Accident prediction models are often used to predict the number of accidents on segments and at intersections in the road network. Most often the models are developed for a total number of crashes for the facility, or crashes by severity. However, the frequency and severity of crashes of different types can be expected to vary with regards to the underlying phenomena that cause them to occur. To b

Purpose We investigated whether active video gaming (AVG) could bring about regular, enjoyable, physical exercise in children treated for brain tumours, what level of physical activity could be reached and if the children's physical functioning improved. Methods Thirteen children, aged 7-17 years, were randomised to either AVG or waiting-list. After 10-12 weeks they crossed-over. Weekly Internet c

More knowledge concerning the association between physical activity and objectively measured attributes of the built environment is needed. Previous studies on the association between objectively measured neighborhood walkability, physical activity, and walking have been conducted in the U.S. or Australia and research findings are available from only one country in Europe - Belgium. The first aim

Purpose: In order to evaluate long-term effects on neurodevelopment in children born to women with epilepsy during pregnancy we studied the children's school grades at age 16. Methods: We used the Patient Register, the Medical Birth Register, and a local study at South Hospital, Stockholm, to identify women with epilepsy in Sweden who had given birth between 1973 and 1986. The Swedish School Mark

BRCA1 and BRCA2 screening in women at high-risk of breast cancer results in the identification of both unambiguously defined deleterious mutations and sequence variants of unknown clinical significance (VUS). We examined a population-based sample of young women with contralateral breast cancer (CBC, n=705) or unilateral breast cancer (UBC, n=1398). We identified 470 unique sequence variants, of wh

BACKGROUND: Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases worldwide. In high-income countries, low socioeconomic status seems to be related to a high incidence of T2DM, but very little is known about the intermediate factors of this relationship. METHOD: We performed a case-cohort study in eight Western European countries nested in the EPIC study (n = 340 234, 3.99

Myxoinflammatory fibroblastic sarcoma (MIFS) is a low-grade malignant neoplasm for which limited genetic information, including a t(1;10)(p22;q24) and amplification of chromosome 3 material, is available. To further characterize these aberrations, we have investigated eight soft tissue sarcomas diagnosed as MIFS, haemosiderotic fibrolipomatous tumour (HFT), myxoid spindle cell/pleomorphic sarcoma

INTRODUCTION: Numerous associations between chronic kidney disease (CKD) and atrial fibrillation (AF) have been reported and patients with CKD on anticoagulation therapy have an increased risk of bleeding. Currently, new anticoagulant agents are emerging in clinical practice, some of which are excreted by the kidneys. The proportion of AF patients on anticoagulant treatment with reduced renal func

To analyse oncological and functional outcomes 12 months after treatment of very low risk prostate cancer with radical prostatectomy in men who could have been candidates for active surveillance.

Many gene defects are relatively easy to identify experimentally, but obtaining information about the effects of sequence variations and elucidation of the detailed molecular mechanisms of genetic diseases will be among the next major efforts in mutation research. Amino acid substitutions may have diverse effects on protein structure and function; thus, a detailed analysis of the mutations is esse

In retailing literature, shopping as a leisure-time enjoyment has typically been examined by the use of economic or psychological approaches. Consumers engaged in this activity have commonly been portrayed as one homogenous segment. Drawing upon a sociocultural approach, this study seeks to improve our understanding of leisure shopping as subjectively experienced. The article illustrates that leis

The long-term effects of the active accelerator pedal were evaluated in the city of Lund in 2000 and 2001. The system, installed in 284 vehicles, produced a counterforce in the accelerator pedal at the speed limit. It could, however be overridden by pressing the accelerator pedal harder. The results showed that test drivers’ compliance with the speed limits improved considerably. Reduction in aver

“The laser-induced incandescence (LII) signal is proportional to soot volume fraction” is an often used statement in scientific papers, and it has – within experimental uncertainties – been validated in comparisons with other diagnostic techniques in several investigations. In 1984 it was shown theoretically in a paper by Melton that there is a deviation from this statement in that the presence of

The ERP effects of left-edge, sentence-medial boundary tones in East Swedish were examined using synthesized and non-synthesized F0. The perception of the boundary tone gave rise to an N100 effect, reflecting automated processing of the acoustic features of the stimuli, a broadly distributed P200 effect, similar to what has earlier been seen for sentence-initial pitch accents, and an expectancy ne

The transient receptor potential ankyrin subtype 1 protein (TRPA1) is a nonselective cation channel permeable to Ca(2+), Na(+), and K(+). TRPA1 is a promiscuous chemical nocisensor that is also involved in noxious cold and mechanical sensation. It is present in a subpopulation of Aδ- and C-fiber nociceptive sensory neurons as well as in other sensory cells including epithelial cells. In primary se