidases in plants is triggered by receptor-like protein kinase-dependent signaling networks. Here, we show that CYSTEINE-RICH RLK2 (CRK2) kinase activity is required for plant growth and CRK2 exists in a preformed complex with the

EHS and AHS guidelines for treatment of primary ventral hernias in rare locations or special circumstances

BACKGROUND: Rare locations of hernias, as well as primary ventral hernias under certain circumstances (cirrhosis, dialysis, rectus diastasis, subsequent pregnancy), might be technically challenging. The aim was to identify situations where the treatment strategy might deviate from routine management. METHODS: The guideline group consisted of surgeons from the European and Americas Hernia Societies

Effectiveness of the European Natura 2000 network to sustain a specialist wintering waterbird population in the face of climate change

Analysis of coordinated Greater Scaup (Aythya marila) count data from the last 30 years showed a 38.1% decrease in wintering numbers in North-West Europe, from 309,000 during 1988–1991 to c.192,300 individuals during 2015–2018. Annual trends in wintering numbers differed throughout the range. Numbers decreased in the UK, Ireland, and in the Netherlands, while numbers were stable in Denmark. German

Effects of uniaxial pressure on the spin ice Ho2Ti2 O7

The spin ice materials Ho2Ti2O7 and Dy2Ti2O7 are experimental and theoretical exemplars of highly frustrated magnetic materials. However, the effects of applied uniaxial pressure are not well studied, and here we report magnetization measurements of Ho2Ti2O7 under uniaxial pressure applied in the [001], [111], and [110] crystalline directions. The basic features are captured by an extension of the

A combined strategy of feature selection and machine learning to identify predictors of prediabetes.

Objective: To identify predictors of prediabetes using feature selection and machine learning on a nationally representative sample of the US population. Materials and methods: We analyzed n = 6346 men and women enrolled in the National Health and Nutrition Examination Survey 2013-2014. Prediabetes was defined using American Diabetes Association guidelines. The sample was randomly partitioned to Objective: To identify predictors of prediabetes using feature selection and machine learning on a nationally representative sample of the US population. Materials and methods: We analyzed n = 6346 men and women enrolled in the National Health and Nutrition Examination Survey 2013-2014. Prediabetes was defined using American Diabetes Association guidelines. The sample was randomly partitioned to t

Body ownership and embodiment : Vestibular and multisensory mechanisms

Body ownership and embodiment are two fundamental mechanisms of self-consciousness. The present article reviews neurological data about paroxysmal illusions during which body ownership and embodiment are affected differentially: autoscopic phenomena (out-of-body experience, heautoscopy, autoscopic hallucination, feeling-of-a-presence) and the room tilt illusion. We suggest that autoscopic phenomen

Socioeconomic and marital status among liver cirrhosis patients and associations with mortality : a population-based cohort study in Sweden

BACKGROUND: The importance of socioeconomic status for survival in cirrhosis patients is more or less pronounced within different populations, most likely due to cultural and regional differences combined with dissimilarities in healthcare system organisation and accessibility. Our aim was to study the survival of patients with cirrhosis in a population-based Swedish cohort, using available data o

Transparency, consent and trust in the use of customers' data by an online genetic testing company : an Exploratory survey among 23andMe users

23andMe not only sells genetic testing but also uses customer data in its R&D activities and commercial partnerships. This raises questions about transparency and informed consent. Based on a online survey conducted in 2017–18, we examine attitudes of 368 customers of 23andMe toward the company's use of their data. Our findings point at divides in the context of customers' awareness of the two

Rituals of World Politics: On (Visual) Practices Disordering Things

Rituals are customarily muted into predictable routines aimed to stabilise social orders and limit conflict. As a result, their magic lure recedes into the background, and the unexpected and disruptive elements are downplayed. Our collaborative contribution counters this move by foregrounding rituals of world politics as social practices with notable disordering effects. We engage a series of ‘wor

Clinical and epidemiological features of heart-hand syndrome, an updated analysis in China

Background: The purpose of this study was to prospectively recruit patients treated with limb malformation and to explore the prevalence and the clinical and epidemiological features of Heart-Hand Syndrome (HHS) in China. Methods: The consecutive patients treated for congenital upper limb malformation in Beijing Ji Shui Tan Hospital from October 1st, 2016 to October 1st, 2019 were prospectively re

Making the BKW Algorithm Practical for LWE

The Learning with Errors (LWE) problem is one of the main mathematical foundations of post-quantum cryptography. One of the main groups of algorithms for solving LWE is the Blum-Kalai-Wasserman (BKW) algorithm. This paper presents new improvements for BKW-style algorithms for solving LWE instances. We target minimum concrete complexity and we introduce a new reduction step where we partially reduc

Methods and principles of product design for small-scale production based on 3D printing

Technology of 3D printing is opening the possibility for small-scale production in quantities between ten and several hundred pieces. The technology of adding material enables the production of complex and integrated functional concepts in a single-pass process, which consequently potentially reduces the need for assembly operations. Design approaches and manufacturing processing are not mastered

Search for elements 119 and 120

A search for production of the superheavy elements with atomic numbers 119 and 120 was performed in the 50Ti+249Bk and 50Ti+249Cf fusion-evaporation reactions, respectively, at the gas-filled recoil separator TASCA at GSI Darmstadt, Germany. Over four months of irradiation, the 249Bk target partially decayed into 249Cf, which allowed for a simultaneous search for both elements. Neither was detecte

Evolutionary consequences of sex-specific selection in variable environments : four simple models reveal an array of possible evolutionary outcomes

The evolutionary trajectories of species with separate sexes depend on the effects of genetic variation on female and male traits as well as the direction and alignment of selection between the sexes. Classical theory has shown that evolution is equally responsive to selection on females and males, with natural selection increasing the product of the average relative fitness of each sex over time.

Genetically Predicted Levels of DNA Methylation Biomarkers and Breast Cancer Risk : Data From 228 951 Women of European Descent

BACKGROUND: DNA methylation plays a critical role in breast cancer development. Previous studies have identified DNA methylation marks in white blood cells as promising biomarkers for breast cancer. However, these studies were limited by low statistical power and potential biases. Using a new methodology, we investigated DNA methylation marks for their associations with breast cancer risk. METHODS

Long-term population trends and shifts in distribution of Bewick's swans cygnus columbianus bewickii wintering in northwest Europe

Coordinated international censuses of the Northwest European Bewick's Swan Cygnus columbianus bewickii population have been undertaken across the swans' wintering range at c. 5-year intervals since 1984. During the early years of the study, numbers increased steadily to a peak of 29,780 individuals in January 1995, but then declined by 39.4% to 18,057 swans counted in January 2010 before showing a