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The breast cancer susceptibility gene BARD1 (BRCA1-associated RING domain protein, MIM# 601593) acts with BRCA1 in DNA double-strand break (DSB) repair and also in apoptosis initiation. We screened 109 BRCA1/2 negative high-risk breast and/or ovarian cancer patients from North-Eastern Poland for BARD1 germline mutations using a combination of denaturing high-performance liquid chromatography and d
Context: Preterm birth is followed by a decrease in circulatory levels of IGF-I and IGF binding protein-3 (IGFBP-3), proteins with important neurogenic and angiogenic properties. Objective: To evaluate effects of intravenous administration of fresh frozen plasma (FFP) from adult donors on circulatory levels of IGF-I and IGFBP-3 in extremely preterm infants. Design, setting and patients: A prospect
PHENIX has measured the e(+)e(-) pair continuum in root s(NN) = 200 GeV Au+Au and p+p collisions over a wide range of mass and transverse momenta. The e(+)e(-) yield is compared to the expectations from hadronic sources, based on PHENIX measurements. In the intermediate-mass region, between the masses of the phi and the J/psi meson, the yield is consistent with expectations from correlated c (c) o
Quantum graphs having one cycle are considered. It is shown that if the cycle contains at least three vertices. then the potential oil the graph can be uniquely reconstructed from the corresponding Titchmarsh-Weyl function (Dirichlet-to-Neumann map) associated with graph's boundary, provided certain non-resonant conditions are satisfied
The human nasal epithelium is an important physical barrier, and a part of the innate immune defense that protect against pathogens. The epithelial cells recognize microbial components by pattern-recognition receptors (PRRs), and thereby trigger an immune response. Even though TLR3, TLR7, TLR9, RIG-I and MDA-5 are all known to respond to viral stimulation, their potential role in chronic airway in
Bengt Holmberg is widely known and respected as one of the pioneers of the sociological study of the New Testament. His dissertation, Paul and Power, published by CWK Gleerup in 1978 and by Fortress Press in 1980, was among the first studies to use sociological theory to explore and more deeply understand the Pauline letters, and it set the agenda for much future research. Partly on the basis of h
Moving towards an ecologically sound society requires strong support from higher educational institutions. During the past decade, the Journal of Cleaner Production has published more than 150 articles that have highlighted advances in academic efforts on sustainability in higher education, that were focused upon education, research, outreach and greening of campus operations in universities from
Abstract The ozone (O3) decomposition in the pre-heat zone of flames can initiate and accelerate the chain-branching reactions. In the present study, formaldehyde (CH2O) was investigated by both experiment and simulation methods in methane/air laminar premixed flames under atmospheric conditions. The formaldehyde concentration profiles in the flames were measured with CH2O-PLIF. When 4500 ppm of o
Popular Abstract in Swedish Övervikt och fetma ökar i hela världen och fortfarande vet ingen exakt varför vi äter mer än kroppen behöver. En rådande teori är att den västerländska dieten till stor del innehåller ”supervälsmakande” mat med mycket socker och fett som godis, glass, chips och feta såser. Sådan mat ökar risken för överkonsumtion och kan därför leda till övervikt och fetma. Att öka mättWestern diet contains a high proportion of palatable food, rich in refined carbohydrates and fat, that subsequently increases the risk of overconsumption and possibly leads to overweight and obesity. Therefore an approach to strengthen the inherent satiety for fat can be used to prevent overconsumption. Thylakoid membranes isolated from the chloroplast of green leaves have been found to reduce the
This paper presents a novel process for n-butanol production which combines a fermentation consuming carbon dioxide (succinic acid fermentation) with subsequent catalytic reduction steps to add hydrogen to form butanol. Process simulations in Aspen Plus have been the basis for the techno-economic analyses performed. The overall economy for the novel process cannot be justified, as production of su
The only validated method to characterize the phenotype and to reach a definitive diagnosis of Malignant Hyperthermia Susceptibility (MHS; OMIM *145600), a pharmacogenetic disease linked to the Ryanodine 1 receptor gene (RYR1; OMIM *180901), is an invasive muscle contraction test requiring a muscle biopsy, according to the European (IVCT) protocol or to the North American (CHCT) protocol. The seri
Objectives To describe changes in uterine and ovarian size and morphology as determined by ultrasonography from 2 years before to 2 years after menopause. Methods Twenty 50-year-old women with fairly regular vaginal bleeding at the start of the study underwent transvaginal ultrasound examination every 3 months until 12 months postmenopause, then every 6 months until 24 months postmenopause. The re
The 1920s saw a significant exchange between eugenicists in Swedenand the young Soviet state. Sweden did not take part in World War I, and duringthe years following immediately upon the Versailles peace treaty, Swedishscholars came to serve as an intermediary link between, on the one hand, SovietRussia and Weimar Germany, and, on the other hand, Western powers. Swedisheugenicists organized confere
Popular Abstract in Swedish Personer som drabbas av hjärtstopp riskerar grava hjärnskador p.g.a. brist på blodflöde till hjärnan. Patienterna blir ofta långvarigt medvetslösa och vårdas på intensiv¬vårdsavdelning i respirator. Risken för hjärnskada kan minskas med kyl¬behandling. Under kylbehandlingen, cirka 1.5 dygn, får patienten sederande och ev. muskelavslappnande medicin för att minska ”huttrAbstract Therapeutic hypothermia (TH) is the only treatment available to reduce neurological sequels for unconscious patients following cardiac arrest (CA). TH requires sedation and muscular relaxation, obscuring the clinical neurological examination for estimation of prognosis, and clinical decision making. Continuous amplitude-integrated EEG (aEEG) has been used to predict outcome in neonates
Background: Osteoporosis is a common bone disease, which does not give symptoms until the ultimate outcome, the fragility fracture occurs. Regulation of bone mass is controlled by genetic, environmental and nutritional influences. Peak bone mass, defined as the maximum bone mass accrued, is usually reached by the third decade of life and is an important determinant of future osteoporotic fracture.
