Search results

Filter

Filetype

Your search for "*" yielded 530825 hits

Dual-focus coherent anti-Stokes Raman scattering microscopy using a compact two-beam fiber laser source

We have developed a dual-focus coherent anti-Stokes Raman scattering (CARS) microscope based on a dual output, compact fiber laser source. The underlying concepts of time-multiplexed, two-beam scanning and demultiplexed detection that we already employed for second-harmonic generation are here naturally extended for CARS microscopy. The layout of a robust, all-fiber laser source was reconfigured t

Electronic structure transformation in small bare Au clusters as seen by x-ray photoelectron spectroscopy

Free bare gold clusters in the size range from few tens to few hundred atoms (≤1 nm dimensions) have been produced in a beam, and the size-dependent development of their full valence band including the 5d and 6s parts has been mapped 'on the fly' by synchrotron-based photoelectron spectroscopy. The Au 4f core level has been also probed, and the cluster-specific Au 4f ionization energies have been

Introduction to macroscopic power scaling principles for high-order harmonic generation

This tutorial presents an introduction to power scaling concepts for high-order harmonic generation (HHG) and attosecond pulse production. We present an overview of state-of-the-art HHG-based extreme ultraviolet (XUV) sources, followed by a brief introduction to basic principles underlying HHG and a detailed discussion of macroscopic effects and scaling principles. Particular emphasis is put on a

SMIM1 variants rs1175550 and rs143702418 independently modulate Vel blood group antigen expression

The Vel blood group antigen is expressed on the red blood cells of most individuals. Recently, we described that homozygosity for inactivating mutations in SMIM1 defines the rare Vel-negative phenotype. Still, Vel-positive individuals show great variability in Vel antigen expression, creating a risk for Vel blood typing errors and transfusion reactions. We fine-mapped the regulatory region located

White to beige conversion in PDE3B KO adipose tissue through activation of AMPK signaling and mitochondrial function

Understanding mechanisms by which a population of beige adipocytes is increased in white adipose tissue (WAT) reflects a potential strategy in the fight against obesity and diabetes. Cyclic adenosine monophosphate (cAMP) is very important in the development of the beige phenotype and activation of its thermogenic program. To study effects of cyclic nucleotides on energy homeostatic mechanisms, mic

Retrofitting Electrically Heated Single-Family Houses to Net-Zero Energy

Only in Sweden, single-family houses account for approximately 30% of energy use in all buildings and a large part uses only electricity for heating. The potential for improvements on energy efficiency in these houses is large. This study theoretically investigates retrofitting of electrically heated Swedish single-family houses by using an air-source heat pump for both space heating and domestic

Predistortion- and development-platform for multi-input RF power amplifiers

We present a real-time digital predistortion (DPD) and RF power amplifier (PA) development platform with separate synchronous and coherent RF channels to evaluate multi-input RF PAs with realistic modulated test signals. The platform is based on a Xilinx FPGA and wideband analog frontends to support signal bandwidths up to 312.5 MHz. We describe both the implemented hardware as e.g. DPD core and d

Spotted phenotypes in horses lost attractiveness in the Middle Ages

Horses have been valued for their diversity of coat colour since prehistoric times; this is especially the case since their domestication in the Caspian steppe in ∼3,500 BC. Although we can assume that human preferences were not constant, we have only anecdotal information about how domestic horses were influenced by humans. Our results from genotype analyses show a significant increase in spotted

Advances in male reproductive surgery : robotic-assisted vasovasostomy

It is estimated that 3-6% of all vasectomised men request vasectomy reversal for different reasons. Microsurgical vasovasostomy is the gold standard technique of vasectomy reversal. However, the microsurgical technique is time-consuming and challenging to most urological surgeons. Therefore, alternative methods of vasal anastomosis have been studied including robotic-assisted vasovasostomy. This r

Testicular biopsy : clinical practice and interpretation

Testicular biopsy was considered the cornerstone of male infertility diagnosis for many years in men with unexplained infertility and azoospermia. Recent guidelines for male infertility have limited the indications for a diagnostic testicular biopsy to the confirmation of obstructive azoospermia in men with normal size testes and normal reproductive hormones. Nowadays, testicular biopsies are main

Cooperation facilitates the colonization of harsh environments

Animals living in harsh environments, where temperatures are hot and rainfall is unpredictable, are more likely to breed in cooperative groups. As a result, harsh environmental conditions have been accepted as a key factor explaining the evolution of cooperation. However, this is based on evidence that has not investigated the order of evolutionary events, so the inferred causality could be incorr

Fracture study of ferritic/martensitic steels using Weibull stress analysis at quasi-static and higher loading rates

Effect of loading rate on cleavage failure probability for ferritic/martensitic steels using Weibull stress analysis is studied. Calibration of Weibull slope for two grades of fusion reactor blanket steels namely, Indian Reduced Activation Ferritic/Martensitic Steel referred as In-RAFMS, F 82H and a non fusion grade modified 9Cr-1Mo steel (P91) are performed for the first time. The calibrated valu

Synthesis, Crystal Structures, Magnetic Properties, and Theoretical Investigation of a New Series of NiII-LnIII-WV Heterotrimetallics : Understanding the SMM Behavior of Mixed Polynuclear Complexes

The polynuclear compounds containing anisotropic metal ions often exhibit efficient barriers for blocking of magnetization at fairly arbitrary geometries. However, at variance with mononuclear complexes, which usually become single-molecule magnets (SMM) under the sole requirement of a highly axial crystal field at the metal ion, the factors influencing the SMM behavior in polynuclear complexes, e

Sensory Clusters of Adults With and Without Autism Spectrum Conditions

We identified clusters of atypical sensory functioning adults with ASC by hierarchical cluster analysis. A new scale for commonly self-reported sensory reactivity was used as a measure. In a low frequency group (n = 37), all subscale scores were relatively low, in particular atypical sensory/motor reactivity. In the intermediate group (n = 17) hyperreactivity, sensory interests and sensory/motor i

Odour-based discrimination of similarity at the major histocompatibility complex in birds

Many animals are known to preferentially mate with partners that are dissimilar at the major histocompatibility complex (MHC) in order to maximize the antigen binding repertoire (or disease resistance) in their offspring. Although several mammals, fish or lizards use odour cues to assessMHCsimilarity with potential partners, the ability of birds to assessMHC similarity using olfactory cues has not

Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease

The aggregation of the 42-residue form of the amyloid-β peptide (Aβ42) is a pivotal event in Alzheimer's disease (AD). The use of chemical kinetics has recently enabled highly accurate quantifications of the effects of small molecules on specific microscopic steps in Aβ42 aggregation. Here, we exploit this approach to develop a rational drug discovery strategy against Aβ42 aggregation that uses as

Coal, commerce and communism : Empirical studies on energy history in the Czech Republic

This thesis employs an international comparative perspective to empirically analyse the Czech energy transition between 1830 and 2010. It addresses the utilization of energy in shaping modern economic growth through structural and technological change and the implications of those changes on specialization and foreign trade. New historical data is collected and utilized to investigate the impact o