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Better health outcomes and reduced societal costs – both senior meetings and a preventive home visit result in cost-effective use of resources

Health economic evaluations provide decision makers with information whether the health effects of one intervention come at a reasonable cost in relation to a comparator. The existing evidence indicate that health promotion for community-dwelling older people result in a range of positive health outcomes, but there is a general lack of health economic evaluation. The aim was to evaluate cost-effec

Epigenetic Mapping in Type 2 Diabetes. Glucose-triggered histone modifications in various tissues

Epigenetic modifications triggered by high glucose may predispose to diabetes risk by regulating gene expression activity. A growing body of evidence suggests that histone modification which is an essential component of epigenetic mechanism may play an important role in the development of type 2 diabetes (T2D) and its complications. In this thesis, the overarching aim is to map histone modificatio

Network Analysis of Mindfulness Facets, Affect, Compassion, and Distress

ObjectivesMindfulness, positive affect, and compassion may protect against psychological distress but there is lack of understanding about the ways in which these factors are linked to mental health. Network analysis is a statistical method used to investigate complex associations among constructs in a single network and is particularly suitable for this purpose. The aim of this study was to explo

How Africans Shaped British Colonial Institutions : Evidence from Local Taxation

The institutions that governed most of the rural population in British colonial Africa have been neglected in the literature on colonialism. We use new data on local governments, or "Native Authorities,"to present the first quantitative comparison of African institutions under indirect rule in four colonies in 1948: Nigeria, the Gold Coast, Nyasaland, and Kenya. Tax data show that Native Authoriti

Direct Observation of a Plasmon-Induced Hot Electron Flow in a Multimetallic Nanostructure

Plasmon hot carriers are interesting for photoredox chemical synthesis but their direct utilization is limited by their ultrafast thermalization. Therefore, they are often transferred to suitable accepting materials that expedite their lifetime. Solid-state photocatalysts are technologically more suitable than their molecular counterparts, but their photophysical processes are harder to follow due

Reversible PCET and Ambient Catalytic Oxidative Alcohol Dehydrogenation by {V=O} Perfluoropinacolate Complexes

A new air-stable catalyst for the oxidative dehydrogenation of benzylic alcohols under ambient conditions has been developed. The synthesis and characterization of this compound and the related monomeric and dimeric V(IV)- and V(V)-pinF (pinF = perfluoropinacolate) complexes are reported herein. Monomeric V(IV) complex (Me4N)2[V(O)(pinF)2] (1) and dimeric (μ-O)2-bridged V(V) complex (Me4N)2[V2(O)2

Postural asymmetries, pain, and ability to change position of children with cerebral palsy in sitting and supine : a cross-sectional study

Purpose: To examine any associations between postural asymmetries, postural ability, and pain for children with cerebral palsy in sitting and supine positions. Methods: A cross-sectional study of 2,735 children with cerebral palsy, 0-18 years old, reported into the Swedish CPUP registry. Postural asymmetries, postural ability, the gross motor function classification system levels I–V, sex, age and

Improved soil hydrological modeling with the implementation of salt-induced freezing point depression in CoupModel : Model calibration and validation

Soil freezing/thawing is an important mechanism to control soil water and heat redistribution in mid-to-high latitudes. Salt in the agricultural soil from mid-to-high latitudes can alter characteristics of soil freezing/thawing cycle and then affect soil thermal and hydrological processes in winter and finally cause salinization in spring. To quantify the impacts of soil salinization on soil water

Low-dose in situ prelocation of protein microcrystals by 2D X-ray phase-contrast imaging for serial crystallography

Serial protein crystallography has emerged as a powerful method of data collection on small crystals from challenging targets, such as membrane proteins. Multiple microcrystals need to be located on large and often flat mounts while exposing them to an X-ray dose that is as low as possible. A crystal-prelocation method is demonstrated here using low-dose 2D full-field propagation-based X-ray phase

High-dose naloxone : Effects by late administration on pain and hyperalgesia following a human heat injury model. A randomized, double-blind, placebo-controlled, crossover trial with an enriched enrollment design

Severe chronic postsurgical pain has a prevalence of 4–10% in the surgical population. The underlying nociceptive mechanisms have not been well characterized. Following the late resolution phase of an inflammatory injury, high-dose μ-opioid-receptor inverse agonists reinstate hypersensitivity to nociceptive stimuli. This unmasking of latent pain sensitization has been a consistent finding in roden

Validation of prostate cancer risk variants rs10993994 and rs7098889 by CRISPR/Cas9 mediated genome editing

GWAS have identified numerous SNPs associated with prostate cancer risk. One such SNP is rs10993994. It is located in the β-microseminoprotein (MSMB) promoter region, mediates MSMB prostate secretion levels, and is linked to mRNA expression changes in both MSMB and the adjacent gene NCOA4. In addition, our previous work showed a second SNP, rs7098889, is in positive linkage disequilibrium with rs1

Risk of colorectal cancer in patients with diabetes mellitus : A Swedish nationwide cohort study

BACKGROUND: Colorectal cancer (CRC) incidence is increasing among young adults below screening age, despite the effectiveness of screening in older populations. Individuals with diabetes mellitus are at increased risk of early-onset CRC. We aimed to determine how many years earlier than the general population patients with diabetes with/without family history of CRC reach the threshold risk at whi

The Health of Older Family Caregivers–A 6-Year Follow-up

It is unclear whether caregiving has an impact on the physical, mental and functional health of older caregivers. This study aimed to describe physical, mental and functional health in relation to family caregiving in old age (60+) over a six-year period. The study comprised 2,294 randomly selected individuals (60–96 years) from the Swedish National Study on Aging and Care, who answered the questi

Review of wildfire indices : Indices applicable for a Swedish context

Wildfire risk indices can be used in order to be better prepared for wildfires. In Sweden, the Canadian Fire Weather Index (FWI) is currently used to predict fire behaviour based on meteorological data such as wind velocity, temperature and rainfall. Additionally, the HBV model, used to calculate moisture content in soil layers, serves to predict the ignition risk in Sweden. There are however many

Regional inhaled deposited dose of indoor combustion-generated aerosols in jordanian urban homes

Indoor combustion processes associated with cooking, heating, and smoking are a major source of aerosols in Jordanian dwellings. To evaluate human exposure to combustion-generated aerosols in Jordanian indoor environments, regional inhaled deposited dose rates of indoor aerosols (10 nm to 25 µm) were determined for different scenarios for adult occupants. The inhaled deposited dose rate provides a

Evaluation of competence in ultrasound-guided procedures—a generic assessment tool developed through the Delphi method

Objectives: To develop a generic and objective tool for assessing competence in percutaneous ultrasound-guided procedures. Methods: Interventional ultrasound experts from the Nordic countries were invited to participate in a three-round Delphi process. A steering committee was formed to manage the process. In round 1, the experts were asked to suggest all aspects to consider when assessing compete

Review of flooding indices : Indices applicable for a Swedish context

Flood risk indices and methods (such as flood risk maps) can be used for long-term pro-active activities like urban planning to reduce flooding risk but also for short-term action such as issuing early warnings when hydro-meteorological conditions are expected to develop in a way that could lead to flooding. There are many different flood risk indices and methods used in the world and this study a